Investigation of key circuit constituents affecting drug sequestration during extracorporeal membrane oxygenation treatment

Jiheum Park, DongAh Shin, Saram Lee, Young Jae Cho, Sanghoon Jheon, Jung Chan Lee, Hee Chan Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We quantified the influence of the elements of the extracorporeal oxygenation (ECMO) circuit on drug sequestration by focusing on the interactions between materials and drugs, Tubing of three different brands (Tygon/Maquet/Terumo) and oxygenators of two different brands (Maquet/Terumo) were used, Drugs included dexmedetomidine, meropenem, and heparin, which were dissolved in deionized water, Tubing was cut into approximately 7 cm sections and allowed drug solutions enclosed inside by clamping both ends, The oxygenator housing, gas membrane, and heat exchanger were dissected into approximately 1 g pieces and submerged into drug solutions, The experimental samples were then immersed in a water bath at 37°C for 1, 6, 12, and 24 h, After 24 h, the dexmedetomidine concentration was significantly reduced in all three types of tubing (<30.1%), the oxygenator heat exchanger from Maquet Inc, (41.8%), and the gas exchanger from Terumo Inc, (8.6%), while no significant losses were found for meropenem and heparin compared with the control group, The heparin concentration within the Maquet gas exchanger, on the contrary, increased significantly compared with the control group at 1 and 12 h (p < 0.05), Our in vitro study reveals that material selection is a vital part of ECMO development,

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalASAIO Journal
Volume63
Issue number3
DOIs
Publication statusPublished - 2017 Jun 1

Fingerprint

Oxygenators
Extracorporeal Membrane Oxygenation
Oxygenation
Tubing
meropenem
Membranes
Heat exchangers
Networks (circuits)
Dexmedetomidine
Heparin
Gases
Pharmaceutical Preparations
Deionized water
Hot Temperature
Therapeutics
Control Groups
Water
Baths
Constriction

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Park, Jiheum ; Shin, DongAh ; Lee, Saram ; Cho, Young Jae ; Jheon, Sanghoon ; Lee, Jung Chan ; Kim, Hee Chan. / Investigation of key circuit constituents affecting drug sequestration during extracorporeal membrane oxygenation treatment. In: ASAIO Journal. 2017 ; Vol. 63, No. 3. pp. 293-298.
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abstract = "We quantified the influence of the elements of the extracorporeal oxygenation (ECMO) circuit on drug sequestration by focusing on the interactions between materials and drugs, Tubing of three different brands (Tygon/Maquet/Terumo) and oxygenators of two different brands (Maquet/Terumo) were used, Drugs included dexmedetomidine, meropenem, and heparin, which were dissolved in deionized water, Tubing was cut into approximately 7 cm sections and allowed drug solutions enclosed inside by clamping both ends, The oxygenator housing, gas membrane, and heat exchanger were dissected into approximately 1 g pieces and submerged into drug solutions, The experimental samples were then immersed in a water bath at 37°C for 1, 6, 12, and 24 h, After 24 h, the dexmedetomidine concentration was significantly reduced in all three types of tubing (<30.1{\%}), the oxygenator heat exchanger from Maquet Inc, (41.8{\%}), and the gas exchanger from Terumo Inc, (8.6{\%}), while no significant losses were found for meropenem and heparin compared with the control group, The heparin concentration within the Maquet gas exchanger, on the contrary, increased significantly compared with the control group at 1 and 12 h (p < 0.05), Our in vitro study reveals that material selection is a vital part of ECMO development,",
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Investigation of key circuit constituents affecting drug sequestration during extracorporeal membrane oxygenation treatment. / Park, Jiheum; Shin, DongAh; Lee, Saram; Cho, Young Jae; Jheon, Sanghoon; Lee, Jung Chan; Kim, Hee Chan.

In: ASAIO Journal, Vol. 63, No. 3, 01.06.2017, p. 293-298.

Research output: Contribution to journalArticle

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