Investigation of memory-enhancing botanical mixture and their isolated compounds for inhibition of amyloid-β and tau aggregation

Seungyeop Baek, Sohui Park, Jisu Shin, Jun Seok Lee, Hye Yun Kim, Gyoonhee Han, Young Soo Kim

Research output: Contribution to journalArticle

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the abnormal assembly of amyloid-β (Aβ) and tau aggregates in the brain. When Aβ and tau proteins misfold, progressive brain cell death, synaptic loss, atrophy, and cognitive decline are observed. Here, we report that the memory-enhancing botanical natural product mixture, HX106N, efficiently inhibits formation of Aβ oligomers and fibrils and aggregation of tau. HX106N is a botanical mixture extract of Dimocarpus longan, Liriope platyphylla, Salvia miltiorrhiza and Gastrodia elata. In previous clinical studies, HX106N showed increased working memory performances of individuals of subjective memory complaints. However, the drug mechanism and responsible ingredients of HX106N has been unclear yet. In this study, we expanded the investigation of the drug mode of action to the single chemical level by identifying four active components of HX106N, among 14 isolated molecules, with significant inhibitory function against Aβ aggregation. We found that salvianolic acids A, B, E and rosmarinic acid, isolated from the botanical mixture, have potency to inhibit the protein misfolding.

Original languageEnglish
Article number22
JournalApplied Biological Chemistry
Volume63
Issue number1
DOIs
Publication statusPublished - 2020 Dec 1

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry

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