Investigation of suitable starting doses of narrowband UVB in Asian vitiligo patients: a pilot study

H. Lee, H. Chu, S. H. Oh

Research output: Contribution to journalArticle

Abstract

Background: Phototherapy is the preferred treatment modality for active and generalized vitiligo. One of the widely accepted consensus on starting dose of phototherapy is using a uniform dose of 280 mJ/cm2 regardless of patients' Fitzpatrick skin phototype (SPT). However, in many clinical experiences with Asian vitiligo patients, the protocol seems suboptimal. Objective: To gather more evidence on establishing a higher starting dosage for Asian vitiligo patients undergoing phototherapy. Methods: We enrolled generalized vitiligo patients with lesions sized adequate enough for phototest. Minimal erythema dose (MED) of vitiligo lesion and non-lesion was measured along with melanin index (MI). Results: Relatively, a wide range of MED and MI was observed even among patients with similar SPT. The range of MED for lesional skin was 300–700 mJ/cm2 and the MED for non-lesion was 500–800 mJ/cm2. Correlation was noted between lesional MED and non-lesional MI (Spearman correlation, ρ = 0.664 [P < 0.036]) and mean lesional MED was approximately 65% of mean non-lesional MED. Conclusion: Results from phototest and tolerability of patients to doses higher than 280 mJ/cm2 may indicate that higher starting doses might be appropriate for Asian vitiligo patients.

Original languageEnglish
Pages (from-to)894-897
Number of pages4
JournalJournal of the European Academy of Dermatology and Venereology
Volume31
Issue number5
DOIs
Publication statusPublished - 2017 May 1

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Vitiligo
Erythema
Phototherapy
Melanins
Skin

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Cite this

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abstract = "Background: Phototherapy is the preferred treatment modality for active and generalized vitiligo. One of the widely accepted consensus on starting dose of phototherapy is using a uniform dose of 280 mJ/cm2 regardless of patients' Fitzpatrick skin phototype (SPT). However, in many clinical experiences with Asian vitiligo patients, the protocol seems suboptimal. Objective: To gather more evidence on establishing a higher starting dosage for Asian vitiligo patients undergoing phototherapy. Methods: We enrolled generalized vitiligo patients with lesions sized adequate enough for phototest. Minimal erythema dose (MED) of vitiligo lesion and non-lesion was measured along with melanin index (MI). Results: Relatively, a wide range of MED and MI was observed even among patients with similar SPT. The range of MED for lesional skin was 300–700 mJ/cm2 and the MED for non-lesion was 500–800 mJ/cm2. Correlation was noted between lesional MED and non-lesional MI (Spearman correlation, ρ = 0.664 [P < 0.036]) and mean lesional MED was approximately 65{\%} of mean non-lesional MED. Conclusion: Results from phototest and tolerability of patients to doses higher than 280 mJ/cm2 may indicate that higher starting doses might be appropriate for Asian vitiligo patients.",
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Investigation of suitable starting doses of narrowband UVB in Asian vitiligo patients : a pilot study. / Lee, H.; Chu, H.; Oh, S. H.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 31, No. 5, 01.05.2017, p. 894-897.

Research output: Contribution to journalArticle

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