Investigation of Systolic Blood Pressure, Diastolic Blood Pressure, and Pulse Pressure in Living Kidney Donors After Donor Nephrectomy

Jee Soo Park, Min Gee Yoon, Joon Chae Na, Hyung Ho Lee, Young Eun Yoon, Kyu Ha Huh, Yu Seun Kim, Woong Kyu Han

Research output: Contribution to journalArticle

Abstract

Kidney transplants from living donors have increased, but few studies have examined the long-term risks of live donor nephrectomy. This is the first study to report the blood pressure (BP) changes associated with cardiovascular disease and linked to chronic kidney disease (CKD) 1 year after live donor nephrectomy. This study examined a prospective cohort of patients who underwent donor nephrectomy between March 1, 2006, and December 31, 2016, at the Severance Hospital, Seoul, South Korea. CKD was defined as a glomerular filtration rate (GFR) of < 60 mL/min/1.73m2. Patients with a history of hypertension or CKD or an estimated GFR < 60 mL/min/1.73m2 were excluded; those examined after 1 year post-nephrectomy were included in the study population. Among 420 patients who underwent donor nephrectomy, 137 (32.6%) developed a first-time onset of a GFR < 60 mL/min/1.73m2 by the first year after surgery. After propensity score–matching the age, systolic BP (P <.001) and pulse pressure (P =.006) were significantly associated with the groups with newly developed CKD. Systolic BP and pulse pressure decreased significantly at 1 year after donor nephrectomy. These differences decreased after donor nephrectomy, possibly lowering the risk of cardiovascular disease.

Original languageEnglish
Pages (from-to)2533-2538
Number of pages6
JournalTransplantation Proceedings
Volume51
Issue number8
DOIs
Publication statusPublished - 2019 Oct

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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