Investigation of the β-catenin gene in a case of dentinogenic ghost cell tumor

Soo A. Kim; Sang Gun Ahn; Su Gwan Kim; Joo Cheol Park; Sang Ho Lee; Jin Kim; Jung Hoon Yoon

doi:10.1016/j.tripleo.2005.10.037

Investigation of the β-catenin gene in a case of dentinogenic ghost cell tumor

Soo A. Kim, Sang Gun Ahn, Su Gwan Kim, Joo Cheol Park, Sang Ho Lee, Jin Kim, Jung Hoon Yoon

Department of Oral Pathology

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT → TCT) of β-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell-containing odontogenic lesions.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume	103
Issue number	1
DOIs	https://doi.org/10.1016/j.tripleo.2005.10.037
Publication status	Published - 2007 Jan

Bibliographical note

Funding Information:
This study was supported by research funds from Chosun University, Korea (2003).

All Science Journal Classification (ASJC) codes

Surgery
Oral Surgery
Otorhinolaryngology
Dentistry(all)

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title = "Investigation of the β-catenin gene in a case of dentinogenic ghost cell tumor",

abstract = "Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT → TCT) of β-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell-containing odontogenic lesions.",

author = "Kim, {Soo A.} and Ahn, {Sang Gun} and Kim, {Su Gwan} and Park, {Joo Cheol} and Lee, {Sang Ho} and Jin Kim and Yoon, {Jung Hoon}",

note = "Funding Information: This study was supported by research funds from Chosun University, Korea (2003). ",

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doi = "10.1016/j.tripleo.2005.10.037",

language = "English",

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T1 - Investigation of the β-catenin gene in a case of dentinogenic ghost cell tumor

AU - Kim, Soo A.

AU - Ahn, Sang Gun

AU - Kim, Su Gwan

AU - Park, Joo Cheol

AU - Lee, Sang Ho

AU - Kim, Jin

AU - Yoon, Jung Hoon

N1 - Funding Information: This study was supported by research funds from Chosun University, Korea (2003).

PY - 2007/1

Y1 - 2007/1

N2 - Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT → TCT) of β-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell-containing odontogenic lesions.

AB - Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT → TCT) of β-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell-containing odontogenic lesions.

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IS - 1

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Investigation of the β-catenin gene in a case of dentinogenic ghost cell tumor

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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