Abstract
Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT → TCT) of β-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell-containing odontogenic lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 97-101 |
| Number of pages | 5 |
| Journal | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics |
| Volume | 103 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2007 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oral Surgery
- Otorhinolaryngology
- Dentistry(all)
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Investigation of the β-catenin gene in a case of dentinogenic ghost cell tumor. / Kim, Soo A.; Ahn, Sang Gun; Kim, Su Gwan; Park, Joo Cheol; Lee, Sang Ho; Kim, Jin; Yoon, Jung Hoon.
In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 103, No. 1, 01.01.2007, p. 97-101.Research output: Contribution to journal › Article
TY - JOUR
T1 - Investigation of the β-catenin gene in a case of dentinogenic ghost cell tumor
AU - Kim, Soo A.
AU - Ahn, Sang Gun
AU - Kim, Su Gwan
AU - Park, Joo Cheol
AU - Lee, Sang Ho
AU - Kim, Jin
AU - Yoon, Jung Hoon
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT → TCT) of β-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell-containing odontogenic lesions.
AB - Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT → TCT) of β-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell-containing odontogenic lesions.
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UR - http://www.scopus.com/inward/citedby.url?scp=33845419002&partnerID=8YFLogxK
U2 - 10.1016/j.tripleo.2005.10.037
DO - 10.1016/j.tripleo.2005.10.037
M3 - Article
C2 - 17178501
AN - SCOPUS:33845419002
VL - 103
SP - 97
EP - 101
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
SN - 2212-4403
IS - 1
ER -