Ionic liquid of a gold nanocluster: A versatile matrix for electrochemical biosensors

Kyuju Kwak, S. Senthil Kumar, Kyunglim Pyo, Dongil Lee

Research output: Contribution to journalArticlepeer-review

117 Citations (Scopus)


Ionic liquids are room-temperature molten salts that are increasingly used in electrochemical devices, such as batteries, fuel cells, and sensors, where their intrinsic ionic conductivity is exploited. Here we demonstrate that combining anionic, redox-active Au25 clusters with imidazolium cations leads to a stable ionic liquid possessing both ionic and electronic conductivity. The Au25 ionic liquid was found to act as a versatile matrix for amperometric enzyme biosensors toward the detection of glucose. Enzyme electrodes prepared by incorporating glucose oxidase in the Au 25 ionic liquid show high electrocatalytic activity and substrate affinity. Au25 clusters in the electrode were found to act as effective redox mediators as well as electronic conductors determining the detection sensitivity. With the unique electrochemical properties and almost unlimited structural tunability, the ionic liquids of quantum-sized gold clusters may serve as versatile matrices for a variety of electrochemical biosensors.

Original languageEnglish
Pages (from-to)671-679
Number of pages9
JournalACS Nano
Issue number1
Publication statusPublished - 2014 Jan 28

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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