Is kidney graft biopsy indicated in recipients with newly developed, microscopic hematuria?

Yu Seun Kim, Hyeon Joo Jeong, Myoung Soo Kim, Soon I.I. Kim, Dae Suk Han

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We actively performed renal allograft biopsies on 87 living donor renal transplant recipients presenting with stable serum creatinine but showing newly developed recurrent microscopic hematuria with a small amount of proteinuria during the maintenance phase of immunosuppression and found definite pathological lesions in 56 cases (64%). Chronic rejection of a mild grade (n = 27) and various kinds of glomerulonephritis (n = 27) were the major pathological diagnoses, and from 14 cases singular or complicated cyclosporine (CsA) toxicity was found. Twenty-four out of the 27 glomerulonephritis cases were IgA nephropathy, which is the most common glomerulonephritis in Korea. Through this study, the authors found chronic rejection or glomerulonephritis even in grafts which are generally considered to be normal. CsA nephrotoxicity, which was not expected clinically, could be found. In summary, renal allograft biopsy on patients, even with stable graft function when they start to show microscopic hematuria with or without a small amount of proteinuria, should be perfomed to document the early intragraft events if there are no medical contraindications.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalClinical Transplantation
Volume12
Issue number2
Publication statusPublished - 1998 Dec 1

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Hematuria
Glomerulonephritis
Transplants
Kidney
Biopsy
Proteinuria
Allografts
Living Donors
Korea
Immunosuppression
Immunoglobulin A
Cyclosporine
Creatinine
Maintenance
Serum

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Kim, Yu Seun ; Jeong, Hyeon Joo ; Kim, Myoung Soo ; Kim, Soon I.I. ; Han, Dae Suk. / Is kidney graft biopsy indicated in recipients with newly developed, microscopic hematuria?. In: Clinical Transplantation. 1998 ; Vol. 12, No. 2. pp. 104-108.
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Is kidney graft biopsy indicated in recipients with newly developed, microscopic hematuria? / Kim, Yu Seun; Jeong, Hyeon Joo; Kim, Myoung Soo; Kim, Soon I.I.; Han, Dae Suk.

In: Clinical Transplantation, Vol. 12, No. 2, 01.12.1998, p. 104-108.

Research output: Contribution to journalArticle

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