Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? results from the multinational coronary ct angiography evaluation for clinical outcome

An international multicenter registry (confirm)

Amir Ahmadi, Jonathon Leipsic, Gudrun Feuchtner, Heidi Gransar, Dan Kalra, Ran Heo, Stephan Achenbach, Daniele Andreini, Mouaz Al-Mallah, Daniel S. Berman, Matthew Budoff, Filippo Cademartiri, Tracy Q. Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin Chow, Ricardo C. Cury, Augustin Delago, Millie J. Gomez, Martin Hadamitzky & 12 others Joerg Hausleiter, Niree Hindoyan, Philipp A. Kaufmann, Yong Jin Kim, Fay Lin, Erica Maffei, Gianluca Pontone, Gilbert L. Raff, Leslee J. Shaw, Todd C. Villines, Allison Dunning, James K. Min

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n=690) were matched 1:1:1 to those with 1 component (n=690) and 2 components (n=690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p<0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p>0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p=0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p=0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome.

Original languageEnglish
Article numbere0118998
JournalPloS one
Volume10
Issue number3
DOIs
Publication statusPublished - 2015 Mar 3

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Angiography
metabolic syndrome
Coronary Angiography
Registries
Coronary Artery Disease
Adenosine Triphosphate
prognosis
coronary artery disease
Detectors
Composite materials
myocardial infarction
Acute Coronary Syndrome
cohort studies
cardiovascular diseases
detectors
Cohort Studies
Cardiovascular Diseases
Cross-Sectional Studies
Smoking
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Ahmadi, Amir ; Leipsic, Jonathon ; Feuchtner, Gudrun ; Gransar, Heidi ; Kalra, Dan ; Heo, Ran ; Achenbach, Stephan ; Andreini, Daniele ; Al-Mallah, Mouaz ; Berman, Daniel S. ; Budoff, Matthew ; Cademartiri, Filippo ; Callister, Tracy Q. ; Chang, Hyuk-Jae ; Chinnaiyan, Kavitha ; Chow, Benjamin ; Cury, Ricardo C. ; Delago, Augustin ; Gomez, Millie J. ; Hadamitzky, Martin ; Hausleiter, Joerg ; Hindoyan, Niree ; Kaufmann, Philipp A. ; Kim, Yong Jin ; Lin, Fay ; Maffei, Erica ; Pontone, Gianluca ; Raff, Gilbert L. ; Shaw, Leslee J. ; Villines, Todd C. ; Dunning, Allison ; Min, James K. / Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? results from the multinational coronary ct angiography evaluation for clinical outcome : An international multicenter registry (confirm). In: PloS one. 2015 ; Vol. 10, No. 3.
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title = "Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? results from the multinational coronary ct angiography evaluation for clinical outcome: An international multicenter registry (confirm)",
abstract = "Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n=690) were matched 1:1:1 to those with 1 component (n=690) and 2 components (n=690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4{\%} vs 13.8{\%}, 2.6{\%} vs 4.5{\%}, and 1.0{\%} vs 2.3{\%}, respectively; p<0.05), while those with 2 components did not (10.5{\%} vs 13.8{\%}, 2.8{\%} vs 4.5{\%} and 1.3{\%} vs 2.3{\%}, respectively; p>0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4{\%} vs 1.6{\%}; p=0.002), while no difference observed compared to individuals with 2 components (4.4{\%} vs 3.2{\%} p=0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome.",
author = "Amir Ahmadi and Jonathon Leipsic and Gudrun Feuchtner and Heidi Gransar and Dan Kalra and Ran Heo and Stephan Achenbach and Daniele Andreini and Mouaz Al-Mallah and Berman, {Daniel S.} and Matthew Budoff and Filippo Cademartiri and Callister, {Tracy Q.} and Hyuk-Jae Chang and Kavitha Chinnaiyan and Benjamin Chow and Cury, {Ricardo C.} and Augustin Delago and Gomez, {Millie J.} and Martin Hadamitzky and Joerg Hausleiter and Niree Hindoyan and Kaufmann, {Philipp A.} and Kim, {Yong Jin} and Fay Lin and Erica Maffei and Gianluca Pontone and Raff, {Gilbert L.} and Shaw, {Leslee J.} and Villines, {Todd C.} and Allison Dunning and Min, {James K.}",
year = "2015",
month = "3",
day = "3",
doi = "10.1371/journal.pone.0118998",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

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Ahmadi, A, Leipsic, J, Feuchtner, G, Gransar, H, Kalra, D, Heo, R, Achenbach, S, Andreini, D, Al-Mallah, M, Berman, DS, Budoff, M, Cademartiri, F, Callister, TQ, Chang, H-J, Chinnaiyan, K, Chow, B, Cury, RC, Delago, A, Gomez, MJ, Hadamitzky, M, Hausleiter, J, Hindoyan, N, Kaufmann, PA, Kim, YJ, Lin, F, Maffei, E, Pontone, G, Raff, GL, Shaw, LJ, Villines, TC, Dunning, A & Min, JK 2015, 'Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? results from the multinational coronary ct angiography evaluation for clinical outcome: An international multicenter registry (confirm)', PloS one, vol. 10, no. 3, e0118998. https://doi.org/10.1371/journal.pone.0118998

Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? results from the multinational coronary ct angiography evaluation for clinical outcome : An international multicenter registry (confirm). / Ahmadi, Amir; Leipsic, Jonathon; Feuchtner, Gudrun; Gransar, Heidi; Kalra, Dan; Heo, Ran; Achenbach, Stephan; Andreini, Daniele; Al-Mallah, Mouaz; Berman, Daniel S.; Budoff, Matthew; Cademartiri, Filippo; Callister, Tracy Q.; Chang, Hyuk-Jae; Chinnaiyan, Kavitha; Chow, Benjamin; Cury, Ricardo C.; Delago, Augustin; Gomez, Millie J.; Hadamitzky, Martin; Hausleiter, Joerg; Hindoyan, Niree; Kaufmann, Philipp A.; Kim, Yong Jin; Lin, Fay; Maffei, Erica; Pontone, Gianluca; Raff, Gilbert L.; Shaw, Leslee J.; Villines, Todd C.; Dunning, Allison; Min, James K.

In: PloS one, Vol. 10, No. 3, e0118998, 03.03.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? results from the multinational coronary ct angiography evaluation for clinical outcome

T2 - An international multicenter registry (confirm)

AU - Ahmadi, Amir

AU - Leipsic, Jonathon

AU - Feuchtner, Gudrun

AU - Gransar, Heidi

AU - Kalra, Dan

AU - Heo, Ran

AU - Achenbach, Stephan

AU - Andreini, Daniele

AU - Al-Mallah, Mouaz

AU - Berman, Daniel S.

AU - Budoff, Matthew

AU - Cademartiri, Filippo

AU - Callister, Tracy Q.

AU - Chang, Hyuk-Jae

AU - Chinnaiyan, Kavitha

AU - Chow, Benjamin

AU - Cury, Ricardo C.

AU - Delago, Augustin

AU - Gomez, Millie J.

AU - Hadamitzky, Martin

AU - Hausleiter, Joerg

AU - Hindoyan, Niree

AU - Kaufmann, Philipp A.

AU - Kim, Yong Jin

AU - Lin, Fay

AU - Maffei, Erica

AU - Pontone, Gianluca

AU - Raff, Gilbert L.

AU - Shaw, Leslee J.

AU - Villines, Todd C.

AU - Dunning, Allison

AU - Min, James K.

PY - 2015/3/3

Y1 - 2015/3/3

N2 - Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n=690) were matched 1:1:1 to those with 1 component (n=690) and 2 components (n=690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p<0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p>0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p=0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p=0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome.

AB - Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n=690) were matched 1:1:1 to those with 1 component (n=690) and 2 components (n=690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p<0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p>0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p=0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p=0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome.

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DO - 10.1371/journal.pone.0118998

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JO - PLoS One

JF - PLoS One

SN - 1932-6203

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