Is Pre-Operative Axillary Staging with Ultrasound and Ultrasound-Guided Fine-Needle Aspiration Reliable in Invasive Lobular Carcinoma of the Breast?

Soo Yeon Kim, Eun Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Min Jung Kim

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Axillary ultrasound (US) with US-guided fine-needle aspiration (US-FNA) for suspicious lymph nodes is important for pre-operative staging and planning of surgical management. Invasive lobular carcinoma (ILC) metastases were previously thought to be difficult to detect, but with a limited amount of evidence. This study investigated the ability of US and US-FNA to detect ILC metastases by assessing 142 patients with ILC. The sensitivity of US in detection of metastasis was 52.3%, and US was able to exclude 96% of N2 and N3 axillary metastases. The false-negative rate of US-FNA in detection of metastasis for suspicious lymph nodes on US was 34.8%, and lymph nodes with longer maximal dimensions were associated with false-negative US-FNA results. Multiplicity of breast lesions and maximal cortical thickness ≥3.1 mm of lymph nodes were independently associated with metastasis. Although pre-operative US in ILC can reliably exclude advanced axillary nodal disease, US-FNA results should be carefully interpreted.

Original languageEnglish
Pages (from-to)1263-1272
Number of pages10
JournalUltrasound in Medicine and Biology
Volume42
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program of the National Research Foundation of Korea funded by the Ministry of Science, ICT& Future Planning, Republic of Korea (Grant 2013 R1 A1 A3013165 ), and by a faculty research grant of Yonsei University College of Medicine for 2015 ( 6-2015-0050 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the article.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

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