Is small prostate volume a predictor of gleason score upgrading after radical prostatectomy?

Mun Su Chung, Seung Hwan Lee, Dong Hoon Lee, Byungha Chung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: We aimed to analyze the relationship between prostate volume and Gleason score (GS) upgrading [higher GS category in the radical prostatectomy (RP) specimen than in the prostate biopsy] in Korean men. Materials and Methods: We retrospectively analyzed the medical records of 247 men who underwent RP between May 2006 and April 2011 at our institution. Transrectal ultrasound (TRUS) volume was categorized as 25 cm3 or less (n=61), 25 to 40 cm3 (n=121) and greater than 40 cm3 (n=65). GS was examined as a categorical variable of 6 or less, 3+4 and 4+3 or greater. The relationship between TRUS volume and upgrading of GS was analyzed using multivariate logistic regression. Results: Overall, 87 patients (35.2%) were upgraded, 20 (8.1%) were downgraded, and 140 (56.7%) had identical biopsy and pathological Gleason sum groups. Smaller TRUS volume was significantly associated with increased likelihood of upgrading (p trend=0.022). Men with prostates 25 cm3 or less had more than 2.7 times the risk of disease being upgraded relative to men with TRUS volumes more than 40 cm3 (OR 2.718, 95% CI 1.403-8.126). Conclusion: In our study, smaller prostate volumes were at increased risk for GS upgrading after RP. This finding should be kept in mind when making treatment decisions for men with prostate cancer that appears to be of a low grade on biopsy, especially in Asian urologic fields.

Original languageEnglish
Pages (from-to)902-906
Number of pages5
JournalYonsei medical journal
Volume54
Issue number4
DOIs
Publication statusPublished - 2013 Jul 1

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Neoplasm Grading
Prostatectomy
Prostate
Biopsy
Medical Records
Prostatic Neoplasms
Decision Making
Logistic Models

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chung, Mun Su ; Lee, Seung Hwan ; Lee, Dong Hoon ; Chung, Byungha. / Is small prostate volume a predictor of gleason score upgrading after radical prostatectomy?. In: Yonsei medical journal. 2013 ; Vol. 54, No. 4. pp. 902-906.
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abstract = "Purpose: We aimed to analyze the relationship between prostate volume and Gleason score (GS) upgrading [higher GS category in the radical prostatectomy (RP) specimen than in the prostate biopsy] in Korean men. Materials and Methods: We retrospectively analyzed the medical records of 247 men who underwent RP between May 2006 and April 2011 at our institution. Transrectal ultrasound (TRUS) volume was categorized as 25 cm3 or less (n=61), 25 to 40 cm3 (n=121) and greater than 40 cm3 (n=65). GS was examined as a categorical variable of 6 or less, 3+4 and 4+3 or greater. The relationship between TRUS volume and upgrading of GS was analyzed using multivariate logistic regression. Results: Overall, 87 patients (35.2{\%}) were upgraded, 20 (8.1{\%}) were downgraded, and 140 (56.7{\%}) had identical biopsy and pathological Gleason sum groups. Smaller TRUS volume was significantly associated with increased likelihood of upgrading (p trend=0.022). Men with prostates 25 cm3 or less had more than 2.7 times the risk of disease being upgraded relative to men with TRUS volumes more than 40 cm3 (OR 2.718, 95{\%} CI 1.403-8.126). Conclusion: In our study, smaller prostate volumes were at increased risk for GS upgrading after RP. This finding should be kept in mind when making treatment decisions for men with prostate cancer that appears to be of a low grade on biopsy, especially in Asian urologic fields.",
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Is small prostate volume a predictor of gleason score upgrading after radical prostatectomy? / Chung, Mun Su; Lee, Seung Hwan; Lee, Dong Hoon; Chung, Byungha.

In: Yonsei medical journal, Vol. 54, No. 4, 01.07.2013, p. 902-906.

Research output: Contribution to journalArticle

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