Is there a sex-related difference in the obesity paradox in systolic heart failure? Sex-related difference in the obesity paradox

Soonchang Hong, Ji Hyun Lee, Kyung Min Kim, Junwon Lee, Youngjin Youn, Minsoo Ahn, Sung Gyun Ahn, Seunghwan Lee, Junghan Yoon, Kyung Hoon Choe, Byungsu Yoo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. Materials and Methods: We performed a pooled analysis of data from two multicenter, observational HF studies. Patients hospitalized for systolic HF were eligible for the present study. We divided the subjects into two groups, a normal body mass index (BMI) group and a high BMI group. Study endpoints included all-cause mortality and any re-hospitalization within 1 year. Results: We enrolled 3145 patients (male, 1824; female, 1321). The high BMI group was significantly associated with lower 1-year mortality rate [odds ratio (OR), 0.543; 95% confidence interval (CI), 0.355−0.832] after adjusting for age, hypertension, diabetes, ischemic HF, previous myocardial infarction, serum creatinine level, anemia, and ejection fraction in men. After adjustment for clinical characteristics, high BMI was not significantly associated with 1-year mortality (OR, 0.739; 95% CI, 0.450−1.216) or 1-year re-hospitalization (OR, 0.958; 95% CI, 0.696−1.319) in women. Conclusion: In pooled analysis of data from two Korean HF registries, the high BMI group was independently associated with lower 1-year mortality rate from systolic HF, especially in men.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalYonsei medical journal
Volume59
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Systolic Heart Failure
Sex Characteristics
Body Mass Index
Obesity
Heart Failure
Mortality
Odds Ratio
Confidence Intervals
Hospitalization
Registries
Anemia
Creatinine
Myocardial Infarction
Hypertension
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Is there a sex-related difference in the obesity paradox in systolic heart failure? Sex-related difference in the obesity paradox",
abstract = "Purpose: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. Materials and Methods: We performed a pooled analysis of data from two multicenter, observational HF studies. Patients hospitalized for systolic HF were eligible for the present study. We divided the subjects into two groups, a normal body mass index (BMI) group and a high BMI group. Study endpoints included all-cause mortality and any re-hospitalization within 1 year. Results: We enrolled 3145 patients (male, 1824; female, 1321). The high BMI group was significantly associated with lower 1-year mortality rate [odds ratio (OR), 0.543; 95{\%} confidence interval (CI), 0.355−0.832] after adjusting for age, hypertension, diabetes, ischemic HF, previous myocardial infarction, serum creatinine level, anemia, and ejection fraction in men. After adjustment for clinical characteristics, high BMI was not significantly associated with 1-year mortality (OR, 0.739; 95{\%} CI, 0.450−1.216) or 1-year re-hospitalization (OR, 0.958; 95{\%} CI, 0.696−1.319) in women. Conclusion: In pooled analysis of data from two Korean HF registries, the high BMI group was independently associated with lower 1-year mortality rate from systolic HF, especially in men.",
author = "Soonchang Hong and Lee, {Ji Hyun} and Kim, {Kyung Min} and Junwon Lee and Youngjin Youn and Minsoo Ahn and Ahn, {Sung Gyun} and Seunghwan Lee and Junghan Yoon and Choe, {Kyung Hoon} and Byungsu Yoo",
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Is there a sex-related difference in the obesity paradox in systolic heart failure? Sex-related difference in the obesity paradox. / Hong, Soonchang; Lee, Ji Hyun; Kim, Kyung Min; Lee, Junwon; Youn, Youngjin; Ahn, Minsoo; Ahn, Sung Gyun; Lee, Seunghwan; Yoon, Junghan; Choe, Kyung Hoon; Yoo, Byungsu.

In: Yonsei medical journal, Vol. 59, No. 1, 01.01.2018, p. 57-62.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Is there a sex-related difference in the obesity paradox in systolic heart failure? Sex-related difference in the obesity paradox

AU - Hong, Soonchang

AU - Lee, Ji Hyun

AU - Kim, Kyung Min

AU - Lee, Junwon

AU - Youn, Youngjin

AU - Ahn, Minsoo

AU - Ahn, Sung Gyun

AU - Lee, Seunghwan

AU - Yoon, Junghan

AU - Choe, Kyung Hoon

AU - Yoo, Byungsu

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. Materials and Methods: We performed a pooled analysis of data from two multicenter, observational HF studies. Patients hospitalized for systolic HF were eligible for the present study. We divided the subjects into two groups, a normal body mass index (BMI) group and a high BMI group. Study endpoints included all-cause mortality and any re-hospitalization within 1 year. Results: We enrolled 3145 patients (male, 1824; female, 1321). The high BMI group was significantly associated with lower 1-year mortality rate [odds ratio (OR), 0.543; 95% confidence interval (CI), 0.355−0.832] after adjusting for age, hypertension, diabetes, ischemic HF, previous myocardial infarction, serum creatinine level, anemia, and ejection fraction in men. After adjustment for clinical characteristics, high BMI was not significantly associated with 1-year mortality (OR, 0.739; 95% CI, 0.450−1.216) or 1-year re-hospitalization (OR, 0.958; 95% CI, 0.696−1.319) in women. Conclusion: In pooled analysis of data from two Korean HF registries, the high BMI group was independently associated with lower 1-year mortality rate from systolic HF, especially in men.

AB - Purpose: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. Materials and Methods: We performed a pooled analysis of data from two multicenter, observational HF studies. Patients hospitalized for systolic HF were eligible for the present study. We divided the subjects into two groups, a normal body mass index (BMI) group and a high BMI group. Study endpoints included all-cause mortality and any re-hospitalization within 1 year. Results: We enrolled 3145 patients (male, 1824; female, 1321). The high BMI group was significantly associated with lower 1-year mortality rate [odds ratio (OR), 0.543; 95% confidence interval (CI), 0.355−0.832] after adjusting for age, hypertension, diabetes, ischemic HF, previous myocardial infarction, serum creatinine level, anemia, and ejection fraction in men. After adjustment for clinical characteristics, high BMI was not significantly associated with 1-year mortality (OR, 0.739; 95% CI, 0.450−1.216) or 1-year re-hospitalization (OR, 0.958; 95% CI, 0.696−1.319) in women. Conclusion: In pooled analysis of data from two Korean HF registries, the high BMI group was independently associated with lower 1-year mortality rate from systolic HF, especially in men.

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