Is US-guided core needle biopsy (CNB) enough in probably benign nodules with interval growth?

J. H. Yoon, Eunkyung Kim, jinyoung kwak, H. J. Moon, minjung Kim

Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate whether ultrasound-guided 14-gauge core needle biopsy (US-CNB) is efficient in the diagnosis of probably benign lesions showing interval growth on follow-up US. Materials and Methods: From March 2008 to August 2009, 116 breast lesions in 113 women (mean age: 41.2 years, range: 19-63 years) which were initially assessed as category 3 showing interval growth on follow-up US underwent US-CNB, and subsequent US-guided vacuum-assisted excision, surgical excision or follow-up US for at least 12 months. Diagnostic performances of US-CNB were evaluated with histopathologic results and follow-up US as standard reference. Clinical features of the patient and lesions characteristics including follow-up interval (I), the most increased diameter (D), D per I, increased volume (%V) and %V per I were calculated and compared. Results: Of the 116 lesions, 4 lesions were diagnosed as malignancy and 112 as benign on final pathology. Malignancy rate of probably benign lesions showing interval growth was 3.4% (4/116). Incorrect biopsy rate was 0.9% (1/116). Palpability or newly developed suspicious US features were more associated with malignancy, 75.0 to 13.4% and 50.0 to 25.9%, respectively, but without significance (p=0.063 and 0.290). Significant differences were seen in average rank when comparing between benign and malignancy in D, %V, D per follow-up interval (I), and %V/I (p=0.037, 0.017, 0.043 and 0.009, respectively). Conclusion: US-CNB is an efficient diagnostic method for probably benign lesions showing interval growth, with discordant biopsy rate of 0.9%.

Original languageEnglish
JournalUltraschall in der Medizin
Volume33
Issue number7
DOIs
Publication statusPublished - 2012 Oct 1

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Large-Core Needle Biopsy
Growth
Neoplasms
Biopsy
Vacuum
Ultrasonography
Breast
Pathology

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

@article{a028480890d14c5995655ec60754f137,
title = "Is US-guided core needle biopsy (CNB) enough in probably benign nodules with interval growth?",
abstract = "Purpose: To investigate whether ultrasound-guided 14-gauge core needle biopsy (US-CNB) is efficient in the diagnosis of probably benign lesions showing interval growth on follow-up US. Materials and Methods: From March 2008 to August 2009, 116 breast lesions in 113 women (mean age: 41.2 years, range: 19-63 years) which were initially assessed as category 3 showing interval growth on follow-up US underwent US-CNB, and subsequent US-guided vacuum-assisted excision, surgical excision or follow-up US for at least 12 months. Diagnostic performances of US-CNB were evaluated with histopathologic results and follow-up US as standard reference. Clinical features of the patient and lesions characteristics including follow-up interval (I), the most increased diameter (D), D per I, increased volume ({\%}V) and {\%}V per I were calculated and compared. Results: Of the 116 lesions, 4 lesions were diagnosed as malignancy and 112 as benign on final pathology. Malignancy rate of probably benign lesions showing interval growth was 3.4{\%} (4/116). Incorrect biopsy rate was 0.9{\%} (1/116). Palpability or newly developed suspicious US features were more associated with malignancy, 75.0 to 13.4{\%} and 50.0 to 25.9{\%}, respectively, but without significance (p=0.063 and 0.290). Significant differences were seen in average rank when comparing between benign and malignancy in D, {\%}V, D per follow-up interval (I), and {\%}V/I (p=0.037, 0.017, 0.043 and 0.009, respectively). Conclusion: US-CNB is an efficient diagnostic method for probably benign lesions showing interval growth, with discordant biopsy rate of 0.9{\%}.",
author = "Yoon, {J. H.} and Eunkyung Kim and jinyoung kwak and Moon, {H. J.} and minjung Kim",
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Is US-guided core needle biopsy (CNB) enough in probably benign nodules with interval growth? / Yoon, J. H.; Kim, Eunkyung; kwak, jinyoung; Moon, H. J.; Kim, minjung.

In: Ultraschall in der Medizin, Vol. 33, No. 7, 01.10.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Is US-guided core needle biopsy (CNB) enough in probably benign nodules with interval growth?

AU - Yoon, J. H.

AU - Kim, Eunkyung

AU - kwak, jinyoung

AU - Moon, H. J.

AU - Kim, minjung

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Purpose: To investigate whether ultrasound-guided 14-gauge core needle biopsy (US-CNB) is efficient in the diagnosis of probably benign lesions showing interval growth on follow-up US. Materials and Methods: From March 2008 to August 2009, 116 breast lesions in 113 women (mean age: 41.2 years, range: 19-63 years) which were initially assessed as category 3 showing interval growth on follow-up US underwent US-CNB, and subsequent US-guided vacuum-assisted excision, surgical excision or follow-up US for at least 12 months. Diagnostic performances of US-CNB were evaluated with histopathologic results and follow-up US as standard reference. Clinical features of the patient and lesions characteristics including follow-up interval (I), the most increased diameter (D), D per I, increased volume (%V) and %V per I were calculated and compared. Results: Of the 116 lesions, 4 lesions were diagnosed as malignancy and 112 as benign on final pathology. Malignancy rate of probably benign lesions showing interval growth was 3.4% (4/116). Incorrect biopsy rate was 0.9% (1/116). Palpability or newly developed suspicious US features were more associated with malignancy, 75.0 to 13.4% and 50.0 to 25.9%, respectively, but without significance (p=0.063 and 0.290). Significant differences were seen in average rank when comparing between benign and malignancy in D, %V, D per follow-up interval (I), and %V/I (p=0.037, 0.017, 0.043 and 0.009, respectively). Conclusion: US-CNB is an efficient diagnostic method for probably benign lesions showing interval growth, with discordant biopsy rate of 0.9%.

AB - Purpose: To investigate whether ultrasound-guided 14-gauge core needle biopsy (US-CNB) is efficient in the diagnosis of probably benign lesions showing interval growth on follow-up US. Materials and Methods: From March 2008 to August 2009, 116 breast lesions in 113 women (mean age: 41.2 years, range: 19-63 years) which were initially assessed as category 3 showing interval growth on follow-up US underwent US-CNB, and subsequent US-guided vacuum-assisted excision, surgical excision or follow-up US for at least 12 months. Diagnostic performances of US-CNB were evaluated with histopathologic results and follow-up US as standard reference. Clinical features of the patient and lesions characteristics including follow-up interval (I), the most increased diameter (D), D per I, increased volume (%V) and %V per I were calculated and compared. Results: Of the 116 lesions, 4 lesions were diagnosed as malignancy and 112 as benign on final pathology. Malignancy rate of probably benign lesions showing interval growth was 3.4% (4/116). Incorrect biopsy rate was 0.9% (1/116). Palpability or newly developed suspicious US features were more associated with malignancy, 75.0 to 13.4% and 50.0 to 25.9%, respectively, but without significance (p=0.063 and 0.290). Significant differences were seen in average rank when comparing between benign and malignancy in D, %V, D per follow-up interval (I), and %V/I (p=0.037, 0.017, 0.043 and 0.009, respectively). Conclusion: US-CNB is an efficient diagnostic method for probably benign lesions showing interval growth, with discordant biopsy rate of 0.9%.

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U2 - 10.1055/s-0032-1313208

DO - 10.1055/s-0032-1313208

M3 - Article

VL - 33

JO - Ultraschall in der Medizin

JF - Ultraschall in der Medizin

SN - 0172-4614

IS - 7

ER -