Is uterine artery embolization for patients with large myomas safe and effective? A retrospective comparative study in 323 patients

Hye Jeong Choi, Gyeong Sik Jeon, ManDeuk Kim, Jong Tae Lee, Jung Hyun Yoon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: To evaluate the effectiveness, safety, and complications of uterine artery embolization (UAE) in women with large fibroid tumors. Materials and Methods: From January 2005 to February 2011, 323 patients underwent UAE for symptomatic uterine leiomyomas without adenomyosis and were included in this study. Patients were divided into two groups: those with a large tumor burden (group 1; n = 63), defined as a dominant tumor with a longest axis of at least 10 cm or a uterine volume of at least 700 cm3; and the control group (group 2; n = 260). Tumor infarction and volume reduction were calculated based on magnetic resonance imaging findings. Symptom status was assessed with a visual analog scale. Postprocedure complications and repeat interventions were recorded. The data were analyzed with appropriate statistical tests. Results: No significant differences were seen between the two groups in volume reduction of dominant tumors (46.5% in group 1 vs 52.0% in group 2; P =.082) or percentage volume reduction of the uterus (40.7% in group 1 vs 36.3% in group 2; P =.114). Also, no significant differences were seen between the two groups regarding satisfaction scores at immediate or midterm follow-up (P =.524 and P =.497) or in the presence of procedure-related complications (P =.193). Conclusions: UAE outcomes in large fibroid tumors were comparable to those in smaller tumors, without an increased risk of significant complications. Tumor size may not be a key factor in predicting successful outcomes of UAE.

Original languageEnglish
Pages (from-to)772-778
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Volume24
Issue number6
DOIs
Publication statusPublished - 2013 Jun 1

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Uterine Artery Embolization
Myoma
Leiomyoma
Retrospective Studies
Tumor Burden
Neoplasms
Adenomyosis
Visual Analog Scale
Infarction
Uterus
Magnetic Resonance Imaging
Safety
Control Groups

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{4dae29d348c240078c3fd87c25c68be1,
title = "Is uterine artery embolization for patients with large myomas safe and effective? A retrospective comparative study in 323 patients",
abstract = "Purpose: To evaluate the effectiveness, safety, and complications of uterine artery embolization (UAE) in women with large fibroid tumors. Materials and Methods: From January 2005 to February 2011, 323 patients underwent UAE for symptomatic uterine leiomyomas without adenomyosis and were included in this study. Patients were divided into two groups: those with a large tumor burden (group 1; n = 63), defined as a dominant tumor with a longest axis of at least 10 cm or a uterine volume of at least 700 cm3; and the control group (group 2; n = 260). Tumor infarction and volume reduction were calculated based on magnetic resonance imaging findings. Symptom status was assessed with a visual analog scale. Postprocedure complications and repeat interventions were recorded. The data were analyzed with appropriate statistical tests. Results: No significant differences were seen between the two groups in volume reduction of dominant tumors (46.5{\%} in group 1 vs 52.0{\%} in group 2; P =.082) or percentage volume reduction of the uterus (40.7{\%} in group 1 vs 36.3{\%} in group 2; P =.114). Also, no significant differences were seen between the two groups regarding satisfaction scores at immediate or midterm follow-up (P =.524 and P =.497) or in the presence of procedure-related complications (P =.193). Conclusions: UAE outcomes in large fibroid tumors were comparable to those in smaller tumors, without an increased risk of significant complications. Tumor size may not be a key factor in predicting successful outcomes of UAE.",
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Is uterine artery embolization for patients with large myomas safe and effective? A retrospective comparative study in 323 patients. / Choi, Hye Jeong; Jeon, Gyeong Sik; Kim, ManDeuk; Tae Lee, Jong; Hyun Yoon, Jung.

In: Journal of Vascular and Interventional Radiology, Vol. 24, No. 6, 01.06.2013, p. 772-778.

Research output: Contribution to journalArticle

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AU - Jeon, Gyeong Sik

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AU - Hyun Yoon, Jung

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N2 - Purpose: To evaluate the effectiveness, safety, and complications of uterine artery embolization (UAE) in women with large fibroid tumors. Materials and Methods: From January 2005 to February 2011, 323 patients underwent UAE for symptomatic uterine leiomyomas without adenomyosis and were included in this study. Patients were divided into two groups: those with a large tumor burden (group 1; n = 63), defined as a dominant tumor with a longest axis of at least 10 cm or a uterine volume of at least 700 cm3; and the control group (group 2; n = 260). Tumor infarction and volume reduction were calculated based on magnetic resonance imaging findings. Symptom status was assessed with a visual analog scale. Postprocedure complications and repeat interventions were recorded. The data were analyzed with appropriate statistical tests. Results: No significant differences were seen between the two groups in volume reduction of dominant tumors (46.5% in group 1 vs 52.0% in group 2; P =.082) or percentage volume reduction of the uterus (40.7% in group 1 vs 36.3% in group 2; P =.114). Also, no significant differences were seen between the two groups regarding satisfaction scores at immediate or midterm follow-up (P =.524 and P =.497) or in the presence of procedure-related complications (P =.193). Conclusions: UAE outcomes in large fibroid tumors were comparable to those in smaller tumors, without an increased risk of significant complications. Tumor size may not be a key factor in predicting successful outcomes of UAE.

AB - Purpose: To evaluate the effectiveness, safety, and complications of uterine artery embolization (UAE) in women with large fibroid tumors. Materials and Methods: From January 2005 to February 2011, 323 patients underwent UAE for symptomatic uterine leiomyomas without adenomyosis and were included in this study. Patients were divided into two groups: those with a large tumor burden (group 1; n = 63), defined as a dominant tumor with a longest axis of at least 10 cm or a uterine volume of at least 700 cm3; and the control group (group 2; n = 260). Tumor infarction and volume reduction were calculated based on magnetic resonance imaging findings. Symptom status was assessed with a visual analog scale. Postprocedure complications and repeat interventions were recorded. The data were analyzed with appropriate statistical tests. Results: No significant differences were seen between the two groups in volume reduction of dominant tumors (46.5% in group 1 vs 52.0% in group 2; P =.082) or percentage volume reduction of the uterus (40.7% in group 1 vs 36.3% in group 2; P =.114). Also, no significant differences were seen between the two groups regarding satisfaction scores at immediate or midterm follow-up (P =.524 and P =.497) or in the presence of procedure-related complications (P =.193). Conclusions: UAE outcomes in large fibroid tumors were comparable to those in smaller tumors, without an increased risk of significant complications. Tumor size may not be a key factor in predicting successful outcomes of UAE.

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