Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110

Hee Jae Shin, Hyun Sun Jeong, Hyi Seung Lee, Song Kyu Park, Hwan Mook Kim, Ho Jeong Kwon

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines.

Original languageEnglish
Pages (from-to)1403-1406
Number of pages4
JournalJournal of microbiology and biotechnology
Volume17
Issue number8
Publication statusPublished - 2007 Aug 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

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