Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110

Hee Jae Shin; Hyun Sun Jeong; Hyi Seung Lee; Song Kyu Park; Hwan Mook Kim; Ho Jeong Kwon

Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110

Hee Jae Shin, Hyun Sun Jeong, Hyi Seung Lee, Song Kyu Park, Hwan Mook Kim, Ho Jeong Kwon

Research output: Contribution to journal › Article › peer-review

Abstract

An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines.

Original language	English
Pages (from-to)	1403-1406
Number of pages	4
Journal	Journal of microbiology and biotechnology
Volume	17
Issue number	8
Publication status	Published - 2007 Aug

All Science Journal Classification (ASJC) codes

Biotechnology
Applied Microbiology and Biotechnology

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title = "Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110",

abstract = "An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines.",

author = "Shin, {Hee Jae} and Jeong, {Hyun Sun} and Lee, {Hyi Seung} and Park, {Song Kyu} and Kim, {Hwan Mook} and Kwon, {Ho Jeong}",

year = "2007",

month = aug,

language = "English",

volume = "17",

pages = "1403--1406",

journal = "Journal of Microbiology and Biotechnology",

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publisher = "Korean Society for Microbiolog and Biotechnology",

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T1 - Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110

AU - Shin, Hee Jae

AU - Jeong, Hyun Sun

AU - Lee, Hyi Seung

AU - Park, Song Kyu

AU - Kim, Hwan Mook

AU - Kwon, Ho Jeong

PY - 2007/8

Y1 - 2007/8

N2 - An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines.

AB - An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines.

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JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

IS - 8

ER -

Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp. 04DH110

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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