Isolation and structure elucidation of (-)-idescarparide, a new spiro compound from Idesia polycarpa

Tae Bum Kim, Hyeon Woo Kim, Mina Lee, Hyang Hwa Lee, Seung Hyun Kim, Sung Kwon Kang, Sang Hyun Sung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

(-)-Idescarparide, a new spiro compound possessing a tetrahydrobenzodioxole structure from the fruit of Idesia polycarpa Maxim. was identified to be a dimer of (-)-idescarpin by spectroscopic analysis. The absolute configuration of (-)-idescarpin was firstly determined to be of S form by using single-crystal X-ray diffraction. The absolute configuration of (-)-idescarparide was confirmed by comparison with semi-synthetic (-)-idescarparide, achieved via triethylamine-catalyzed dimerization of (-)-idescarpin. (-)-Idescarparide significantly reduced lipid production in 3T3-L1 cells.

Original languageEnglish
Pages (from-to)5447-5449
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number40
DOIs
Publication statusPublished - 2014 Oct 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Isolation and structure elucidation of (-)-idescarparide, a new spiro compound from Idesia polycarpa'. Together they form a unique fingerprint.

  • Cite this