Isolation of amylase regulators from the leaves of Ixeridium dentatum

Seon Ju Park, Nguyen Xuan Nhiem, Jun Hyung Park, Kashi Raj Bhattarai, Han Jung Chae, Hyung Ryong Kim, Seung Hyun Kim

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1 Citation (Scopus)


Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.

Original languageEnglish
Pages (from-to)744-749
Number of pages6
JournalNatural Product Research
Issue number5
Publication statusPublished - 2021

Bibliographical note

Funding Information:
This work was supported by the “Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ01158104)” Rural Development Administration, Republic of Korea and Basic Research Infrastructure Support Program (University-Centered Labs-2018R1A6A1A03023718) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning, Republic of Korea.

Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry


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