Isolation of amylase regulators from the leaves of Ixeridium dentatum

Seon Ju Park, Nguyen Xuan Nhiem, Jun Hyung Park, Kashi Raj Bhattarai, Han Jung Chae, Hyung Ryong Kim, Seung Hyun Kim

Research output: Contribution to journalArticle

Abstract

Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Amylases
amylases
secretion
Luteolin
leaves
Sesquiterpenes
luteolin
sesquiterpenoid lactones
Quercetin
Lactones
salivary glands
Salivary Glands
Human Activities
quercetin
Mass spectrometry
Mass Spectrometry
Nuclear magnetic resonance
mass spectrometry
Glucose
glucose

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Cite this

Park, Seon Ju ; Nhiem, Nguyen Xuan ; Park, Jun Hyung ; Bhattarai, Kashi Raj ; Chae, Han Jung ; Kim, Hyung Ryong ; Kim, Seung Hyun. / Isolation of amylase regulators from the leaves of Ixeridium dentatum. In: Natural Product Research. 2019.
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Isolation of amylase regulators from the leaves of Ixeridium dentatum. / Park, Seon Ju; Nhiem, Nguyen Xuan; Park, Jun Hyung; Bhattarai, Kashi Raj; Chae, Han Jung; Kim, Hyung Ryong; Kim, Seung Hyun.

In: Natural Product Research, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Nhiem, Nguyen Xuan

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