Abstract
Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.
| Original language | English |
|---|---|
| Journal | Natural Product Research |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Biochemistry
- Plant Science
- Organic Chemistry
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Isolation of amylase regulators from the leaves of Ixeridium dentatum. / Park, Seon Ju; Nhiem, Nguyen Xuan; Park, Jun Hyung; Bhattarai, Kashi Raj; Chae, Han Jung; Kim, Hyung Ryong; Kim, Seung Hyun.
In: Natural Product Research, 01.01.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Isolation of amylase regulators from the leaves of Ixeridium dentatum
AU - Park, Seon Ju
AU - Nhiem, Nguyen Xuan
AU - Park, Jun Hyung
AU - Bhattarai, Kashi Raj
AU - Chae, Han Jung
AU - Kim, Hyung Ryong
AU - Kim, Seung Hyun
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.
AB - Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.
UR - http://www.scopus.com/inward/record.url?scp=85064164403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064164403&partnerID=8YFLogxK
U2 - 10.1080/14786419.2019.1599885
DO - 10.1080/14786419.2019.1599885
M3 - Article
AN - SCOPUS:85064164403
JO - Natural Product Research
JF - Natural Product Research
SN - 1478-6419
ER -