Isolation of amylase regulators from the leaves of Ixeridium dentatum

Seon Ju Park; Nguyen Xuan Nhiem; Jun Hyung Park; Kashi Raj Bhattarai; Han Jung Chae; Hyung Ryong Kim; Seung Hyun Kim

doi:10.1080/14786419.2019.1599885

Isolation of amylase regulators from the leaves of Ixeridium dentatum

Seon Ju Park, Nguyen Xuan Nhiem, Jun Hyung Park, Kashi Raj Bhattarai, Han Jung Chae, Hyung Ryong Kim, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article

Abstract

Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.

Original language	English
Journal	Natural Product Research
DOIs	https://doi.org/10.1080/14786419.2019.1599885
Publication status	Published - 2019 Jan 1

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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Park, S. J., Nhiem, N. X., Park, J. H., Bhattarai, K. R., Chae, H. J., Kim, H. R., & Kim, S. H. (2019). Isolation of amylase regulators from the leaves of Ixeridium dentatum. Natural Product Research. https://doi.org/10.1080/14786419.2019.1599885

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abstract = "Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.",

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AU - Chae, Han Jung

AU - Kim, Hyung Ryong

AU - Kim, Seung Hyun

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