Isolation of amylase regulators from the leaves of Ixeridium dentatum

Seon Ju Park, Nguyen Xuan Nhiem, Jun Hyung Park, Kashi Raj Bhattarai, Han Jung Chae, Hyung Ryong Kim, Seung Hyun Kim

Research output: Contribution to journalArticle


Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.

Original languageEnglish
JournalNatural Product Research
Publication statusPublished - 2019 Jan 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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