Isolation of nontuberculous mycobacteria by DNA probe and clinical characteristics of patients with NTM pulmonary disease

Hee Kyoo Kim, Yu Ri Kim, Jung Pil Park, Nang Hee Kim, Chul Ho Ok, Maan Hong Jung, Tae Won Jang, Seok Hoon Jeong, Cheol Min Kim, Hee Kyung Park

Research output: Contribution to journalArticle

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Abstract

Background: Nontuberculous mycobacterial (NTM) infections are increasingly being recognized as a cause of chronic pulmonary disease. This study describes the prevalence of NTM species from clinical specimens and the clinical characteristics of NTM pulmonary disease. Material and Methods: The NTM isolated from March 2003 to December 2003 at the Kosin Medical Center were identified using an oligonucleotide chip containing the internal transcribed space (ITS) sequence. The medical records of the patients with the NTM isolates, who fulfilled the 1997 ATS diagnostic criteria for NTM pulmonary disease, were analyzed, retrospectively. Results: Twenty four species (24.2%) of NTM were isolated from 99 cultured AFB specimens. M. avium complex (MAC) (13 isolates), M. szulgai (3), M. kansasii (2), M. malmoense (2), M. abscessus (1), M. chelonae (1), M. scrofulaceum (1), and unclassified (1). Of the 23 patients with isolated NTM, 11 patients were found to be compatible with a NTM pulmonary infection according to the ATS criteria; MAC was found in 6 cases (54.5%), M. szulgai in 2 cases (18.2%), and M. abscessus, M. szulgai, M. kansasii and M. malmoense in 1 case each (9.1%). Ten patients (91%) were male and the median age at diagnosis was 61 years. In the pre-existing diseases, malignant disease was found in 6 cases including 5 patients with lung cancer, and history of old pulmonary tuberculosis was identified in 4 cases. The radiological patterns showed lung destruction lung in 3 cases, a cavitary mass in 3 cases, a nodular pattern in 2 cases, and reticulonodular, consolidation and a bronchiectasis pattern were in 1 case each. Conclusion: Various types of NTM pulmonary diseases were found in a tertiary hospital at Busan, Korea. The NTM pulmonary diseases were caused by AMC, M. szagai, M. kansasii, M. malmoense, M. abscessus, M. chelonae, and M. scrofulaceum in the order of frequency.

Original languageEnglish
Pages (from-to)248-256
Number of pages9
JournalTuberculosis and Respiratory Diseases
Volume58
Issue number3
Publication statusPublished - 2005 Mar 1

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Nontuberculous Mycobacteria
DNA Probes
Lung Diseases
Lung
Preexisting Condition Coverage
Bronchiectasis
Korea
Infection
Pulmonary Tuberculosis
Tertiary Care Centers
Oligonucleotides
Medical Records
Lung Neoplasms
Chronic Disease
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Kim, H. K., Kim, Y. R., Park, J. P., Kim, N. H., Ok, C. H., Jung, M. H., ... Park, H. K. (2005). Isolation of nontuberculous mycobacteria by DNA probe and clinical characteristics of patients with NTM pulmonary disease. Tuberculosis and Respiratory Diseases, 58(3), 248-256.
Kim, Hee Kyoo ; Kim, Yu Ri ; Park, Jung Pil ; Kim, Nang Hee ; Ok, Chul Ho ; Jung, Maan Hong ; Jang, Tae Won ; Jeong, Seok Hoon ; Kim, Cheol Min ; Park, Hee Kyung. / Isolation of nontuberculous mycobacteria by DNA probe and clinical characteristics of patients with NTM pulmonary disease. In: Tuberculosis and Respiratory Diseases. 2005 ; Vol. 58, No. 3. pp. 248-256.
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title = "Isolation of nontuberculous mycobacteria by DNA probe and clinical characteristics of patients with NTM pulmonary disease",
abstract = "Background: Nontuberculous mycobacterial (NTM) infections are increasingly being recognized as a cause of chronic pulmonary disease. This study describes the prevalence of NTM species from clinical specimens and the clinical characteristics of NTM pulmonary disease. Material and Methods: The NTM isolated from March 2003 to December 2003 at the Kosin Medical Center were identified using an oligonucleotide chip containing the internal transcribed space (ITS) sequence. The medical records of the patients with the NTM isolates, who fulfilled the 1997 ATS diagnostic criteria for NTM pulmonary disease, were analyzed, retrospectively. Results: Twenty four species (24.2{\%}) of NTM were isolated from 99 cultured AFB specimens. M. avium complex (MAC) (13 isolates), M. szulgai (3), M. kansasii (2), M. malmoense (2), M. abscessus (1), M. chelonae (1), M. scrofulaceum (1), and unclassified (1). Of the 23 patients with isolated NTM, 11 patients were found to be compatible with a NTM pulmonary infection according to the ATS criteria; MAC was found in 6 cases (54.5{\%}), M. szulgai in 2 cases (18.2{\%}), and M. abscessus, M. szulgai, M. kansasii and M. malmoense in 1 case each (9.1{\%}). Ten patients (91{\%}) were male and the median age at diagnosis was 61 years. In the pre-existing diseases, malignant disease was found in 6 cases including 5 patients with lung cancer, and history of old pulmonary tuberculosis was identified in 4 cases. The radiological patterns showed lung destruction lung in 3 cases, a cavitary mass in 3 cases, a nodular pattern in 2 cases, and reticulonodular, consolidation and a bronchiectasis pattern were in 1 case each. Conclusion: Various types of NTM pulmonary diseases were found in a tertiary hospital at Busan, Korea. The NTM pulmonary diseases were caused by AMC, M. szagai, M. kansasii, M. malmoense, M. abscessus, M. chelonae, and M. scrofulaceum in the order of frequency.",
author = "Kim, {Hee Kyoo} and Kim, {Yu Ri} and Park, {Jung Pil} and Kim, {Nang Hee} and Ok, {Chul Ho} and Jung, {Maan Hong} and Jang, {Tae Won} and Jeong, {Seok Hoon} and Kim, {Cheol Min} and Park, {Hee Kyung}",
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Kim, HK, Kim, YR, Park, JP, Kim, NH, Ok, CH, Jung, MH, Jang, TW, Jeong, SH, Kim, CM & Park, HK 2005, 'Isolation of nontuberculous mycobacteria by DNA probe and clinical characteristics of patients with NTM pulmonary disease', Tuberculosis and Respiratory Diseases, vol. 58, no. 3, pp. 248-256.

Isolation of nontuberculous mycobacteria by DNA probe and clinical characteristics of patients with NTM pulmonary disease. / Kim, Hee Kyoo; Kim, Yu Ri; Park, Jung Pil; Kim, Nang Hee; Ok, Chul Ho; Jung, Maan Hong; Jang, Tae Won; Jeong, Seok Hoon; Kim, Cheol Min; Park, Hee Kyung.

In: Tuberculosis and Respiratory Diseases, Vol. 58, No. 3, 01.03.2005, p. 248-256.

Research output: Contribution to journalArticle

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AU - Kim, Hee Kyoo

AU - Kim, Yu Ri

AU - Park, Jung Pil

AU - Kim, Nang Hee

AU - Ok, Chul Ho

AU - Jung, Maan Hong

AU - Jang, Tae Won

AU - Jeong, Seok Hoon

AU - Kim, Cheol Min

AU - Park, Hee Kyung

PY - 2005/3/1

Y1 - 2005/3/1

N2 - Background: Nontuberculous mycobacterial (NTM) infections are increasingly being recognized as a cause of chronic pulmonary disease. This study describes the prevalence of NTM species from clinical specimens and the clinical characteristics of NTM pulmonary disease. Material and Methods: The NTM isolated from March 2003 to December 2003 at the Kosin Medical Center were identified using an oligonucleotide chip containing the internal transcribed space (ITS) sequence. The medical records of the patients with the NTM isolates, who fulfilled the 1997 ATS diagnostic criteria for NTM pulmonary disease, were analyzed, retrospectively. Results: Twenty four species (24.2%) of NTM were isolated from 99 cultured AFB specimens. M. avium complex (MAC) (13 isolates), M. szulgai (3), M. kansasii (2), M. malmoense (2), M. abscessus (1), M. chelonae (1), M. scrofulaceum (1), and unclassified (1). Of the 23 patients with isolated NTM, 11 patients were found to be compatible with a NTM pulmonary infection according to the ATS criteria; MAC was found in 6 cases (54.5%), M. szulgai in 2 cases (18.2%), and M. abscessus, M. szulgai, M. kansasii and M. malmoense in 1 case each (9.1%). Ten patients (91%) were male and the median age at diagnosis was 61 years. In the pre-existing diseases, malignant disease was found in 6 cases including 5 patients with lung cancer, and history of old pulmonary tuberculosis was identified in 4 cases. The radiological patterns showed lung destruction lung in 3 cases, a cavitary mass in 3 cases, a nodular pattern in 2 cases, and reticulonodular, consolidation and a bronchiectasis pattern were in 1 case each. Conclusion: Various types of NTM pulmonary diseases were found in a tertiary hospital at Busan, Korea. The NTM pulmonary diseases were caused by AMC, M. szagai, M. kansasii, M. malmoense, M. abscessus, M. chelonae, and M. scrofulaceum in the order of frequency.

AB - Background: Nontuberculous mycobacterial (NTM) infections are increasingly being recognized as a cause of chronic pulmonary disease. This study describes the prevalence of NTM species from clinical specimens and the clinical characteristics of NTM pulmonary disease. Material and Methods: The NTM isolated from March 2003 to December 2003 at the Kosin Medical Center were identified using an oligonucleotide chip containing the internal transcribed space (ITS) sequence. The medical records of the patients with the NTM isolates, who fulfilled the 1997 ATS diagnostic criteria for NTM pulmonary disease, were analyzed, retrospectively. Results: Twenty four species (24.2%) of NTM were isolated from 99 cultured AFB specimens. M. avium complex (MAC) (13 isolates), M. szulgai (3), M. kansasii (2), M. malmoense (2), M. abscessus (1), M. chelonae (1), M. scrofulaceum (1), and unclassified (1). Of the 23 patients with isolated NTM, 11 patients were found to be compatible with a NTM pulmonary infection according to the ATS criteria; MAC was found in 6 cases (54.5%), M. szulgai in 2 cases (18.2%), and M. abscessus, M. szulgai, M. kansasii and M. malmoense in 1 case each (9.1%). Ten patients (91%) were male and the median age at diagnosis was 61 years. In the pre-existing diseases, malignant disease was found in 6 cases including 5 patients with lung cancer, and history of old pulmonary tuberculosis was identified in 4 cases. The radiological patterns showed lung destruction lung in 3 cases, a cavitary mass in 3 cases, a nodular pattern in 2 cases, and reticulonodular, consolidation and a bronchiectasis pattern were in 1 case each. Conclusion: Various types of NTM pulmonary diseases were found in a tertiary hospital at Busan, Korea. The NTM pulmonary diseases were caused by AMC, M. szagai, M. kansasii, M. malmoense, M. abscessus, M. chelonae, and M. scrofulaceum in the order of frequency.

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