Isolation of two new bioactive sesquiterpene lactone glycosides from the roots of Ixeris dentata

Seonju Park, Nguyen Xuan Nhiem, Taek Hwan Lee, Nanyoung Kim, Sun Yeou Kim, Han Jung Chae, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Two new sesquiterpene lactone glycosides, 3-O-β-d-glucopyranosyl-8-hydroxy-(1,5,6,7,11)-guaia-3,10(14)-dien-12,6-olide (1) and 3-O-β-d-glucopyranosyl-8-(4-hydroxyphenylacetyloxy)-(1.5.6,7)-guaia-3,10(14),11(13)-trien-12,6-olide (2), and 12 known sesquiterpene lactone derivatives (3-14) were isolated from the roots of Ixeris dentata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR and MS spectra data. All compounds were tested for their ability to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cell. 3-O-β-d-Glucopyranosyl-8-(4-hydroxyphenylacetyloxy)-(1.5.6,7)-guaia-3,10(14),11(13)-trien-12,6-olide (2) showed the most potent inhibitory activity at a concentration of 20 μM.

Original languageEnglish
Pages (from-to)4562-4566
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number20
DOIs
Publication statusPublished - 2015 Oct 15

Bibliographical note

Funding Information:
This work was carried out with the support of Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ01158104) funded by the Rural Development Administration, Republic of Korea and of Basic Science Research Program through the National Research Foundation of Korea (NRF) (NRF-2011-0025129) funded by the Ministry of Education, Science and Technology , Republic of Korea.

Publisher Copyright:
© 2015 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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