Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China

Guangzhou Birth Cohort Study

Meng Li, Xiao Wen Zeng, Zhengmin (Min) Qian, Michael George Vaughn, Sébastien Sauvé, Gunther Paul, Shao Lin, Long Lu, Li Wen Hu, Bo Yi Yang, Yang Zhou, Xiao Di Qin, Shu Li Xu, Wen Wen Bao, Ya Zhi Zhang, Ping Yuan, Jia Wang, Chuan Zhang, Yan Peng Tian, Min Nian & 3 others Xiang Xiao, Chuanxi Fu, Guang Hui Dong

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China. High performance liquid chromatography-mass spectrometry was utilized to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) along with other PFAS levels in cord serum samples. Mothers’ and infants’ characteristics were gathered from medical records. The resulting data revealed that higher PFOS, PFOA and isomers of PFOS were associated with lower birth weight. Per ln-unit (ng/mL) increase in cord serum total branched PFOS isomers was associated with a 126.3 g (95% CI: − 195.9, − 56.8) reduction in the weight of infants at birth, while an ln-unit (ng/mL) increase of serum linear PFOS isomers (n-PFOS) was associated with a 57.2 g (95% CI: − 103.1, − 11.3) reduction in the weight of infants at birth upon the subsequent adjustment for potential confounding variables. Notably, the association between cord PFAS level and birth weight was more pronounced in male infants. Furthermore, a positive association among branched PFOS isomers (1m-PFOS and 3 + 4 + 5m-PFOS) and gestational age was found. No associations could be found among other PFASs in conjunction with gestational age or birth weight. In conclusion, this investigation suggests that higher PFAS concentrations are associated with lower birth weight, and branched PFOS isomers show greater impact on infant birth weight than linear PFOS.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalEnvironment International
Volume102
DOIs
Publication statusPublished - 2017 Jan 1

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serum
isomer
infant
liquid chromatography
mass spectrometry

All Science Journal Classification (ASJC) codes

  • Environmental Science(all)

Cite this

Li, Meng ; Zeng, Xiao Wen ; Qian, Zhengmin (Min) ; Vaughn, Michael George ; Sauvé, Sébastien ; Paul, Gunther ; Lin, Shao ; Lu, Long ; Hu, Li Wen ; Yang, Bo Yi ; Zhou, Yang ; Qin, Xiao Di ; Xu, Shu Li ; Bao, Wen Wen ; Zhang, Ya Zhi ; Yuan, Ping ; Wang, Jia ; Zhang, Chuan ; Tian, Yan Peng ; Nian, Min ; Xiao, Xiang ; Fu, Chuanxi ; Dong, Guang Hui. / Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China : Guangzhou Birth Cohort Study. In: Environment International. 2017 ; Vol. 102. pp. 1-8.
@article{9bf7c6c50b034dcfa9e58f5e966d3d08,
title = "Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study",
abstract = "Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China. High performance liquid chromatography-mass spectrometry was utilized to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) along with other PFAS levels in cord serum samples. Mothers’ and infants’ characteristics were gathered from medical records. The resulting data revealed that higher PFOS, PFOA and isomers of PFOS were associated with lower birth weight. Per ln-unit (ng/mL) increase in cord serum total branched PFOS isomers was associated with a 126.3 g (95{\%} CI: − 195.9, − 56.8) reduction in the weight of infants at birth, while an ln-unit (ng/mL) increase of serum linear PFOS isomers (n-PFOS) was associated with a 57.2 g (95{\%} CI: − 103.1, − 11.3) reduction in the weight of infants at birth upon the subsequent adjustment for potential confounding variables. Notably, the association between cord PFAS level and birth weight was more pronounced in male infants. Furthermore, a positive association among branched PFOS isomers (1m-PFOS and 3 + 4 + 5m-PFOS) and gestational age was found. No associations could be found among other PFASs in conjunction with gestational age or birth weight. In conclusion, this investigation suggests that higher PFAS concentrations are associated with lower birth weight, and branched PFOS isomers show greater impact on infant birth weight than linear PFOS.",
author = "Meng Li and Zeng, {Xiao Wen} and Qian, {Zhengmin (Min)} and Vaughn, {Michael George} and S{\'e}bastien Sauv{\'e} and Gunther Paul and Shao Lin and Long Lu and Hu, {Li Wen} and Yang, {Bo Yi} and Yang Zhou and Qin, {Xiao Di} and Xu, {Shu Li} and Bao, {Wen Wen} and Zhang, {Ya Zhi} and Ping Yuan and Jia Wang and Chuan Zhang and Tian, {Yan Peng} and Min Nian and Xiang Xiao and Chuanxi Fu and Dong, {Guang Hui}",
year = "2017",
month = "1",
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doi = "10.1016/j.envint.2017.03.006",
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Li, M, Zeng, XW, Qian, ZM, Vaughn, MG, Sauvé, S, Paul, G, Lin, S, Lu, L, Hu, LW, Yang, BY, Zhou, Y, Qin, XD, Xu, SL, Bao, WW, Zhang, YZ, Yuan, P, Wang, J, Zhang, C, Tian, YP, Nian, M, Xiao, X, Fu, C & Dong, GH 2017, 'Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China: Guangzhou Birth Cohort Study', Environment International, vol. 102, pp. 1-8. https://doi.org/10.1016/j.envint.2017.03.006

Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China : Guangzhou Birth Cohort Study. / Li, Meng; Zeng, Xiao Wen; Qian, Zhengmin (Min); Vaughn, Michael George; Sauvé, Sébastien; Paul, Gunther; Lin, Shao; Lu, Long; Hu, Li Wen; Yang, Bo Yi; Zhou, Yang; Qin, Xiao Di; Xu, Shu Li; Bao, Wen Wen; Zhang, Ya Zhi; Yuan, Ping; Wang, Jia; Zhang, Chuan; Tian, Yan Peng; Nian, Min; Xiao, Xiang; Fu, Chuanxi; Dong, Guang Hui.

In: Environment International, Vol. 102, 01.01.2017, p. 1-8.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Isomers of perfluorooctanesulfonate (PFOS) in cord serum and birth outcomes in China

T2 - Guangzhou Birth Cohort Study

AU - Li, Meng

AU - Zeng, Xiao Wen

AU - Qian, Zhengmin (Min)

AU - Vaughn, Michael George

AU - Sauvé, Sébastien

AU - Paul, Gunther

AU - Lin, Shao

AU - Lu, Long

AU - Hu, Li Wen

AU - Yang, Bo Yi

AU - Zhou, Yang

AU - Qin, Xiao Di

AU - Xu, Shu Li

AU - Bao, Wen Wen

AU - Zhang, Ya Zhi

AU - Yuan, Ping

AU - Wang, Jia

AU - Zhang, Chuan

AU - Tian, Yan Peng

AU - Nian, Min

AU - Xiao, Xiang

AU - Fu, Chuanxi

AU - Dong, Guang Hui

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China. High performance liquid chromatography-mass spectrometry was utilized to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) along with other PFAS levels in cord serum samples. Mothers’ and infants’ characteristics were gathered from medical records. The resulting data revealed that higher PFOS, PFOA and isomers of PFOS were associated with lower birth weight. Per ln-unit (ng/mL) increase in cord serum total branched PFOS isomers was associated with a 126.3 g (95% CI: − 195.9, − 56.8) reduction in the weight of infants at birth, while an ln-unit (ng/mL) increase of serum linear PFOS isomers (n-PFOS) was associated with a 57.2 g (95% CI: − 103.1, − 11.3) reduction in the weight of infants at birth upon the subsequent adjustment for potential confounding variables. Notably, the association between cord PFAS level and birth weight was more pronounced in male infants. Furthermore, a positive association among branched PFOS isomers (1m-PFOS and 3 + 4 + 5m-PFOS) and gestational age was found. No associations could be found among other PFASs in conjunction with gestational age or birth weight. In conclusion, this investigation suggests that higher PFAS concentrations are associated with lower birth weight, and branched PFOS isomers show greater impact on infant birth weight than linear PFOS.

AB - Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China. High performance liquid chromatography-mass spectrometry was utilized to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) along with other PFAS levels in cord serum samples. Mothers’ and infants’ characteristics were gathered from medical records. The resulting data revealed that higher PFOS, PFOA and isomers of PFOS were associated with lower birth weight. Per ln-unit (ng/mL) increase in cord serum total branched PFOS isomers was associated with a 126.3 g (95% CI: − 195.9, − 56.8) reduction in the weight of infants at birth, while an ln-unit (ng/mL) increase of serum linear PFOS isomers (n-PFOS) was associated with a 57.2 g (95% CI: − 103.1, − 11.3) reduction in the weight of infants at birth upon the subsequent adjustment for potential confounding variables. Notably, the association between cord PFAS level and birth weight was more pronounced in male infants. Furthermore, a positive association among branched PFOS isomers (1m-PFOS and 3 + 4 + 5m-PFOS) and gestational age was found. No associations could be found among other PFASs in conjunction with gestational age or birth weight. In conclusion, this investigation suggests that higher PFAS concentrations are associated with lower birth weight, and branched PFOS isomers show greater impact on infant birth weight than linear PFOS.

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