Isopanduratin a from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans

Jae Kwan Hwang, Jae Youn Chung, Nam In Baek, Jung Hee Park

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

An antibacterial compound active against Streptococcus mutans was isolated from Kaempferia pandurata and identified as isopanduratin A using 1H NMR, 13C NMR and EI-MS. The minimum inhibitory concentration (MIC) of isopanduratin A was 4mg/l which was much lower than that of some other natural anticariogenic agents such as sanguinarine (12mg/l), green tea extract and carvacrol (125mg/l), thymol (250mg/l) and isoeugenol and eucalyptol (500mg/l). The bactericidal test showed that isopanduratin A completely inactivated S. mutans at 20mg/l in 1min. Significant inhibitory activity of isopanduratin A was also observed against S. sobrinus, S. sanguinis and S. salivarius with an MIC of 4mg/l. Damage to the cell membrane and cell wall of S. mutans by isopanduratin A was shown using transmission electron microscopy (TEM). These results suggest that isopanduratin A could be employed as a potential antibacterial agent for preventing dental caries.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume23
Issue number4
DOIs
Publication statusPublished - 2004 Apr 1

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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