Isopanduratin a from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans

Jae Kwan Hwang; Jae Youn Chung; Nam In Baek; Jung Hee Park

doi:10.1016/j.ijantimicag.2003.08.011

Isopanduratin a from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans

Jae Kwan Hwang, Jae Youn Chung, Nam In Baek, Jung Hee Park

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

An antibacterial compound active against Streptococcus mutans was isolated from Kaempferia pandurata and identified as isopanduratin A using ¹H NMR, ¹³C NMR and EI-MS. The minimum inhibitory concentration (MIC) of isopanduratin A was 4mg/l which was much lower than that of some other natural anticariogenic agents such as sanguinarine (12mg/l), green tea extract and carvacrol (125mg/l), thymol (250mg/l) and isoeugenol and eucalyptol (500mg/l). The bactericidal test showed that isopanduratin A completely inactivated S. mutans at 20mg/l in 1min. Significant inhibitory activity of isopanduratin A was also observed against S. sobrinus, S. sanguinis and S. salivarius with an MIC of 4mg/l. Damage to the cell membrane and cell wall of S. mutans by isopanduratin A was shown using transmission electron microscopy (TEM). These results suggest that isopanduratin A could be employed as a potential antibacterial agent for preventing dental caries.

Original language	English
Pages (from-to)	377-381
Number of pages	5
Journal	International Journal of Antimicrobial Agents
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.ijantimicag.2003.08.011
Publication status	Published - 2004 Apr

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University.

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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title = "Isopanduratin a from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans",

abstract = "An antibacterial compound active against Streptococcus mutans was isolated from Kaempferia pandurata and identified as isopanduratin A using 1H NMR, 13C NMR and EI-MS. The minimum inhibitory concentration (MIC) of isopanduratin A was 4mg/l which was much lower than that of some other natural anticariogenic agents such as sanguinarine (12mg/l), green tea extract and carvacrol (125mg/l), thymol (250mg/l) and isoeugenol and eucalyptol (500mg/l). The bactericidal test showed that isopanduratin A completely inactivated S. mutans at 20mg/l in 1min. Significant inhibitory activity of isopanduratin A was also observed against S. sobrinus, S. sanguinis and S. salivarius with an MIC of 4mg/l. Damage to the cell membrane and cell wall of S. mutans by isopanduratin A was shown using transmission electron microscopy (TEM). These results suggest that isopanduratin A could be employed as a potential antibacterial agent for preventing dental caries.",

author = "Hwang, {Jae Kwan} and Chung, {Jae Youn} and Baek, {Nam In} and Park, {Jung Hee}",

note = "Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University.",

year = "2004",

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doi = "10.1016/j.ijantimicag.2003.08.011",

language = "English",

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AU - Hwang, Jae Kwan

AU - Chung, Jae Youn

AU - Baek, Nam In

AU - Park, Jung Hee

N1 - Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University.

PY - 2004/4

Y1 - 2004/4

N2 - An antibacterial compound active against Streptococcus mutans was isolated from Kaempferia pandurata and identified as isopanduratin A using 1H NMR, 13C NMR and EI-MS. The minimum inhibitory concentration (MIC) of isopanduratin A was 4mg/l which was much lower than that of some other natural anticariogenic agents such as sanguinarine (12mg/l), green tea extract and carvacrol (125mg/l), thymol (250mg/l) and isoeugenol and eucalyptol (500mg/l). The bactericidal test showed that isopanduratin A completely inactivated S. mutans at 20mg/l in 1min. Significant inhibitory activity of isopanduratin A was also observed against S. sobrinus, S. sanguinis and S. salivarius with an MIC of 4mg/l. Damage to the cell membrane and cell wall of S. mutans by isopanduratin A was shown using transmission electron microscopy (TEM). These results suggest that isopanduratin A could be employed as a potential antibacterial agent for preventing dental caries.

AB - An antibacterial compound active against Streptococcus mutans was isolated from Kaempferia pandurata and identified as isopanduratin A using 1H NMR, 13C NMR and EI-MS. The minimum inhibitory concentration (MIC) of isopanduratin A was 4mg/l which was much lower than that of some other natural anticariogenic agents such as sanguinarine (12mg/l), green tea extract and carvacrol (125mg/l), thymol (250mg/l) and isoeugenol and eucalyptol (500mg/l). The bactericidal test showed that isopanduratin A completely inactivated S. mutans at 20mg/l in 1min. Significant inhibitory activity of isopanduratin A was also observed against S. sobrinus, S. sanguinis and S. salivarius with an MIC of 4mg/l. Damage to the cell membrane and cell wall of S. mutans by isopanduratin A was shown using transmission electron microscopy (TEM). These results suggest that isopanduratin A could be employed as a potential antibacterial agent for preventing dental caries.

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Isopanduratin a from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans

Abstract

Bibliographical note

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UN SDGs

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