Abstract
An antibacterial compound active against Streptococcus mutans was isolated from Kaempferia pandurata and identified as isopanduratin A using 1H NMR, 13C NMR and EI-MS. The minimum inhibitory concentration (MIC) of isopanduratin A was 4mg/l which was much lower than that of some other natural anticariogenic agents such as sanguinarine (12mg/l), green tea extract and carvacrol (125mg/l), thymol (250mg/l) and isoeugenol and eucalyptol (500mg/l). The bactericidal test showed that isopanduratin A completely inactivated S. mutans at 20mg/l in 1min. Significant inhibitory activity of isopanduratin A was also observed against S. sobrinus, S. sanguinis and S. salivarius with an MIC of 4mg/l. Damage to the cell membrane and cell wall of S. mutans by isopanduratin A was shown using transmission electron microscopy (TEM). These results suggest that isopanduratin A could be employed as a potential antibacterial agent for preventing dental caries.
| Original language | English |
|---|---|
| Pages (from-to) | 377-381 |
| Number of pages | 5 |
| Journal | International Journal of Antimicrobial Agents |
| Volume | 23 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2004 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)
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Isopanduratin a from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans. / Hwang, Jae-Kwan; Chung, Jae Youn; Baek, Nam In; Park, Jung Hee.
In: International Journal of Antimicrobial Agents, Vol. 23, No. 4, 01.04.2004, p. 377-381.Research output: Contribution to journal › Article
TY - JOUR
T1 - Isopanduratin a from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans
AU - Hwang, Jae-Kwan
AU - Chung, Jae Youn
AU - Baek, Nam In
AU - Park, Jung Hee
PY - 2004/4/1
Y1 - 2004/4/1
N2 - An antibacterial compound active against Streptococcus mutans was isolated from Kaempferia pandurata and identified as isopanduratin A using 1H NMR, 13C NMR and EI-MS. The minimum inhibitory concentration (MIC) of isopanduratin A was 4mg/l which was much lower than that of some other natural anticariogenic agents such as sanguinarine (12mg/l), green tea extract and carvacrol (125mg/l), thymol (250mg/l) and isoeugenol and eucalyptol (500mg/l). The bactericidal test showed that isopanduratin A completely inactivated S. mutans at 20mg/l in 1min. Significant inhibitory activity of isopanduratin A was also observed against S. sobrinus, S. sanguinis and S. salivarius with an MIC of 4mg/l. Damage to the cell membrane and cell wall of S. mutans by isopanduratin A was shown using transmission electron microscopy (TEM). These results suggest that isopanduratin A could be employed as a potential antibacterial agent for preventing dental caries.
AB - An antibacterial compound active against Streptococcus mutans was isolated from Kaempferia pandurata and identified as isopanduratin A using 1H NMR, 13C NMR and EI-MS. The minimum inhibitory concentration (MIC) of isopanduratin A was 4mg/l which was much lower than that of some other natural anticariogenic agents such as sanguinarine (12mg/l), green tea extract and carvacrol (125mg/l), thymol (250mg/l) and isoeugenol and eucalyptol (500mg/l). The bactericidal test showed that isopanduratin A completely inactivated S. mutans at 20mg/l in 1min. Significant inhibitory activity of isopanduratin A was also observed against S. sobrinus, S. sanguinis and S. salivarius with an MIC of 4mg/l. Damage to the cell membrane and cell wall of S. mutans by isopanduratin A was shown using transmission electron microscopy (TEM). These results suggest that isopanduratin A could be employed as a potential antibacterial agent for preventing dental caries.
UR - http://www.scopus.com/inward/record.url?scp=1842739114&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842739114&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2003.08.011
DO - 10.1016/j.ijantimicag.2003.08.011
M3 - Article
VL - 23
SP - 377
EP - 381
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 4
ER -