Itraconazole-Laponite: Kinetics and mechanism of drug release

Hyun Jung, Hyun Mi Kim, Young Bin Choy, Seong Ju Hwang, Jin Ho Choy

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalApplied Clay Science
Volume40
Issue number1-4
DOIs
Publication statusPublished - 2008 Jun 1

Fingerprint

Itraconazole
drug
kinetics
Kinetics
Pharmaceutical Preparations
Cations
ion exchange
Ion exchange
Dissolution
cation
dissolution
clay
Water
modeling
laponite
water
effect

All Science Journal Classification (ASJC) codes

  • Geology
  • Geochemistry and Petrology

Cite this

Jung, Hyun ; Kim, Hyun Mi ; Choy, Young Bin ; Hwang, Seong Ju ; Choy, Jin Ho. / Itraconazole-Laponite : Kinetics and mechanism of drug release. In: Applied Clay Science. 2008 ; Vol. 40, No. 1-4. pp. 99-107.
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Itraconazole-Laponite : Kinetics and mechanism of drug release. / Jung, Hyun; Kim, Hyun Mi; Choy, Young Bin; Hwang, Seong Ju; Choy, Jin Ho.

In: Applied Clay Science, Vol. 40, No. 1-4, 01.06.2008, p. 99-107.

Research output: Contribution to journalArticle

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