Jab1 has negative effects on p53-mediated genotoxic stresses

Eun Woo Lee, Sangsik Lee, Jaewhan Song

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this study, we use promoter analysis to show that interaction between Jab1 and p53 induces suppression of p53 activation in U2OS and H1299 cells. Interaction between p53 and Jab1 was further confirmed by immunoprecipitation and immunofluorescent analyses. In particular, Jab1 was able to induce nuclear export of p53 as previously reported. When Jab1 was overexpressed in U2OS cells followed by etoposide or hydrogen peroxide (H2O2), cell death induced by such stresses was protected against. On the contrary, when the level of Jab1 was suppressed in U2OS cells, cytotoxicity imposed by etoposide and H2O2 was dramatically increased, suggesting a cell protective role for Jab1. These results indicate that Jab1 is a negative regulator of p53 and a plausible oncogene.

Original languageEnglish
Pages (from-to)299-303
Number of pages5
JournalBMB reports
Volume42
Issue number5
DOIs
Publication statusPublished - 2009 May

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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