Juvenile Myasthenia Gravis in Korea: Subgroup Analysis According to Sex and Onset Age

Ha Neul Lee, Hoon Chul Kang, Joon Soo Lee, Heung Dong Kim, Ha Young Shin, Seung Min Kim, Il Nam Sunwoo, Young Mock Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Juvenile myasthenia gravis presents before 18 years of age with different characteristics according to racial background and pubertal development. The authors aimed to determine the clinical characteristics of children and adolescents of Korean ethnicity with myasthenia gravis, and evaluate the presentation and clinical outcomes according to the sex and onset age of the patients. The authors recruited 88 Korean juvenile myasthenia gravis patients between September 2005 and August 2015. Worse clinical severity from presentation, more aggressive treatment strategies, and worse final treatment outcomes were noted in girls with postpubertal onset than in the other patients. The symptoms were milder (pure ocular presentation in 96.6% [85/88]) and the disease course was more benign (94.3% [83/88]) in this study than in the literature. The homogenous racial background might have contributed to these results. These findings highlight the influence of pubertal development and the need for timely and appropriate active treatment, including thymectomy, to improve prognosis.

Original languageEnglish
Pages (from-to)1561-1568
Number of pages8
JournalJournal of Child Neurology
Volume31
Issue number14
DOIs
Publication statusPublished - 2016 Dec 1

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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