Ketamine modulates calcium homeostasis in hypoxia-reoxygenated cardiomyocytes

Jang Ho Roh, Woochul Chang, Soyeon Lim, Heesang Song, Byeong Wook Song, Hye Jung Kim, Min Ji Cha, Yangsoo Jang, Nam Sik Chung, Yong Woo Hong, Ki Chul Hwang

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3 Citations (Scopus)

Abstract

Ketamine is clinically used as an inducer of anesthesia in critically ill patients because it has more stable hemodynamics than barbiturates or inhaled anesthetic agent. It has been known the effect of anesthetic related with calcium homeostasis in myocardium but there are few studies for myocardial protection of ketamine from ischemiareperfusion injury. We therefore observed protective effects of ketamine on survival of ischemia-reoxygenated cardiomyocytes in phosphorylation levels of Erk and Akt as well as suppression of pro-apoptotic protens, Bax and cytochrome C, and induction of anti-apoptotic protein, Bcl-2. Ketamine also overcame intracellular Ca2+ overload. We observed significant induction in transcript level of calreticulin, PMCA1, ion channels(L-type Ca2+-channel, Kir3.4, Kir6.1) and suppression in transcript level of calmodulin, and SERCA 2a in ketamine-treated cardiomyocytes. In conclusion, ketamine was protective of cardiomyocytesunder hypoxia-reperfusion condition. Therefore, we have provided new insight into myocardial protection of anesthetic agents so a better understanding of the role of anesthetics in the prevention of myocardial injury may provide strategies to improve outcome.

Original languageEnglish
Pages (from-to)512-520
Number of pages9
JournalTissue Engineering and Regenerative Medicine
Volume5
Issue number3
Publication statusPublished - 2008 Sep

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomedical Engineering

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    Roh, J. H., Chang, W., Lim, S., Song, H., Song, B. W., Kim, H. J., Cha, M. J., Jang, Y., Chung, N. S., Hong, Y. W., & Hwang, K. C. (2008). Ketamine modulates calcium homeostasis in hypoxia-reoxygenated cardiomyocytes. Tissue Engineering and Regenerative Medicine, 5(3), 512-520.