Strategy exercises based on roadmapping approaches are increasingly being used to support effective management and foresight of diverse functions of technological innovation systems. In addition to roadmaps for technology development, a set of specialised roadmaps that particularly focus on the development of other functional activities of innovation (such as standardisation, education and workforce development, and infrastructure development) are being developed for their timely and effective management in support of innovation. As there are significant relationships and interdependences between these various functions, there may be value in systematic integration and alignment of corresponding roadmaps, in order to promote the overall functioning of technological innovation systems. However, evidence shows that they are largely disconnected from each other, increasing potential risks of inefficient use of resources and missed opportunities to capture greater value from technology RD. In this context, this paper presents case study analyses of recent roadmapping exercises, demonstrating the importance of aligning multiple, interrelated roadmaps focusing on various functions of innovation systems in a coherent and integrated way; it also identifies key guiding principles and practical requirements to support such integration and alignment. Roadmaps developed by Manufacturing USA institutes provide interesting case studies, as they have broad innovation missions including, for example, both technology development as well as education and workforce development. By identifying associated challenges as well as useful activities adopted in practice, the paper offers guidance on how integrated roadmapping processes can be designed for more effective management of diverse functional activities of technological innovation systems. It thus provides an initial stepping stone for developing a more structured process of innovation system foresight, which is increasingly important with the systemic, contextual and evolutionary understanding of innovation.