Kinetically controlled ligation for the convergent chemical synthesis of proteins

Duhee Bang, Brad L. Pentelute, Stephen B.H. Kent

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

(Figure Presented) Converging on the goal: New chemistry enables the key Cys-peptide-(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.

Original languageEnglish
Pages (from-to)3985-3988
Number of pages4
JournalAngewandte Chemie - International Edition
Volume45
Issue number24
DOIs
Publication statusPublished - 2006 Jun 12

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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