Kinetically controlled ligation for the convergent chemical synthesis of proteins

Duhee Bang, Brad L. Pentelute, Stephen B.H. Kent

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

(Figure Presented) Converging on the goal: New chemistry enables the key Cys-peptide-(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.

Original languageEnglish
Pages (from-to)3985-3988
Number of pages4
JournalAngewandte Chemie - International Edition
Volume45
Issue number24
DOIs
Publication statusPublished - 2006 Jun 12

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Peptides
Proteins

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Bang, Duhee ; Pentelute, Brad L. ; Kent, Stephen B.H. / Kinetically controlled ligation for the convergent chemical synthesis of proteins. In: Angewandte Chemie - International Edition. 2006 ; Vol. 45, No. 24. pp. 3985-3988.
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Kinetically controlled ligation for the convergent chemical synthesis of proteins. / Bang, Duhee; Pentelute, Brad L.; Kent, Stephen B.H.

In: Angewandte Chemie - International Edition, Vol. 45, No. 24, 12.06.2006, p. 3985-3988.

Research output: Contribution to journalArticle

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