KNOW-CKD (KoreaN cohort study for Outcome in patients with Chronic Kidney Disease): Design and methods

Kook Hwan Oh, Sue Kyung Park, Hayne Cho Park, Ho Jun Chin, Dong Wan Chae, Kyu Hun Choi, SeungHyeok Han, TaeHyun Yoo, Kyubeck Lee, Yong Soo Kim, Wookyung Chung, Young Hwan Hwang, Soo Wan Kim, Yeong Hoon Kim, Sun Woo Kang, Byung Joo Park, Joongyub Lee, Curie Ahn

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: The progression and complications of chronic kidney disease should differ depending on the cause (C), glomerular filtration rate category (G), and albuminuria (A). The KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease), which is a prospective cohort study, enrolls subjects with chronic kidney disease stages 1 to 5 (predialysis). Methods/Design. Nine nephrology centers in major university hospitals throughout Korea will enroll approximately 2,450 adults with chronic kidney disease over a 5-year period from 2011 to 2015. The participating individuals will be monitored for approximately 10 years until death or until end-stage renal disease occurs. The subjects will be classified into subgroups based on the following specific causes of chronic kidney disease: glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, polycystic kidney disease, and others. The eligible subjects will be evaluated at baseline for socio-demographic information, detailed personal/family history, office BP, quality of life, and health behaviors. After enrollment in the study, thorough assessments, including laboratory tests, cardiac evaluation and radiologic imaging, will be performed according to the standardized protocol. The biospecimen samples will be collected regularly. A renal event is defined by >50% decrease in estimated GFR (eGFR) from the baseline values, doubling of serum creatinine, or end-stage renal disease. The primary composite outcome consists of renal events, cardiovascular events, and death. As of September 2013, 1,470 adult chronic kidney disease subjects were enrolled in the study, including 543 subjects with glomerulonephritis, 317 with diabetic nephropathy, 294 with hypertensive nephropathy and 249 with polycystic kidney disease. Discussion. As the first large-scale chronic kidney disease cohort study to be established and maintained longitudinally for up to 10 years, the KNOW-CKD will help to clarify the natural course, complication profiles, and risk factors of Asian populations with chronic kidney disease. Trial registration. No. NCT01630486 at.

Original languageEnglish
Article number80
JournalBMC Nephrology
Volume15
Issue number1
DOIs
Publication statusPublished - 2014 May 19

Fingerprint

Chronic Renal Insufficiency
Cohort Studies
Polycystic Kidney Diseases
Diabetic Nephropathies
Glomerulonephritis
Chronic Kidney Failure
Kidney
Albuminuria
Nephrology
Health Behavior
Korea
Glomerular Filtration Rate
Creatinine
Quality of Life
Demography
Prospective Studies
Serum
Population

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Oh, K. H., Park, S. K., Park, H. C., Chin, H. J., Chae, D. W., Choi, K. H., ... Ahn, C. (2014). KNOW-CKD (KoreaN cohort study for Outcome in patients with Chronic Kidney Disease): Design and methods. BMC Nephrology, 15(1), [80]. https://doi.org/10.1186/1471-2369-15-80
Oh, Kook Hwan ; Park, Sue Kyung ; Park, Hayne Cho ; Chin, Ho Jun ; Chae, Dong Wan ; Choi, Kyu Hun ; Han, SeungHyeok ; Yoo, TaeHyun ; Lee, Kyubeck ; Kim, Yong Soo ; Chung, Wookyung ; Hwang, Young Hwan ; Kim, Soo Wan ; Kim, Yeong Hoon ; Kang, Sun Woo ; Park, Byung Joo ; Lee, Joongyub ; Ahn, Curie. / KNOW-CKD (KoreaN cohort study for Outcome in patients with Chronic Kidney Disease) : Design and methods. In: BMC Nephrology. 2014 ; Vol. 15, No. 1.
@article{403dca5ac2824184acbfb83b6c1645d0,
title = "KNOW-CKD (KoreaN cohort study for Outcome in patients with Chronic Kidney Disease): Design and methods",
abstract = "Background: The progression and complications of chronic kidney disease should differ depending on the cause (C), glomerular filtration rate category (G), and albuminuria (A). The KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease), which is a prospective cohort study, enrolls subjects with chronic kidney disease stages 1 to 5 (predialysis). Methods/Design. Nine nephrology centers in major university hospitals throughout Korea will enroll approximately 2,450 adults with chronic kidney disease over a 5-year period from 2011 to 2015. The participating individuals will be monitored for approximately 10 years until death or until end-stage renal disease occurs. The subjects will be classified into subgroups based on the following specific causes of chronic kidney disease: glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, polycystic kidney disease, and others. The eligible subjects will be evaluated at baseline for socio-demographic information, detailed personal/family history, office BP, quality of life, and health behaviors. After enrollment in the study, thorough assessments, including laboratory tests, cardiac evaluation and radiologic imaging, will be performed according to the standardized protocol. The biospecimen samples will be collected regularly. A renal event is defined by >50{\%} decrease in estimated GFR (eGFR) from the baseline values, doubling of serum creatinine, or end-stage renal disease. The primary composite outcome consists of renal events, cardiovascular events, and death. As of September 2013, 1,470 adult chronic kidney disease subjects were enrolled in the study, including 543 subjects with glomerulonephritis, 317 with diabetic nephropathy, 294 with hypertensive nephropathy and 249 with polycystic kidney disease. Discussion. As the first large-scale chronic kidney disease cohort study to be established and maintained longitudinally for up to 10 years, the KNOW-CKD will help to clarify the natural course, complication profiles, and risk factors of Asian populations with chronic kidney disease. Trial registration. No. NCT01630486 at.",
author = "Oh, {Kook Hwan} and Park, {Sue Kyung} and Park, {Hayne Cho} and Chin, {Ho Jun} and Chae, {Dong Wan} and Choi, {Kyu Hun} and SeungHyeok Han and TaeHyun Yoo and Kyubeck Lee and Kim, {Yong Soo} and Wookyung Chung and Hwang, {Young Hwan} and Kim, {Soo Wan} and Kim, {Yeong Hoon} and Kang, {Sun Woo} and Park, {Byung Joo} and Joongyub Lee and Curie Ahn",
year = "2014",
month = "5",
day = "19",
doi = "10.1186/1471-2369-15-80",
language = "English",
volume = "15",
journal = "BMC Nephrology",
issn = "1471-2369",
publisher = "BioMed Central",
number = "1",

}

Oh, KH, Park, SK, Park, HC, Chin, HJ, Chae, DW, Choi, KH, Han, S, Yoo, T, Lee, K, Kim, YS, Chung, W, Hwang, YH, Kim, SW, Kim, YH, Kang, SW, Park, BJ, Lee, J & Ahn, C 2014, 'KNOW-CKD (KoreaN cohort study for Outcome in patients with Chronic Kidney Disease): Design and methods', BMC Nephrology, vol. 15, no. 1, 80. https://doi.org/10.1186/1471-2369-15-80

KNOW-CKD (KoreaN cohort study for Outcome in patients with Chronic Kidney Disease) : Design and methods. / Oh, Kook Hwan; Park, Sue Kyung; Park, Hayne Cho; Chin, Ho Jun; Chae, Dong Wan; Choi, Kyu Hun; Han, SeungHyeok; Yoo, TaeHyun; Lee, Kyubeck; Kim, Yong Soo; Chung, Wookyung; Hwang, Young Hwan; Kim, Soo Wan; Kim, Yeong Hoon; Kang, Sun Woo; Park, Byung Joo; Lee, Joongyub; Ahn, Curie.

In: BMC Nephrology, Vol. 15, No. 1, 80, 19.05.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - KNOW-CKD (KoreaN cohort study for Outcome in patients with Chronic Kidney Disease)

T2 - Design and methods

AU - Oh, Kook Hwan

AU - Park, Sue Kyung

AU - Park, Hayne Cho

AU - Chin, Ho Jun

AU - Chae, Dong Wan

AU - Choi, Kyu Hun

AU - Han, SeungHyeok

AU - Yoo, TaeHyun

AU - Lee, Kyubeck

AU - Kim, Yong Soo

AU - Chung, Wookyung

AU - Hwang, Young Hwan

AU - Kim, Soo Wan

AU - Kim, Yeong Hoon

AU - Kang, Sun Woo

AU - Park, Byung Joo

AU - Lee, Joongyub

AU - Ahn, Curie

PY - 2014/5/19

Y1 - 2014/5/19

N2 - Background: The progression and complications of chronic kidney disease should differ depending on the cause (C), glomerular filtration rate category (G), and albuminuria (A). The KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease), which is a prospective cohort study, enrolls subjects with chronic kidney disease stages 1 to 5 (predialysis). Methods/Design. Nine nephrology centers in major university hospitals throughout Korea will enroll approximately 2,450 adults with chronic kidney disease over a 5-year period from 2011 to 2015. The participating individuals will be monitored for approximately 10 years until death or until end-stage renal disease occurs. The subjects will be classified into subgroups based on the following specific causes of chronic kidney disease: glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, polycystic kidney disease, and others. The eligible subjects will be evaluated at baseline for socio-demographic information, detailed personal/family history, office BP, quality of life, and health behaviors. After enrollment in the study, thorough assessments, including laboratory tests, cardiac evaluation and radiologic imaging, will be performed according to the standardized protocol. The biospecimen samples will be collected regularly. A renal event is defined by >50% decrease in estimated GFR (eGFR) from the baseline values, doubling of serum creatinine, or end-stage renal disease. The primary composite outcome consists of renal events, cardiovascular events, and death. As of September 2013, 1,470 adult chronic kidney disease subjects were enrolled in the study, including 543 subjects with glomerulonephritis, 317 with diabetic nephropathy, 294 with hypertensive nephropathy and 249 with polycystic kidney disease. Discussion. As the first large-scale chronic kidney disease cohort study to be established and maintained longitudinally for up to 10 years, the KNOW-CKD will help to clarify the natural course, complication profiles, and risk factors of Asian populations with chronic kidney disease. Trial registration. No. NCT01630486 at.

AB - Background: The progression and complications of chronic kidney disease should differ depending on the cause (C), glomerular filtration rate category (G), and albuminuria (A). The KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease), which is a prospective cohort study, enrolls subjects with chronic kidney disease stages 1 to 5 (predialysis). Methods/Design. Nine nephrology centers in major university hospitals throughout Korea will enroll approximately 2,450 adults with chronic kidney disease over a 5-year period from 2011 to 2015. The participating individuals will be monitored for approximately 10 years until death or until end-stage renal disease occurs. The subjects will be classified into subgroups based on the following specific causes of chronic kidney disease: glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, polycystic kidney disease, and others. The eligible subjects will be evaluated at baseline for socio-demographic information, detailed personal/family history, office BP, quality of life, and health behaviors. After enrollment in the study, thorough assessments, including laboratory tests, cardiac evaluation and radiologic imaging, will be performed according to the standardized protocol. The biospecimen samples will be collected regularly. A renal event is defined by >50% decrease in estimated GFR (eGFR) from the baseline values, doubling of serum creatinine, or end-stage renal disease. The primary composite outcome consists of renal events, cardiovascular events, and death. As of September 2013, 1,470 adult chronic kidney disease subjects were enrolled in the study, including 543 subjects with glomerulonephritis, 317 with diabetic nephropathy, 294 with hypertensive nephropathy and 249 with polycystic kidney disease. Discussion. As the first large-scale chronic kidney disease cohort study to be established and maintained longitudinally for up to 10 years, the KNOW-CKD will help to clarify the natural course, complication profiles, and risk factors of Asian populations with chronic kidney disease. Trial registration. No. NCT01630486 at.

UR - http://www.scopus.com/inward/record.url?scp=84902382706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902382706&partnerID=8YFLogxK

U2 - 10.1186/1471-2369-15-80

DO - 10.1186/1471-2369-15-80

M3 - Article

C2 - 24884708

AN - SCOPUS:84902382706

VL - 15

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

IS - 1

M1 - 80

ER -