Kojyl cinnamate ester derivatives promote adiponectin production during adipogenesis in human adipose tissue-derived mesenchymal stem cells

Ho Sik Rho, Soo Hyun Hong, Jongho Park, Hyo Il Jung, Young Ho Park, John Hwan Lee, Song Seok Shin, Minsoo Noh

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The subcutaneous fat tissue mass gradually decreases with age, and its regulation is a strategy to develop anti-aging compounds to ameliorate the photo-aging of human skin. The adipogenesis of human adipose tissue-mesenchymal stem cells (hAT-MSCs) can be used as a model to discover novel anti-aging compounds. Cinnamomum cassia methanol extracts were identified as adipogenesis-promoting agents by natural product library screening. Cinnamates, the major chemical components of Cinnamomum cassia extracts, promoted adipogenesis in hAT-MSCs. We synthesized kojyl cinnamate ester derivatives to improve the pharmacological activity of cinnamates. Structure-activity studies of kojyl cinnamate derivatives showed that both the α,β-unsaturated carbonyl ester group and the kojic acid moiety play core roles in promoting adiponectin production during adipogenesis in hAT-MSCs. We conclude that kojyl cinnamate ester derivatives provide novel pharmacophores that can regulate adipogenesis in hAT-MSCs.

Original languageEnglish
Pages (from-to)2141-2145
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number9
DOIs
Publication statusPublished - 2014 May 1

Bibliographical note

Funding Information:
This research was supported by and the National Research Foundation of Korea (NRF) Grant funded by the Ministry of Education, Science and Technology (Grant No. 2012012738 ).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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