Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success

Eue Keun Choi, Jae Hyung Park, Ji Young Lee, Chung Mo Nam, Min Ki Hwang, Jae Sun Uhm, Boyoung Joung, Young Guk Ko, Moon Hyoung Lee, Steven A. Lubitz, Patrick T. Ellinor, Hui Nam Pak

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

BACKGROUND: Genomewide association studies have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between top susceptibility loci and AF recurrence after ablation have not been examined in Asian populations. We examined whether the top single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (PITX2), 16q22 (ZFHX3), and 1q21 (KCNN3) were associated with AF in a Korean population and whether these SNPs were associated with clinical outcomes after catheter ablation for AF.

METHODS AND RESULTS: We determined the association between 4 SNPs and AF in 1068 AF patients who underwent catheter ablation (74.6% male, aged 57.5±10.9 years, 67.9% paroxysmal AF) and 1068 age- and sex-matched controls. The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085). Among those patients who underwent catheter ablation for AF, none of the top AF-associated SNPs were associated with long-term clinical recurrence of AF after catheter ablation.

CONCLUSIONS: SNPs at the PITX2 and ZFHX3 loci were strongly associated with AF in Korean patients. In contrast to prior reports, none of the 4 top AF-susceptibility SNPs predicted clinical recurrence after catheter ablation.

Original languageEnglish
Pages (from-to)e002046
JournalJournal of the American Heart Association
Volume4
Issue number8
DOIs
Publication statusPublished - 2015 Aug 13

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Atrial Fibrillation
Catheter Ablation
Single Nucleotide Polymorphism
Odds Ratio
Recurrence
Population
Chromosomes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Choi, Eue Keun ; Park, Jae Hyung ; Lee, Ji Young ; Nam, Chung Mo ; Hwang, Min Ki ; Uhm, Jae Sun ; Joung, Boyoung ; Ko, Young Guk ; Lee, Moon Hyoung ; Lubitz, Steven A. ; Ellinor, Patrick T. ; Pak, Hui Nam. / Korean Atrial Fibrillation (AF) Network : Genetic Variants for AF Do Not Predict Ablation Success. In: Journal of the American Heart Association. 2015 ; Vol. 4, No. 8. pp. e002046.
@article{96f4eb0fa5e84a878b8e9fcb3eaaaae4,
title = "Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success",
abstract = "BACKGROUND: Genomewide association studies have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between top susceptibility loci and AF recurrence after ablation have not been examined in Asian populations. We examined whether the top single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (PITX2), 16q22 (ZFHX3), and 1q21 (KCNN3) were associated with AF in a Korean population and whether these SNPs were associated with clinical outcomes after catheter ablation for AF.METHODS AND RESULTS: We determined the association between 4 SNPs and AF in 1068 AF patients who underwent catheter ablation (74.6{\%} male, aged 57.5±10.9 years, 67.9{\%} paroxysmal AF) and 1068 age- and sex-matched controls. The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95{\%} CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95{\%} CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95{\%} CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95{\%} CI 0.93 to 3.25, P=0.085). Among those patients who underwent catheter ablation for AF, none of the top AF-associated SNPs were associated with long-term clinical recurrence of AF after catheter ablation.CONCLUSIONS: SNPs at the PITX2 and ZFHX3 loci were strongly associated with AF in Korean patients. In contrast to prior reports, none of the 4 top AF-susceptibility SNPs predicted clinical recurrence after catheter ablation.",
author = "Choi, {Eue Keun} and Park, {Jae Hyung} and Lee, {Ji Young} and Nam, {Chung Mo} and Hwang, {Min Ki} and Uhm, {Jae Sun} and Boyoung Joung and Ko, {Young Guk} and Lee, {Moon Hyoung} and Lubitz, {Steven A.} and Ellinor, {Patrick T.} and Pak, {Hui Nam}",
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doi = "10.1161/JAHA.115.002046",
language = "English",
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journal = "Journal of the American Heart Association",
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Choi, EK, Park, JH, Lee, JY, Nam, CM, Hwang, MK, Uhm, JS, Joung, B, Ko, YG, Lee, MH, Lubitz, SA, Ellinor, PT & Pak, HN 2015, 'Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success', Journal of the American Heart Association, vol. 4, no. 8, pp. e002046. https://doi.org/10.1161/JAHA.115.002046

Korean Atrial Fibrillation (AF) Network : Genetic Variants for AF Do Not Predict Ablation Success. / Choi, Eue Keun; Park, Jae Hyung; Lee, Ji Young; Nam, Chung Mo; Hwang, Min Ki; Uhm, Jae Sun; Joung, Boyoung; Ko, Young Guk; Lee, Moon Hyoung; Lubitz, Steven A.; Ellinor, Patrick T.; Pak, Hui Nam.

In: Journal of the American Heart Association, Vol. 4, No. 8, 13.08.2015, p. e002046.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Korean Atrial Fibrillation (AF) Network

T2 - Genetic Variants for AF Do Not Predict Ablation Success

AU - Choi, Eue Keun

AU - Park, Jae Hyung

AU - Lee, Ji Young

AU - Nam, Chung Mo

AU - Hwang, Min Ki

AU - Uhm, Jae Sun

AU - Joung, Boyoung

AU - Ko, Young Guk

AU - Lee, Moon Hyoung

AU - Lubitz, Steven A.

AU - Ellinor, Patrick T.

AU - Pak, Hui Nam

PY - 2015/8/13

Y1 - 2015/8/13

N2 - BACKGROUND: Genomewide association studies have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between top susceptibility loci and AF recurrence after ablation have not been examined in Asian populations. We examined whether the top single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (PITX2), 16q22 (ZFHX3), and 1q21 (KCNN3) were associated with AF in a Korean population and whether these SNPs were associated with clinical outcomes after catheter ablation for AF.METHODS AND RESULTS: We determined the association between 4 SNPs and AF in 1068 AF patients who underwent catheter ablation (74.6% male, aged 57.5±10.9 years, 67.9% paroxysmal AF) and 1068 age- and sex-matched controls. The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085). Among those patients who underwent catheter ablation for AF, none of the top AF-associated SNPs were associated with long-term clinical recurrence of AF after catheter ablation.CONCLUSIONS: SNPs at the PITX2 and ZFHX3 loci were strongly associated with AF in Korean patients. In contrast to prior reports, none of the 4 top AF-susceptibility SNPs predicted clinical recurrence after catheter ablation.

AB - BACKGROUND: Genomewide association studies have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between top susceptibility loci and AF recurrence after ablation have not been examined in Asian populations. We examined whether the top single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (PITX2), 16q22 (ZFHX3), and 1q21 (KCNN3) were associated with AF in a Korean population and whether these SNPs were associated with clinical outcomes after catheter ablation for AF.METHODS AND RESULTS: We determined the association between 4 SNPs and AF in 1068 AF patients who underwent catheter ablation (74.6% male, aged 57.5±10.9 years, 67.9% paroxysmal AF) and 1068 age- and sex-matched controls. The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085). Among those patients who underwent catheter ablation for AF, none of the top AF-associated SNPs were associated with long-term clinical recurrence of AF after catheter ablation.CONCLUSIONS: SNPs at the PITX2 and ZFHX3 loci were strongly associated with AF in Korean patients. In contrast to prior reports, none of the 4 top AF-susceptibility SNPs predicted clinical recurrence after catheter ablation.

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DO - 10.1161/JAHA.115.002046

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