Krypton-enhanced ventilation CT with dual energy technique: Experimental study for optimal krypton concentration

Yong Eun Chung, Sae Rom Hong, Mi Jung Lee, Myungsu Lee, Hye Jeong Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose/Aim of the study. To assess the feasibility of krypton-enhanced ventilation CT using dual energy (DE) technique for various krypton concentrations and to determine the appropriate krypton concentration for DE ventilation CT through an animal study. Materials and Methods. Baseline DECT was first performed on seven New Zealand white rabbits. The animals were then ventilated using 20%, 30%, 40%, 50%, 60%, to 70% krypton concentration, and DECT was performed for each concentration. Krypton extraction was performed through a workstation, and results were displayed on a color map. Overlay Hounsfield unit (HU) values were obtained by two observers in consensus readings. A linear mixed model was used to correlate overlay HU values and krypton concentrations. Visual assessments of the homogeneity of krypton maps were also performed. Results. Mean overlay HU values according to krypton concentration were as follows; 20% krypton, 1.68 ± 5.15; 30% krypton, 3.73 ± 5.93; 40% krypton, 6.92 ± 5.51; 50% krypton, 10.88 ± 5.17; 60% krypton, 14.54 ± 4.23; and 70% krypton, 18.79 ± 3.63. We observed a significant correlation between overlay HU values on krypton maps and krypton concentrations (P < .001). For the krypton color maps, all observers determined universal enhancement on the 70% krypton map for all animals. Conclusion. It is feasible to evaluate lung ventilation function using DECT with a krypton concentration of at least 70%.

Original languageEnglish
Pages (from-to)439-446
Number of pages8
JournalExperimental Lung Research
Volume40
Issue number9
DOIs
Publication statusPublished - 2014 Nov 1

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Krypton
Ventilation
Cordless telephones
Animals
Color

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Medicine(all)

Cite this

Chung, Yong Eun ; Hong, Sae Rom ; Lee, Mi Jung ; Lee, Myungsu ; Lee, Hye Jeong. / Krypton-enhanced ventilation CT with dual energy technique : Experimental study for optimal krypton concentration. In: Experimental Lung Research. 2014 ; Vol. 40, No. 9. pp. 439-446.
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abstract = "Purpose/Aim of the study. To assess the feasibility of krypton-enhanced ventilation CT using dual energy (DE) technique for various krypton concentrations and to determine the appropriate krypton concentration for DE ventilation CT through an animal study. Materials and Methods. Baseline DECT was first performed on seven New Zealand white rabbits. The animals were then ventilated using 20{\%}, 30{\%}, 40{\%}, 50{\%}, 60{\%}, to 70{\%} krypton concentration, and DECT was performed for each concentration. Krypton extraction was performed through a workstation, and results were displayed on a color map. Overlay Hounsfield unit (HU) values were obtained by two observers in consensus readings. A linear mixed model was used to correlate overlay HU values and krypton concentrations. Visual assessments of the homogeneity of krypton maps were also performed. Results. Mean overlay HU values according to krypton concentration were as follows; 20{\%} krypton, 1.68 ± 5.15; 30{\%} krypton, 3.73 ± 5.93; 40{\%} krypton, 6.92 ± 5.51; 50{\%} krypton, 10.88 ± 5.17; 60{\%} krypton, 14.54 ± 4.23; and 70{\%} krypton, 18.79 ± 3.63. We observed a significant correlation between overlay HU values on krypton maps and krypton concentrations (P < .001). For the krypton color maps, all observers determined universal enhancement on the 70{\%} krypton map for all animals. Conclusion. It is feasible to evaluate lung ventilation function using DECT with a krypton concentration of at least 70{\%}.",
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Krypton-enhanced ventilation CT with dual energy technique : Experimental study for optimal krypton concentration. / Chung, Yong Eun; Hong, Sae Rom; Lee, Mi Jung; Lee, Myungsu; Lee, Hye Jeong.

In: Experimental Lung Research, Vol. 40, No. 9, 01.11.2014, p. 439-446.

Research output: Contribution to journalArticle

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AU - Chung, Yong Eun

AU - Hong, Sae Rom

AU - Lee, Mi Jung

AU - Lee, Myungsu

AU - Lee, Hye Jeong

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N2 - Purpose/Aim of the study. To assess the feasibility of krypton-enhanced ventilation CT using dual energy (DE) technique for various krypton concentrations and to determine the appropriate krypton concentration for DE ventilation CT through an animal study. Materials and Methods. Baseline DECT was first performed on seven New Zealand white rabbits. The animals were then ventilated using 20%, 30%, 40%, 50%, 60%, to 70% krypton concentration, and DECT was performed for each concentration. Krypton extraction was performed through a workstation, and results were displayed on a color map. Overlay Hounsfield unit (HU) values were obtained by two observers in consensus readings. A linear mixed model was used to correlate overlay HU values and krypton concentrations. Visual assessments of the homogeneity of krypton maps were also performed. Results. Mean overlay HU values according to krypton concentration were as follows; 20% krypton, 1.68 ± 5.15; 30% krypton, 3.73 ± 5.93; 40% krypton, 6.92 ± 5.51; 50% krypton, 10.88 ± 5.17; 60% krypton, 14.54 ± 4.23; and 70% krypton, 18.79 ± 3.63. We observed a significant correlation between overlay HU values on krypton maps and krypton concentrations (P < .001). For the krypton color maps, all observers determined universal enhancement on the 70% krypton map for all animals. Conclusion. It is feasible to evaluate lung ventilation function using DECT with a krypton concentration of at least 70%.

AB - Purpose/Aim of the study. To assess the feasibility of krypton-enhanced ventilation CT using dual energy (DE) technique for various krypton concentrations and to determine the appropriate krypton concentration for DE ventilation CT through an animal study. Materials and Methods. Baseline DECT was first performed on seven New Zealand white rabbits. The animals were then ventilated using 20%, 30%, 40%, 50%, 60%, to 70% krypton concentration, and DECT was performed for each concentration. Krypton extraction was performed through a workstation, and results were displayed on a color map. Overlay Hounsfield unit (HU) values were obtained by two observers in consensus readings. A linear mixed model was used to correlate overlay HU values and krypton concentrations. Visual assessments of the homogeneity of krypton maps were also performed. Results. Mean overlay HU values according to krypton concentration were as follows; 20% krypton, 1.68 ± 5.15; 30% krypton, 3.73 ± 5.93; 40% krypton, 6.92 ± 5.51; 50% krypton, 10.88 ± 5.17; 60% krypton, 14.54 ± 4.23; and 70% krypton, 18.79 ± 3.63. We observed a significant correlation between overlay HU values on krypton maps and krypton concentrations (P < .001). For the krypton color maps, all observers determined universal enhancement on the 70% krypton map for all animals. Conclusion. It is feasible to evaluate lung ventilation function using DECT with a krypton concentration of at least 70%.

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