Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens

K. M. Park; J. S. You; H. Y. Lee; N. I. Baek; J. K. Hwang

doi:10.1016/S0378-8741(02)00318-5

Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens

K. M. Park, J. S. You, H. Y. Lee, N. I. Baek, J. K. Hwang

Research output: Contribution to journal › Article › peer-review

148 Citations (Scopus)

Abstract

Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by ¹³C-NMR, ¹H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	Journal of Ethnopharmacology
Volume	84
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-8741(02)00318-5
Publication status	Published - 2003 Feb

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University.

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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title = "Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens",

abstract = "Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.",

author = "Park, {K. M.} and You, {J. S.} and Lee, {H. Y.} and Baek, {N. I.} and Hwang, {J. K.}",

note = "Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University.",

year = "2003",

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doi = "10.1016/S0378-8741(02)00318-5",

language = "English",

volume = "84",

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journal = "Journal of Ethnopharmacology",

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T2 - An antibacterial agent from the root bark of Morus alba against oral pathogens

AU - Park, K. M.

AU - You, J. S.

AU - Lee, H. Y.

AU - Baek, N. I.

AU - Hwang, J. K.

N1 - Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University.

PY - 2003/2

Y1 - 2003/2

N2 - Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

AB - Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

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JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 2-3

ER -

Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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