Kuwanon G

An antibacterial agent from the root bark of Morus alba against oral pathogens

K. M. Park, J. S. You, H. Y. Lee, N. I. Baek, Jae-Kwan Hwang

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalJournal of Ethnopharmacology
Volume84
Issue number2-3
DOIs
Publication statusPublished - 2003 Feb 1

Fingerprint

Morus
Anti-Bacterial Agents
Streptococcus mutans
Microbial Sensitivity Tests
Streptococcus sobrinus
Streptococcus sanguis
Gastrin-Secreting Cells
Periodontitis
Dental Caries
Transmission Electron Microscopy
Cell Wall
Methanol
kuwanon G
Cytoplasm
Cell Count
Bacteria
Growth

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Park, K. M. ; You, J. S. ; Lee, H. Y. ; Baek, N. I. ; Hwang, Jae-Kwan. / Kuwanon G : An antibacterial agent from the root bark of Morus alba against oral pathogens. In: Journal of Ethnopharmacology. 2003 ; Vol. 84, No. 2-3. pp. 181-185.
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abstract = "Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.",
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Kuwanon G : An antibacterial agent from the root bark of Morus alba against oral pathogens. / Park, K. M.; You, J. S.; Lee, H. Y.; Baek, N. I.; Hwang, Jae-Kwan.

In: Journal of Ethnopharmacology, Vol. 84, No. 2-3, 01.02.2003, p. 181-185.

Research output: Contribution to journalArticle

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T2 - An antibacterial agent from the root bark of Morus alba against oral pathogens

AU - Park, K. M.

AU - You, J. S.

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AU - Hwang, Jae-Kwan

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