Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens

K. M. Park; J. S. You; H. Y. Lee; N. I. Baek; J. K. Hwang

doi:10.1016/S0378-8741(02)00318-5

Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens

K. M. Park, J. S. You, H. Y. Lee, N. I. Baek, J. K. Hwang

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111 Citations (Scopus)

Abstract

Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by ¹³C-NMR, ¹H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	Journal of Ethnopharmacology
Volume	84
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-8741(02)00318-5
Publication status	Published - 2003 Feb 1

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All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

Cite this

Park, K. M., You, J. S., Lee, H. Y., Baek, N. I., & Hwang, J. K. (2003). Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens. Journal of Ethnopharmacology, 84(2-3), 181-185. https://doi.org/10.1016/S0378-8741(02)00318-5

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abstract = "Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.",

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T2 - An antibacterial agent from the root bark of Morus alba against oral pathogens

AU - Park, K. M.

AU - You, J. S.

AU - Lee, H. Y.

AU - Baek, N. I.

AU - Hwang, J. K.

PY - 2003/2/1

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N2 - Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

AB - Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

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10.1016/S0378-8741(02)00318-5