Abstract
Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.
Original language | English |
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Pages (from-to) | 181-185 |
Number of pages | 5 |
Journal | Journal of Ethnopharmacology |
Volume | 84 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - 2003 Feb |
Bibliographical note
Funding Information:This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University.
All Science Journal Classification (ASJC) codes
- Pharmacology
- Drug Discovery