Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens

K. M. Park, J. S. You, H. Y. Lee, N. I. Baek, J. K. Hwang

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalJournal of Ethnopharmacology
Volume84
Issue number2-3
DOIs
Publication statusPublished - 2003 Feb 1

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this