Abstract
Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.
| Original language | English |
|---|---|
| Pages (from-to) | 181-185 |
| Number of pages | 5 |
| Journal | Journal of Ethnopharmacology |
| Volume | 84 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 2003 Feb 1 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Drug Discovery
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Kuwanon G : An antibacterial agent from the root bark of Morus alba against oral pathogens. / Park, K. M.; You, J. S.; Lee, H. Y.; Baek, N. I.; Hwang, J. K.
In: Journal of Ethnopharmacology, Vol. 84, No. 2-3, 01.02.2003, p. 181-185.Research output: Contribution to journal › Article
TY - JOUR
T1 - Kuwanon G
T2 - An antibacterial agent from the root bark of Morus alba against oral pathogens
AU - Park, K. M.
AU - You, J. S.
AU - Lee, H. Y.
AU - Baek, N. I.
AU - Hwang, J. K.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.
AB - Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.
UR - http://www.scopus.com/inward/record.url?scp=0037297779&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037297779&partnerID=8YFLogxK
U2 - 10.1016/S0378-8741(02)00318-5
DO - 10.1016/S0378-8741(02)00318-5
M3 - Article
C2 - 12648813
AN - SCOPUS:0037297779
VL - 84
SP - 181
EP - 185
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
SN - 0378-8741
IS - 2-3
ER -