Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens

K. M. Park; J. S. You; H. Y. Lee; N. I. Baek; J. K. Hwang

doi:10.1016/S0378-8741(02)00318-5

Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens

K. M. Park, J. S. You, H. Y. Lee, N. I. Baek, J. K. Hwang

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Abstract

Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by ¹³C-NMR, ¹H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	Journal of Ethnopharmacology
Volume	84
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-8741(02)00318-5
Publication status	Published - 2003 Feb

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University.

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

Access to Document

10.1016/S0378-8741(02)00318-5

Fingerprint Dive into the research topics of 'Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens'. Together they form a unique fingerprint.

Cite this

@article{14f180fb38c9486cb6c5ca5675ebe230,

title = "Kuwanon G: An antibacterial agent from the root bark of Morus alba against oral pathogens",

abstract = "Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.",

author = "Park, {K. M.} and You, {J. S.} and Lee, {H. Y.} and Baek, {N. I.} and Hwang, {J. K.}",

note = "Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University.",

year = "2003",

month = feb,

doi = "10.1016/S0378-8741(02)00318-5",

language = "English",

volume = "84",

pages = "181--185",

journal = "Journal of Ethnopharmacology",

issn = "0378-8741",

publisher = "Elsevier Ireland Ltd",

number = "2-3",

}

TY - JOUR

T1 - Kuwanon G

T2 - An antibacterial agent from the root bark of Morus alba against oral pathogens

AU - Park, K. M.

AU - You, J. S.

AU - Lee, H. Y.

AU - Baek, N. I.

AU - Hwang, J. K.

N1 - Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University.

PY - 2003/2

Y1 - 2003/2

N2 - Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

AB - Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 μg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 μg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

UR - http://www.scopus.com/inward/record.url?scp=0037297779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037297779&partnerID=8YFLogxK

U2 - 10.1016/S0378-8741(02)00318-5

DO - 10.1016/S0378-8741(02)00318-5

M3 - Article

C2 - 12648813

AN - SCOPUS:0037297779

VL - 84

SP - 181

EP - 185

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 2-3

ER -