Purpose: The potential of L-glutamine as a T2 exchange contrast agent in MRI was investigated. Methods: The T2 relaxation rate of L-glutamine solutions prepared in various concentrations was measured at 9.4 T. A series of T2-weighted images in a mouse cancer model was acquired with an L-glutamine solution infusion. Results: The T2 relaxivity caused by the exchange (R2ex) at 37°C was 0.069 s−1 mM−1 and 0.102 s−1 mM−1 for glutamine and glutamate solutions at pH = 7.2, respectively. The R2ex of glutamine at pH = 6.1–6.7 was in the 0.097–0.1 s−1 mM−1 range. No significant dependence of T1 on the concentration of glutamine was observed. The dynamic measurement of T2-weighted images in vivo showed that the glutamine uptake was primarily observed at the localized part of the tumor. Conclusion: L-glutamine can be used as a T2 exchange contrast agent and images of glutamine uptake in vivo can be acquired.
Bibliographical noteFunding Information:
C.G.J. is supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF‐2019R1I1A1A01064082).
C.G.J. is supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2019R1I1A1A01064082).
© 2020 International Society for Magnetic Resonance in Medicine
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging