L-glutamine as a T2 exchange contrast agent

Chan Gyu Joo, Seung Hyun Yang, Yuna Choi, Hye Young Son, Dong Hyun Kim, Yong Min Huh

Research output: Contribution to journalArticle

Abstract

Purpose: The potential of L-glutamine as a T2 exchange contrast agent in MRI was investigated. Methods: The T2 relaxation rate of L-glutamine solutions prepared in various concentrations was measured at 9.4 T. A series of T2-weighted images in a mouse cancer model was acquired with an L-glutamine solution infusion. Results: The T2 relaxivity caused by the exchange (R2ex) at 37°C was 0.069 s−1 mM−1 and 0.102 s−1 mM−1 for glutamine and glutamate solutions at pH = 7.2, respectively. The R2ex of glutamine at pH = 6.1–6.7 was in the 0.097–0.1 s−1 mM−1 range. No significant dependence of T1 on the concentration of glutamine was observed. The dynamic measurement of T2-weighted images in vivo showed that the glutamine uptake was primarily observed at the localized part of the tumor. Conclusion: L-glutamine can be used as a T2 exchange contrast agent and images of glutamine uptake in vivo can be acquired.

Original languageEnglish
Pages (from-to)2055-2062
Number of pages8
JournalMagnetic Resonance in Medicine
Volume84
Issue number4
DOIs
Publication statusAccepted/In press - 2020 Jan 1

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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    Joo, C. G., Yang, S. H., Choi, Y., Son, H. Y., Kim, D. H., & Huh, Y. M. (Accepted/In press). L-glutamine as a T2 exchange contrast agent. Magnetic Resonance in Medicine, 84(4), 2055-2062. https://doi.org/10.1002/mrm.28305