Abstract
Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].
Original language | English |
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Pages (from-to) | 290-297 |
Number of pages | 8 |
Journal | Journal of Natural Medicines |
Volume | 72 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2018 Jan 1 |
Bibliographical note
Funding Information:Acknowledgements This research is funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant Number 104.01-2014.02 and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2011-0025129).
Publisher Copyright:
© 2017, The Japanese Society of Pharmacognosy and Springer Japan KK.
All Science Journal Classification (ASJC) codes
- Molecular Medicine