Abstract
Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].
| Original language | English |
|---|---|
| Pages (from-to) | 290-297 |
| Number of pages | 8 |
| Journal | Journal of Natural Medicines |
| Volume | 72 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities. / Ban, Ninh Khac; Thoa, Nguyen Thi Kim; Linh, Tran My; Trang, Do Thi; Van Kiem, Phan; Nhiem, Nguyen Xuan; Tai, Bui Huu; Van Minh, Chau; Song, Jae Hyoung; Ko, Hyun Jeong; Kim, Seung Hyun.
In: Journal of Natural Medicines, Vol. 72, No. 1, 01.01.2018, p. 290-297.Research output: Contribution to journal › Article
TY - JOUR
T1 - Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities
AU - Ban, Ninh Khac
AU - Thoa, Nguyen Thi Kim
AU - Linh, Tran My
AU - Trang, Do Thi
AU - Van Kiem, Phan
AU - Nhiem, Nguyen Xuan
AU - Tai, Bui Huu
AU - Van Minh, Chau
AU - Song, Jae Hyoung
AU - Ko, Hyun Jeong
AU - Kim, Seung Hyun
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].
AB - Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].
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U2 - 10.1007/s11418-017-1125-2
DO - 10.1007/s11418-017-1125-2
M3 - Article
VL - 72
SP - 290
EP - 297
JO - Natural Medicines
JF - Natural Medicines
SN - 1340-3443
IS - 1
ER -