TY - JOUR
T1 - Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities
AU - Ban, Ninh Khac
AU - Thoa, Nguyen Thi Kim
AU - Linh, Tran My
AU - Trang, Do Thi
AU - Van Kiem, Phan
AU - Nhiem, Nguyen Xuan
AU - Tai, Bui Huu
AU - Van Minh, Chau
AU - Song, Jae Hyoung
AU - Ko, Hyun Jeong
AU - Kim, Seung Hyun
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].
AB - Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].
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U2 - 10.1007/s11418-017-1125-2
DO - 10.1007/s11418-017-1125-2
M3 - Article
C2 - 28914420
AN - SCOPUS:85029521338
VL - 72
SP - 290
EP - 297
JO - Natural Medicines
JF - Natural Medicines
SN - 1340-3443
IS - 1
ER -