Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities

Ninh Khac Ban, Nguyen Thi Kim Thoa, Tran My Linh, Do Thi Trang, Phan Van Kiem, Nguyen Xuan Nhiem, Bui Huu Tai, Chau Van Minh, Jae Hyoung Song, Hyun Jeong Ko, Seung Hyun Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)290-297
Number of pages8
JournalJournal of Natural Medicines
Volume72
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Vitex
Diterpenes
Acids
Antiviral Agents
Phytochemicals
Viruses
Inhibitory Concentration 50
Methanol
Infection
labdane
5,4'-dihydroxy-7,3'-dimethoxyflavone

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Ban, N. K., Thoa, N. T. K., Linh, T. M., Trang, D. T., Van Kiem, P., Nhiem, N. X., ... Kim, S. H. (2018). Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities. Journal of Natural Medicines, 72(1), 290-297. https://doi.org/10.1007/s11418-017-1125-2
Ban, Ninh Khac ; Thoa, Nguyen Thi Kim ; Linh, Tran My ; Trang, Do Thi ; Van Kiem, Phan ; Nhiem, Nguyen Xuan ; Tai, Bui Huu ; Van Minh, Chau ; Song, Jae Hyoung ; Ko, Hyun Jeong ; Kim, Seung Hyun. / Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities. In: Journal of Natural Medicines. 2018 ; Vol. 72, No. 1. pp. 290-297.
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abstract = "Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].",
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Ban, NK, Thoa, NTK, Linh, TM, Trang, DT, Van Kiem, P, Nhiem, NX, Tai, BH, Van Minh, C, Song, JH, Ko, HJ & Kim, SH 2018, 'Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities', Journal of Natural Medicines, vol. 72, no. 1, pp. 290-297. https://doi.org/10.1007/s11418-017-1125-2

Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities. / Ban, Ninh Khac; Thoa, Nguyen Thi Kim; Linh, Tran My; Trang, Do Thi; Van Kiem, Phan; Nhiem, Nguyen Xuan; Tai, Bui Huu; Van Minh, Chau; Song, Jae Hyoung; Ko, Hyun Jeong; Kim, Seung Hyun.

In: Journal of Natural Medicines, Vol. 72, No. 1, 01.01.2018, p. 290-297.

Research output: Contribution to journalArticle

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T1 - Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities

AU - Ban, Ninh Khac

AU - Thoa, Nguyen Thi Kim

AU - Linh, Tran My

AU - Trang, Do Thi

AU - Van Kiem, Phan

AU - Nhiem, Nguyen Xuan

AU - Tai, Bui Huu

AU - Van Minh, Chau

AU - Song, Jae Hyoung

AU - Ko, Hyun Jeong

AU - Kim, Seung Hyun

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].

AB - Abstract: Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A–C (1–3) and eight known compounds, 5,4′-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4′-dihydroxy-7,3′-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively. Graphical abstract: [Figure not available: see fulltext.].

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