Abstract
We present a label-free CMOS field-effect transistor sensing array to detect the surface potential change affected by the negative charge in DNA molecules for real-time monitoring and quantification. The proposed CMOS bio sensor includes a new sensing pixel architecture implemented with correlated double sampling for reducing offset fixed pattern noise and 1/f noise of the sensing devices. We incorporated non-surface binding detection which allows real-time continuous monitoring of DNA concentrations without immobilizing them on the sensing surface. Various concentrations of 19-bp oligonucleotides solution can be discriminated using the prototype device fabricated in 1-μm double-poly double-metal standard CMOS process. The detection limit was measured as 1.1 ng/μl with a dynamic range of 40 dB and the transient response time was measured less than 20 seconds.
Original language | English |
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Article number | 6095639 |
Pages (from-to) | 189-196 |
Number of pages | 8 |
Journal | IEEE Transactions on Biomedical Circuits and Systems |
Volume | 6 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2012 |
All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Electrical and Electronic Engineering