Label-free CMOS bio sensor with on-chip noise reduction scheme for real-time quantitative monitoring of biomolecules

Seong Jin Kim, Euisik Yoon

Research output: Contribution to journalArticle

14 Citations (Scopus)


We present a label-free CMOS field-effect transistor sensing array to detect the surface potential change affected by the negative charge in DNA molecules for real-time monitoring and quantification. The proposed CMOS bio sensor includes a new sensing pixel architecture implemented with correlated double sampling for reducing offset fixed pattern noise and 1/f noise of the sensing devices. We incorporated non-surface binding detection which allows real-time continuous monitoring of DNA concentrations without immobilizing them on the sensing surface. Various concentrations of 19-bp oligonucleotides solution can be discriminated using the prototype device fabricated in 1-μm double-poly double-metal standard CMOS process. The detection limit was measured as 1.1 ng/μl with a dynamic range of 40 dB and the transient response time was measured less than 20 seconds.

Original languageEnglish
Article number6095639
Pages (from-to)189-196
Number of pages8
JournalIEEE Transactions on Biomedical Circuits and Systems
Issue number3
Publication statusPublished - 2012 Jun 6


All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Electrical and Electronic Engineering

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