Label-free CMOS DNA quantification with on-chip noise reduction schemes

Seong Jin Kim, Mithun Shenoi, Kyutae Yoo, Jeoyoung Shim, Wonseok Chung, Christopher Ko, Lee Sup Kim, Euisik Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

We present a label-free CMOS DNA sensor with a new sensing-pixel architecture and background noise reduction scheme. The proposed sensor generates a differential signal between bio-samples and reference buffer solution with significant reduction in offset and gain fixed pattern noise by employing on-chip correlated double sampling circuits. Non-surface-binding detection technique allows to quantify DNA molecules continuously and sequentially and to reuse the sensor by simple washing protocol. By directly reading the negative charges of DNA molecules, DNA concentrations from 1μM to 10μM have been successfully discriminated.

Original languageEnglish
Title of host publicationTRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages947-950
Number of pages4
DOIs
Publication statusPublished - 2007 Dec 1
Event4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 - Lyon, France
Duration: 2007 Jun 102007 Jun 14

Publication series

NameTRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

Other4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07
CountryFrance
CityLyon
Period07/6/1007/6/14

Fingerprint

Noise abatement
Labels
DNA
Sensors
Molecules
Washing
Pixels
Sampling
Networks (circuits)

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

Cite this

Kim, S. J., Shenoi, M., Yoo, K., Shim, J., Chung, W., Ko, C., ... Yoon, E. (2007). Label-free CMOS DNA quantification with on-chip noise reduction schemes. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 947-950). [4300288] (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2007.4300288
Kim, Seong Jin ; Shenoi, Mithun ; Yoo, Kyutae ; Shim, Jeoyoung ; Chung, Wonseok ; Ko, Christopher ; Kim, Lee Sup ; Yoon, Euisik. / Label-free CMOS DNA quantification with on-chip noise reduction schemes. TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. pp. 947-950 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).
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abstract = "We present a label-free CMOS DNA sensor with a new sensing-pixel architecture and background noise reduction scheme. The proposed sensor generates a differential signal between bio-samples and reference buffer solution with significant reduction in offset and gain fixed pattern noise by employing on-chip correlated double sampling circuits. Non-surface-binding detection technique allows to quantify DNA molecules continuously and sequentially and to reuse the sensor by simple washing protocol. By directly reading the negative charges of DNA molecules, DNA concentrations from 1μM to 10μM have been successfully discriminated.",
author = "Kim, {Seong Jin} and Mithun Shenoi and Kyutae Yoo and Jeoyoung Shim and Wonseok Chung and Christopher Ko and Kim, {Lee Sup} and Euisik Yoon",
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Kim, SJ, Shenoi, M, Yoo, K, Shim, J, Chung, W, Ko, C, Kim, LS & Yoon, E 2007, Label-free CMOS DNA quantification with on-chip noise reduction schemes. in TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems., 4300288, TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 947-950, 4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07, Lyon, France, 07/6/10. https://doi.org/10.1109/SENSOR.2007.4300288

Label-free CMOS DNA quantification with on-chip noise reduction schemes. / Kim, Seong Jin; Shenoi, Mithun; Yoo, Kyutae; Shim, Jeoyoung; Chung, Wonseok; Ko, Christopher; Kim, Lee Sup; Yoon, Euisik.

TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 947-950 4300288 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - We present a label-free CMOS DNA sensor with a new sensing-pixel architecture and background noise reduction scheme. The proposed sensor generates a differential signal between bio-samples and reference buffer solution with significant reduction in offset and gain fixed pattern noise by employing on-chip correlated double sampling circuits. Non-surface-binding detection technique allows to quantify DNA molecules continuously and sequentially and to reuse the sensor by simple washing protocol. By directly reading the negative charges of DNA molecules, DNA concentrations from 1μM to 10μM have been successfully discriminated.

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Kim SJ, Shenoi M, Yoo K, Shim J, Chung W, Ko C et al. Label-free CMOS DNA quantification with on-chip noise reduction schemes. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 947-950. 4300288. (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2007.4300288