Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease

Jeong Hoon Hong, Yue Kyung Kim, Jae Seol Park, Ji Eun Lee, Mi Sun Oh, Eun Joo Chung, Jeong Yeon Kim, Young Hee Sung, Chulhyoung Lyoo, Jae Hyeok Lee, Do Young Kwon, Hyun Sook Kim, Hae Won Shin, Sun Ah Park, In Seok Park, Joong Seok Kim, philhyu Lee, Seong Beom Koh, Jong Sam Baik, Sang Jin KimHyeo Il Ma, Jae Woo Kim, Yun Joong Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aside from the glucocerebrosidase gene, the genetic risk factors for cognitive decline in Parkinson's disease (PD) are controversial. We investigated whether the G2385R polymorphism in leucine-rich repeat kinase 2 gene (LRRK2), a risk variant for the development of PD in East Asians, is associated with cognitive dysfunction in PD. We recruited 299 PD patients, consisting of 23 carriers and 276 non-carriers of LRRK2 G2385R, from 14 centers. Global cognitive function was assessed using the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment (MoCA). PD with cognitive dysfunction was defined as an MMSE Z score that, adjusting for age at study entry and years of education, was below -1.0 standard deviations. In multivariate analysis, PD duration, age at study entry and depression were significant risk factors for cognitive dysfunction as assessed by MMSE performance or the MoCA. In linear regression analysis of the association between MMSE Z scores and PD duration, there was no significant difference associated with the LRRK2 G2385R genotype. The interaction terms between PD duration and the LRRK2 G2385R genotype were not significant for the MMSE Z score but were significant for the MoCA. In conclusion, the LRRK2 G2385R genotype may not be associated with cognitive dysfunction in PD.

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalJournal of Clinical Neuroscience
Volume36
DOIs
Publication statusPublished - 2017 Feb 1

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Leucine
Parkinson Disease
Phosphotransferases
Genes
Genotype
Glucosylceramidase
Cognitive Dysfunction
Cognition
Linear Models
Multivariate Analysis
Regression Analysis
Depression
Education

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Hong, Jeong Hoon ; Kim, Yue Kyung ; Park, Jae Seol ; Lee, Ji Eun ; Oh, Mi Sun ; Chung, Eun Joo ; Kim, Jeong Yeon ; Sung, Young Hee ; Lyoo, Chulhyoung ; Lee, Jae Hyeok ; Kwon, Do Young ; Kim, Hyun Sook ; Shin, Hae Won ; Park, Sun Ah ; Park, In Seok ; Kim, Joong Seok ; Lee, philhyu ; Koh, Seong Beom ; Baik, Jong Sam ; Kim, Sang Jin ; Ma, Hyeo Il ; Kim, Jae Woo ; Kim, Yun Joong. / Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease. In: Journal of Clinical Neuroscience. 2017 ; Vol. 36. pp. 108-113.
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title = "Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease",
abstract = "Aside from the glucocerebrosidase gene, the genetic risk factors for cognitive decline in Parkinson's disease (PD) are controversial. We investigated whether the G2385R polymorphism in leucine-rich repeat kinase 2 gene (LRRK2), a risk variant for the development of PD in East Asians, is associated with cognitive dysfunction in PD. We recruited 299 PD patients, consisting of 23 carriers and 276 non-carriers of LRRK2 G2385R, from 14 centers. Global cognitive function was assessed using the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment (MoCA). PD with cognitive dysfunction was defined as an MMSE Z score that, adjusting for age at study entry and years of education, was below -1.0 standard deviations. In multivariate analysis, PD duration, age at study entry and depression were significant risk factors for cognitive dysfunction as assessed by MMSE performance or the MoCA. In linear regression analysis of the association between MMSE Z scores and PD duration, there was no significant difference associated with the LRRK2 G2385R genotype. The interaction terms between PD duration and the LRRK2 G2385R genotype were not significant for the MMSE Z score but were significant for the MoCA. In conclusion, the LRRK2 G2385R genotype may not be associated with cognitive dysfunction in PD.",
author = "Hong, {Jeong Hoon} and Kim, {Yue Kyung} and Park, {Jae Seol} and Lee, {Ji Eun} and Oh, {Mi Sun} and Chung, {Eun Joo} and Kim, {Jeong Yeon} and Sung, {Young Hee} and Chulhyoung Lyoo and Lee, {Jae Hyeok} and Kwon, {Do Young} and Kim, {Hyun Sook} and Shin, {Hae Won} and Park, {Sun Ah} and Park, {In Seok} and Kim, {Joong Seok} and philhyu Lee and Koh, {Seong Beom} and Baik, {Jong Sam} and Kim, {Sang Jin} and Ma, {Hyeo Il} and Kim, {Jae Woo} and Kim, {Yun Joong}",
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Hong, JH, Kim, YK, Park, JS, Lee, JE, Oh, MS, Chung, EJ, Kim, JY, Sung, YH, Lyoo, C, Lee, JH, Kwon, DY, Kim, HS, Shin, HW, Park, SA, Park, IS, Kim, JS, Lee, P, Koh, SB, Baik, JS, Kim, SJ, Ma, HI, Kim, JW & Kim, YJ 2017, 'Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease', Journal of Clinical Neuroscience, vol. 36, pp. 108-113. https://doi.org/10.1016/j.jocn.2016.10.013

Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease. / Hong, Jeong Hoon; Kim, Yue Kyung; Park, Jae Seol; Lee, Ji Eun; Oh, Mi Sun; Chung, Eun Joo; Kim, Jeong Yeon; Sung, Young Hee; Lyoo, Chulhyoung; Lee, Jae Hyeok; Kwon, Do Young; Kim, Hyun Sook; Shin, Hae Won; Park, Sun Ah; Park, In Seok; Kim, Joong Seok; Lee, philhyu; Koh, Seong Beom; Baik, Jong Sam; Kim, Sang Jin; Ma, Hyeo Il; Kim, Jae Woo; Kim, Yun Joong.

In: Journal of Clinical Neuroscience, Vol. 36, 01.02.2017, p. 108-113.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease

AU - Hong, Jeong Hoon

AU - Kim, Yue Kyung

AU - Park, Jae Seol

AU - Lee, Ji Eun

AU - Oh, Mi Sun

AU - Chung, Eun Joo

AU - Kim, Jeong Yeon

AU - Sung, Young Hee

AU - Lyoo, Chulhyoung

AU - Lee, Jae Hyeok

AU - Kwon, Do Young

AU - Kim, Hyun Sook

AU - Shin, Hae Won

AU - Park, Sun Ah

AU - Park, In Seok

AU - Kim, Joong Seok

AU - Lee, philhyu

AU - Koh, Seong Beom

AU - Baik, Jong Sam

AU - Kim, Sang Jin

AU - Ma, Hyeo Il

AU - Kim, Jae Woo

AU - Kim, Yun Joong

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Aside from the glucocerebrosidase gene, the genetic risk factors for cognitive decline in Parkinson's disease (PD) are controversial. We investigated whether the G2385R polymorphism in leucine-rich repeat kinase 2 gene (LRRK2), a risk variant for the development of PD in East Asians, is associated with cognitive dysfunction in PD. We recruited 299 PD patients, consisting of 23 carriers and 276 non-carriers of LRRK2 G2385R, from 14 centers. Global cognitive function was assessed using the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment (MoCA). PD with cognitive dysfunction was defined as an MMSE Z score that, adjusting for age at study entry and years of education, was below -1.0 standard deviations. In multivariate analysis, PD duration, age at study entry and depression were significant risk factors for cognitive dysfunction as assessed by MMSE performance or the MoCA. In linear regression analysis of the association between MMSE Z scores and PD duration, there was no significant difference associated with the LRRK2 G2385R genotype. The interaction terms between PD duration and the LRRK2 G2385R genotype were not significant for the MMSE Z score but were significant for the MoCA. In conclusion, the LRRK2 G2385R genotype may not be associated with cognitive dysfunction in PD.

AB - Aside from the glucocerebrosidase gene, the genetic risk factors for cognitive decline in Parkinson's disease (PD) are controversial. We investigated whether the G2385R polymorphism in leucine-rich repeat kinase 2 gene (LRRK2), a risk variant for the development of PD in East Asians, is associated with cognitive dysfunction in PD. We recruited 299 PD patients, consisting of 23 carriers and 276 non-carriers of LRRK2 G2385R, from 14 centers. Global cognitive function was assessed using the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment (MoCA). PD with cognitive dysfunction was defined as an MMSE Z score that, adjusting for age at study entry and years of education, was below -1.0 standard deviations. In multivariate analysis, PD duration, age at study entry and depression were significant risk factors for cognitive dysfunction as assessed by MMSE performance or the MoCA. In linear regression analysis of the association between MMSE Z scores and PD duration, there was no significant difference associated with the LRRK2 G2385R genotype. The interaction terms between PD duration and the LRRK2 G2385R genotype were not significant for the MMSE Z score but were significant for the MoCA. In conclusion, the LRRK2 G2385R genotype may not be associated with cognitive dysfunction in PD.

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