Lack of association between Mannose Binding Lectin-2 gene polymorphisms and periodontitis: A meta-analysis

Felipe Rodolfo Pereira da Silva, Alessandro Luiz Araújo Bentes Leal, Luigi Nibali, Jae Il Shin, Marcelo Diniz Carvalho, Reyce Santos Koga, Mariana Brasil de Andrade Figueira, Juliana Gomes Galeno, Diana Mota Toro, Zinalton Gomes de Andrade, Nayana Yared Batista, José Fernando Marques Barcellos

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The aim of this study was to perform a meta-analysis to verify whether MBL-2 gene polymorphisms (rs1800450 and rs1800451) are associated with susceptibility to periodontitis. A search of the literature was performed for studies published before 2, March 2020 in various databases. Calculations of Odds Ratio (OR) with 95% of Confidence Intervals (CI) and heterogeneity (I2) were assessed and publication bias was calculated by Begg’ and Egger's test. The value of P < .05 was considered as significant. As results, eight articles composed the results which non-significant associations were found for all included comparisons (P > .05). Neither the mutant allele in rs1800450 polymorphisms nor the mutant allele in rs1800451 polymorphisms was associated with periodontitis (OR = 1.11, CI: 0.90–1.38, P = .33; OR = 1.01, CI: 0.75–1.35, P = .96, respectively) with no interference of I2 in these evaluations (I2 = 0%, P = .75 and I2 = 0%, P = .65, respectively) as well as in all calculations. The stratified analyses were composed by Ethnicity in Caucasian and Mixed populations and genotyping methods. In conclusion, this meta-analysis showed a non-significant association among the rs1800450 and 1,800,451 polymorphism in MBL-2 gene and periodontitis in the overall evaluation, Caucasian group and Mixed population.

Original languageEnglish
Article number100757
JournalMeta Gene
Publication statusPublished - 2020 Dec

Bibliographical note

Publisher Copyright:
© 2020 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)


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