Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia

Jung Yoon Hee, JunYong Choi, Oh Kim Chang, Seon Park Yoon, Soo Kim Myoung, YoungKeun Kim, Youn Shin So, Myung Kim June, Goo Song Young

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.

Original languageEnglish
Pages (from-to)979-982
Number of pages4
JournalJournal of Korean Medical Science
Volume21
Issue number6
Publication statusPublished - 2006 Dec 1

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Toll-Like Receptor 2
Toll-Like Receptor 4
Toll-Like Receptors
Bacteremia
Restriction Fragment Length Polymorphisms
Alleles
Pattern Recognition Receptors
Polymerase Chain Reaction
Genetic Polymorphisms
Korea
Bacterial Infections
Innate Immunity
Genes
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hee, J. Y., Choi, J., Chang, O. K., Yoon, S. P., Myoung, S. K., Kim, Y., ... Young, G. S. (2006). Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia. Journal of Korean Medical Science, 21(6), 979-982.
Hee, Jung Yoon ; Choi, JunYong ; Chang, Oh Kim ; Yoon, Seon Park ; Myoung, Soo Kim ; Kim, YoungKeun ; So, Youn Shin ; June, Myung Kim ; Young, Goo Song. / Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia. In: Journal of Korean Medical Science. 2006 ; Vol. 21, No. 6. pp. 979-982.
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Hee, JY, Choi, J, Chang, OK, Yoon, SP, Myoung, SK, Kim, Y, So, YS, June, MK & Young, GS 2006, 'Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia', Journal of Korean Medical Science, vol. 21, no. 6, pp. 979-982.

Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia. / Hee, Jung Yoon; Choi, JunYong; Chang, Oh Kim; Yoon, Seon Park; Myoung, Soo Kim; Kim, YoungKeun; So, Youn Shin; June, Myung Kim; Young, Goo Song.

In: Journal of Korean Medical Science, Vol. 21, No. 6, 01.12.2006, p. 979-982.

Research output: Contribution to journalArticle

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