Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis

Kwang Kyun Park, Kyung Soo Chun, Jong I.N. Yook, Young Joon Surh

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Capsaicin (trans-8-)methyl-N-vanillyl-6-nonenamide) is the major pungent principle of hot peppers of the genus Capsicum. There have been numerous investigations to evaluate the effects of capsaicin on experimental carcinogenesis and mutagenesis, but the results are discordant. In the present study, we have assessed the tumor promoting potential of capsaicin using a two stage mouse skin carcinogenesis model. Repeated applications of capsaicin (10 μmol) onto the shaven backs of female ICR mice following a single-initiation dose of 7,12-dimethylbenz[a]anthracene did not cause any significant increase in papilloma formation and abnormal hyperplastic or inflammatory skin lesions, compared with the solvent control. Furthermore, the topical application of capsaicin did not induce the epidermal ornithine decarboxylase activity, suggesting that it lack tumor-promotional activity. On the contrary, the compound ameliorated the mouse skin carcinogenesis when given simultaneously with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.

Original languageEnglish
Pages (from-to)4201-4205
Number of pages5
JournalAnticancer research
Volume18
Issue number6 A
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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