Background: The aim of this study was to determine the relationship of the central corneal thickness (CCT) and axial length (AXL) with the central lamina cribrosa thickness (LCT) in healthy human eyes. Methods: This was a prospective observational case series. The optic discs of 189 eyes from 100 healthy subjects with a refractive error smaller than -8 diopters were scanned using enhanced-depth imaging spectral-domain optical coherence tomography (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany). The thickness of the lamina cribrosa (LC) was measured on B-scan images obtained at the center of the optic nerve head. A linear mixed-effects model was used to determine the factors associated with LCT, taking into account clustering of eyes within subjects. Results: The thickness of the central LC was 273.19 ± 34.74 μm (mean ± SD; range, 173.73-367.94 μm). Multivariate analysis revealed a significant influence of older age on increased central LCT (p = 0.001). There was no significant association between central LCT and either CCT or AXL. Conclusions: In this study, the central LCT increased significantly with older age in healthy human eyes. Neither CCT nor AXL was significantly associated with the central LCT in healthy human eyes with a spherical equivalent within the range from -7.0 to +3.0 diopters.
|Number of pages||8|
|Journal||Graefe's Archive for Clinical and Experimental Ophthalmology|
|Publication status||Published - 2013 Mar|
Bibliographical noteFunding Information:
Funding/support This work is supported by National Research Foundation of Korea Grant funded by the Korean Government (2010-0004210).
All Science Journal Classification (ASJC) codes
- Sensory Systems
- Cellular and Molecular Neuroscience