Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation

Jaemin Shim, Hye Jin Hwang, huinam pak, Moon Hyoung Lee, Boyoung Joung

Research output: Contribution to journalArticle

Abstract

Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7% vs. 21.1%, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95% CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95% CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95% CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95% CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.

Original languageEnglish
Number of pages1
JournalJournal of Arrhythmia
Volume27
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1

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Atrial Appendage
Atrial Fibrillation
Stroke
Thromboembolism
Multivariate Analysis
Tomography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{06e8c607a2454fe4a689fe90cd8b07cd,
title = "Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation",
abstract = "Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7{\%} vs. 21.1{\%}, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95{\%} CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95{\%} CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95{\%} CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95{\%} CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.",
author = "Jaemin Shim and Hwang, {Hye Jin} and huinam pak and Lee, {Moon Hyoung} and Boyoung Joung",
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Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation. / Shim, Jaemin; Hwang, Hye Jin; pak, huinam; Lee, Moon Hyoung; Joung, Boyoung.

In: Journal of Arrhythmia, Vol. 27, No. 4, 01.01.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Larger Left Atrial Appendage Is an Independent Predictor of Stroke in Patients with Atrial Fibrillation

AU - Shim, Jaemin

AU - Hwang, Hye Jin

AU - pak, huinam

AU - Lee, Moon Hyoung

AU - Joung, Boyoung

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N2 - Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7% vs. 21.1%, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95% CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95% CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95% CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95% CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.

AB - Background: Left atrial appendage (LAA) is an important source of thromboembolism in patients with atrial fibrillation (AF). This study evaluated the features of LAA associated with stroke in patients with AF. Methods: We compared the size of LAA using computed tomography (CT) between 224 AF patients with non-hemorrhagic stroke (Group 1, 71 women, age 67± 10 years) and 365 AF patients without stroke (Group 2, 77 women, age 56 ±11 years). Results: Group 1 included more female patients (31.7% vs. 21.1%, p=0.004), and was older than group 2 (p<0.001). There was no difference in the type of AF between two groups. CHADS2 score (3.2 ±0.8, vs. 0.6±0.7, p<0.001) and LA dimension (4.76±0.82 vs. 4.12±0.59 cm, p<0.001) were significantly lager in group 1 than group 2. The orifice size (3.85± 1.66 vs. 2.57±0.93 cm2, p<0.001) and depth of LAA (3.18±0.67 vs. 2.67±0.57 cm, p<0.001) were significantly larger in group 1 than group 2. In multivariate analysis, age (OR 2.08 per decade increase, 95% CI 1.59-2.71, p<0.001), LA size (OR 1.89, 95% CI 1.29-2.76, p=0.001), the orifice size (OR 1.58, 95% CI 1.26-1.99, p<0.001) and the depth of LAA (OR 1.91, 95% CI 1.24-2.95, p=0.004) were independent predictors of stroke. Conclusion: In patients with non-valvular atrial fibrillation, the larger orifice size and depth of LAA were independent predictors of stroke with advanced age and LA enlargement.

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