Dissolving microneedle (DMN) is an attractive alternative to parenteral and enteral drug administration owing to its painless self-administration and safety due to non-generation of medical waste. For reproducible and efficient DMN administration, various DMN application methods, such as weights, springs, and electromagnetic devices, have been studied. However, these applicators have complex structures that are complicated to use and high production costs. In this study, a latch applicator that consists of only simple plastic parts and operates via thumb force without any external complex device is developed. Protrusion-shaped latches and impact distances are designed to accumulate thumb force energy through elastic deformation and to control impact velocity. The optimized latch applicator with a pressing force of 25 N and an impact velocity of 5.9 m s−1 fully inserts the drug-loaded tip of the two-layered DMN into the skin. In an ovalbumin immunization test, DMN with the latch applicator shows a significantly higher IgG antibody production rate than that of intramuscular injection. The latch applicator, which provides effective DMN insertion and a competitive price compared with conventional syringes, has great potential to improve delivery of drugs, including vaccines.
|Journal||Advanced Functional Materials|
|Publication status||Published - 2023 Mar 9|
Bibliographical noteFunding Information:
This work was supported by the Industrial Core Technology Development Program (20000462, Development of anti‐aging beauty care system using multi active and controlled releasing transdermal delivery for skin layer specific effects) funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea) and a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HV22C0084).
© 2023 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH.
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Condensed Matter Physics