Late-acquired incomplete stent apposition after everolimuseluting stent versus sirolimus-eluting stent implantation in patients with non-ST-segment elevation myocardial infarction and ST-segment elevation myocardial infarction (APPOSITION-AMI)

Seung Ho Hur, Bong Ryeol Lee, Sang Wook Kim, Young Joon Hong, Jang Ho Bae, Donghoon Choi, Hyun Jae Kang, So Yeon Choi, Sang Gon Lee, Doo Il Kim, Jong Seon Park, Seung Woon Rha

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Aims: Our aim was to evaluate the incidence and clinical outcomes of late-acquired incomplete stent apposition (LAISA) after implantation of first-and second-generation drug-eluting stents in patients with acute myocardial infarction (AMI). Methods and results: Late-Acquired incomplete stent aPPOsition after everolimus-eluting stent versus sirolimus-eluting Stent ImplanTatION in pAtients with non ST-segment elevation Myocardial Infarction and ST-segment elevation myocardial infarction (APPOSITION-AMI) was a prospective, randomised study comparing LAISA after everolimus-eluting stent (EES) and sirolimus-eluting stent (SES) implantation in AMI patients. Intravascular ultrasound examination was serially performed post-procedurally and at eight-month follow-up in 195 AMI patients (205 native coronary lesions: 100 EES; 105 SES). LAISA was observed in 6.0% and 16.2% of EES-vs. SES-treated lesions (p=0.021), respectively. In 64.7% of SEStreated lesions, LAISA was caused by positive remodelling, whereas thrombus dissolution or plaque reduction was observed in 66.7% of EES-treated lesions. Among patients with LAISA, MACE developed in one (4.5%) in the SES group with no ST in either group up to one year. Conclusions: The incidence of LAISA was lower in AMI patients treated with EES as compared to SES, mainly secondary to positive remodelling in SES-but not EES-treated lesions. Patients with LAISA in both groups showed a very low MACE incidence at one-year follow-up.

Original languageEnglish
Pages (from-to)e979-e986
Issue number8
Publication statusPublished - 2016 Oct


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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