LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis

Chan Ho Kim, Seung Jun Kim, Mi Jung Lee, Young Eun Kwon, Yung Ly Kim, Kyoung Sook Park, Han Jak Ryu, Hyung Jung Oh, SeungHyeok Han, TaeHyun Yoo, Yong Lim Kim, Yon Su Kim, Chul Woo Yang, Nam Ho Kim, Shin-Wook Kang, Jung Tak Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis. Methods: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables. Results: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP. Conclusion: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalBlood Purification
Volume38
Issue number2
DOIs
Publication statusPublished - 2014 May 22

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LDL Cholesterol
Renal Dialysis
Dialysis
Preexisting Condition Coverage
Albumins
Diabetes Mellitus
Cholesterol
Regression Analysis
Lipids
Mortality
Serum

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

Kim, C. H., Kim, S. J., Lee, M. J., Kwon, Y. E., Kim, Y. L., Park, K. S., ... Park, J. T. (2014). LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis. Blood Purification, 38(2), 131-139. https://doi.org/10.1159/000367803
Kim, Chan Ho ; Kim, Seung Jun ; Lee, Mi Jung ; Kwon, Young Eun ; Kim, Yung Ly ; Park, Kyoung Sook ; Ryu, Han Jak ; Oh, Hyung Jung ; Han, SeungHyeok ; Yoo, TaeHyun ; Kim, Yong Lim ; Kim, Yon Su ; Yang, Chul Woo ; Kim, Nam Ho ; Kang, Shin-Wook ; Park, Jung Tak. / LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis. In: Blood Purification. 2014 ; Vol. 38, No. 2. pp. 131-139.
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abstract = "Background/Aims: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis. Methods: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables. Results: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP. Conclusion: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.",
author = "Kim, {Chan Ho} and Kim, {Seung Jun} and Lee, {Mi Jung} and Kwon, {Young Eun} and Kim, {Yung Ly} and Park, {Kyoung Sook} and Ryu, {Han Jak} and Oh, {Hyung Jung} and SeungHyeok Han and TaeHyun Yoo and Kim, {Yong Lim} and Kim, {Yon Su} and Yang, {Chul Woo} and Kim, {Nam Ho} and Shin-Wook Kang and Park, {Jung Tak}",
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Kim, CH, Kim, SJ, Lee, MJ, Kwon, YE, Kim, YL, Park, KS, Ryu, HJ, Oh, HJ, Han, S, Yoo, T, Kim, YL, Kim, YS, Yang, CW, Kim, NH, Kang, S-W & Park, JT 2014, 'LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis', Blood Purification, vol. 38, no. 2, pp. 131-139. https://doi.org/10.1159/000367803

LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis. / Kim, Chan Ho; Kim, Seung Jun; Lee, Mi Jung; Kwon, Young Eun; Kim, Yung Ly; Park, Kyoung Sook; Ryu, Han Jak; Oh, Hyung Jung; Han, SeungHyeok; Yoo, TaeHyun; Kim, Yong Lim; Kim, Yon Su; Yang, Chul Woo; Kim, Nam Ho; Kang, Shin-Wook; Park, Jung Tak.

In: Blood Purification, Vol. 38, No. 2, 22.05.2014, p. 131-139.

Research output: Contribution to journalArticle

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T1 - LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis

AU - Kim, Chan Ho

AU - Kim, Seung Jun

AU - Lee, Mi Jung

AU - Kwon, Young Eun

AU - Kim, Yung Ly

AU - Park, Kyoung Sook

AU - Ryu, Han Jak

AU - Oh, Hyung Jung

AU - Han, SeungHyeok

AU - Yoo, TaeHyun

AU - Kim, Yong Lim

AU - Kim, Yon Su

AU - Yang, Chul Woo

AU - Kim, Nam Ho

AU - Kang, Shin-Wook

AU - Park, Jung Tak

PY - 2014/5/22

Y1 - 2014/5/22

N2 - Background/Aims: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis. Methods: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables. Results: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP. Conclusion: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.

AB - Background/Aims: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis. Methods: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables. Results: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP. Conclusion: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.

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