LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis

Chan Ho Kim, Seung Jun Kim, Mi Jung Lee, Young Eun Kwon, Yung Ly Kim, Kyoung Sook Park, Han Jak Ryu, Hyung Jung Oh, Seung Hyeok Han, Tae Hyun Yoo, Yong Lim Kim, Yon Su Kim, Chul Woo Yang, Nam Ho Kim, Shin Wook Kang, Jung Tak Park

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Abstract

Background/Aims: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis. Methods: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables. Results: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP. Conclusion: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalBlood Purification
Volume38
Issue number2
DOIs
Publication statusPublished - 2014 May 22

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

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    Kim, C. H., Kim, S. J., Lee, M. J., Kwon, Y. E., Kim, Y. L., Park, K. S., Ryu, H. J., Oh, H. J., Han, S. H., Yoo, T. H., Kim, Y. L., Kim, Y. S., Yang, C. W., Kim, N. H., Kang, S. W., & Park, J. T. (2014). LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis. Blood Purification, 38(2), 131-139. https://doi.org/10.1159/000367803