LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis

Chan Ho Kim; Seung Jun Kim; Mi Jung Lee; Young Eun Kwon; Yung Ly Kim; Kyoung Sook Park; Han Jak Ryu; Hyung Jung Oh; Seung Hyeok Han; Tae Hyun Yoo; Yong Lim Kim; Yon Su Kim; Chul Woo Yang; Nam Ho Kim; Shin Wook Kang; Jung Tak Park

doi:10.1159/000367803

LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis

Chan Ho Kim, Seung Jun Kim, Mi Jung Lee, Young Eun Kwon, Yung Ly Kim, Kyoung Sook Park, Han Jak Ryu, Hyung Jung Oh, Seung Hyeok Han, Tae Hyun Yoo, Yong Lim Kim, Yon Su Kim, Chul Woo Yang, Nam Ho Kim, Shin Wook Kang, Jung Tak Park

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background/Aims: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis. Methods: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables. Results: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP. Conclusion: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.

Original language	English
Pages (from-to)	131-139
Number of pages	9
Journal	Blood Purification
Volume	38
Issue number	2
DOIs	https://doi.org/10.1159/000367803
Publication status	Published - 2014 May 22

Bibliographical note

Publisher Copyright:
© 2014 S. Karger AG, Basel.

All Science Journal Classification (ASJC) codes

Hematology
Nephrology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000367803

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Kim, C. H., Kim, S. J., Lee, M. J., Kwon, Y. E., Kim, Y. L., Park, K. S., Ryu, H. J., Oh, H. J., Han, S. H., Yoo, T. H., Kim, Y. L., Kim, Y. S., Yang, C. W., Kim, N. H., Kang, S. W., & Park, J. T. (2014). LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis. Blood Purification, 38(2), 131-139. https://doi.org/10.1159/000367803

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abstract = "Background/Aims: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis. Methods: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables. Results: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP. Conclusion: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.",

author = "Kim, {Chan Ho} and Kim, {Seung Jun} and Lee, {Mi Jung} and Kwon, {Young Eun} and Kim, {Yung Ly} and Park, {Kyoung Sook} and Ryu, {Han Jak} and Oh, {Hyung Jung} and Han, {Seung Hyeok} and Yoo, {Tae Hyun} and Kim, {Yong Lim} and Kim, {Yon Su} and Yang, {Chul Woo} and Kim, {Nam Ho} and Kang, {Shin Wook} and Park, {Jung Tak}",

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doi = "10.1159/000367803",

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AU - Kim, Chan Ho

AU - Kim, Seung Jun

AU - Lee, Mi Jung

AU - Kwon, Young Eun

AU - Kim, Yung Ly

AU - Park, Kyoung Sook

AU - Ryu, Han Jak

AU - Oh, Hyung Jung

AU - Han, Seung Hyeok

AU - Yoo, Tae Hyun

AU - Kim, Yong Lim

AU - Kim, Yon Su

AU - Yang, Chul Woo

AU - Kim, Nam Ho

AU - Kang, Shin Wook

AU - Park, Jung Tak

PY - 2014/5/22

Y1 - 2014/5/22

N2 - Background/Aims: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis. Methods: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables. Results: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP. Conclusion: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.

AB - Background/Aims: Using a cohort of incident hemodialysis (HD) patients, this study investigated the impact of lipid profiles on clinical outcomes, especially in the early period of dialysis. Methods: A prospective cohort of 867 incident HD patients was selected. In order to determine the impact of cholesterol level on primary outcome, Cox regression analyses were performed for LDL and non-HDL (NHDL) variables. Results: Univariate analysis revealed an increase in primary outcome risk with an LDL cholesterol level of 100 mg/dl or higher compared to an LDL cholesterol level lower than 100 mg/dl. High LDL cholesterol remained a significant independent predictor of the composite outcome, even after adjusting for age, gender, diabetes mellitus, preexisting CV disease, albumin, and hs-CRP. Conclusion: Serum LDL cholesterol at the time of HD commencement was a significant independent risk factor for the composite outcome of all-cause mortality and CV events in incident HD patients during the early stages of dialysis.

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LDL cholesterol affects clinical outcomes in incident hemodialysis patients during the early stages of dialysis

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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