Abstract
Background: Left atrial (LA) volume index (LAVI) has been considered a stable indicator of diastolic dysfunction and an independent predictor of mortality in patients with end-stage renal disease. To date, however, little is known about the relationship between LA enlargement and the changes in residual renal function (RRF). Methods: This study was undertaken to investigate the association between LA enlargement and the decline in RRF in 121 incident peritoneal dialysis patients. Within 2 months after the initiation of peritoneal dialysis, LA enlargement was determined by echocardiography and RRF by 24-hour urine collection. Subsequently, RRF was measured every 6 months. Results: The rates of decline in RRF were significantly greater in patients with LA enlargement (LAVI > 32 mL/m 2) compared with those without LA enlargement (-0.17 ± 0.18 vs -0.07 ± 0.16 mL/min/month/1.73 m 2, P = .002). In a linear mixed model, there was a significant difference in the rates of RRF decline over time between patients with and without LA enlargement (P <.001). Pearson's correlation analysis revealed that there were significant inverse correlations between the rates of the decline in RRF and LAVI (r = -0.22, P =.018). In multiple linear regression analysis adjusted for other risk factors, LAVI was found to be an independent determinant of the rates of decline in RRF (β = -0.026, P =.018). Conclusions: This study shows that a higher LAVI is independently associated with a more rapid decline in RRF in patients with end-stage renal disease on peritoneal dialysis.
| Original language | English |
|---|---|
| Pages (from-to) | 421-427 |
| Number of pages | 7 |
| Journal | Journal of the American Society of Echocardiography |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2012 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
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Left atrial enlargement is associated with a rapid decline in residual renal function in ESRD patients on peritoneal dialysis. / Kim, Seung Jun; Oh, Hyung Jung; Yoo, Dong Eun; Shin, Dong Ho; Lee, Mi Jung; Park, Jung Tak; Han, Seung Hyeok; Yoo, Tae Hyun; Choi, Kyu Hun; Kang, Shin Wook.
In: Journal of the American Society of Echocardiography, Vol. 25, No. 4, 01.04.2012, p. 421-427.Research output: Contribution to journal › Article
TY - JOUR
T1 - Left atrial enlargement is associated with a rapid decline in residual renal function in ESRD patients on peritoneal dialysis
AU - Kim, Seung Jun
AU - Oh, Hyung Jung
AU - Yoo, Dong Eun
AU - Shin, Dong Ho
AU - Lee, Mi Jung
AU - Park, Jung Tak
AU - Han, Seung Hyeok
AU - Yoo, Tae Hyun
AU - Choi, Kyu Hun
AU - Kang, Shin Wook
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Background: Left atrial (LA) volume index (LAVI) has been considered a stable indicator of diastolic dysfunction and an independent predictor of mortality in patients with end-stage renal disease. To date, however, little is known about the relationship between LA enlargement and the changes in residual renal function (RRF). Methods: This study was undertaken to investigate the association between LA enlargement and the decline in RRF in 121 incident peritoneal dialysis patients. Within 2 months after the initiation of peritoneal dialysis, LA enlargement was determined by echocardiography and RRF by 24-hour urine collection. Subsequently, RRF was measured every 6 months. Results: The rates of decline in RRF were significantly greater in patients with LA enlargement (LAVI > 32 mL/m 2) compared with those without LA enlargement (-0.17 ± 0.18 vs -0.07 ± 0.16 mL/min/month/1.73 m 2, P = .002). In a linear mixed model, there was a significant difference in the rates of RRF decline over time between patients with and without LA enlargement (P <.001). Pearson's correlation analysis revealed that there were significant inverse correlations between the rates of the decline in RRF and LAVI (r = -0.22, P =.018). In multiple linear regression analysis adjusted for other risk factors, LAVI was found to be an independent determinant of the rates of decline in RRF (β = -0.026, P =.018). Conclusions: This study shows that a higher LAVI is independently associated with a more rapid decline in RRF in patients with end-stage renal disease on peritoneal dialysis.
AB - Background: Left atrial (LA) volume index (LAVI) has been considered a stable indicator of diastolic dysfunction and an independent predictor of mortality in patients with end-stage renal disease. To date, however, little is known about the relationship between LA enlargement and the changes in residual renal function (RRF). Methods: This study was undertaken to investigate the association between LA enlargement and the decline in RRF in 121 incident peritoneal dialysis patients. Within 2 months after the initiation of peritoneal dialysis, LA enlargement was determined by echocardiography and RRF by 24-hour urine collection. Subsequently, RRF was measured every 6 months. Results: The rates of decline in RRF were significantly greater in patients with LA enlargement (LAVI > 32 mL/m 2) compared with those without LA enlargement (-0.17 ± 0.18 vs -0.07 ± 0.16 mL/min/month/1.73 m 2, P = .002). In a linear mixed model, there was a significant difference in the rates of RRF decline over time between patients with and without LA enlargement (P <.001). Pearson's correlation analysis revealed that there were significant inverse correlations between the rates of the decline in RRF and LAVI (r = -0.22, P =.018). In multiple linear regression analysis adjusted for other risk factors, LAVI was found to be an independent determinant of the rates of decline in RRF (β = -0.026, P =.018). Conclusions: This study shows that a higher LAVI is independently associated with a more rapid decline in RRF in patients with end-stage renal disease on peritoneal dialysis.
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U2 - 10.1016/j.echo.2011.12.005
DO - 10.1016/j.echo.2011.12.005
M3 - Article
C2 - 22222197
AN - SCOPUS:84859162522
VL - 25
SP - 421
EP - 427
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
SN - 0894-7317
IS - 4
ER -