Left atrial enlargement is associated with a rapid decline in residual renal function in ESRD patients on peritoneal dialysis

Seung Jun Kim, Hyung Jung Oh, Dong Eun Yoo, Dong Ho Shin, Mi Jung Lee, Jung Tak Park, Seung Hyeok Han, Tae Hyun Yoo, Kyu Hun Choi, Shin Wook Kang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Left atrial (LA) volume index (LAVI) has been considered a stable indicator of diastolic dysfunction and an independent predictor of mortality in patients with end-stage renal disease. To date, however, little is known about the relationship between LA enlargement and the changes in residual renal function (RRF). Methods: This study was undertaken to investigate the association between LA enlargement and the decline in RRF in 121 incident peritoneal dialysis patients. Within 2 months after the initiation of peritoneal dialysis, LA enlargement was determined by echocardiography and RRF by 24-hour urine collection. Subsequently, RRF was measured every 6 months. Results: The rates of decline in RRF were significantly greater in patients with LA enlargement (LAVI > 32 mL/m 2) compared with those without LA enlargement (-0.17 ± 0.18 vs -0.07 ± 0.16 mL/min/month/1.73 m 2, P = .002). In a linear mixed model, there was a significant difference in the rates of RRF decline over time between patients with and without LA enlargement (P <.001). Pearson's correlation analysis revealed that there were significant inverse correlations between the rates of the decline in RRF and LAVI (r = -0.22, P =.018). In multiple linear regression analysis adjusted for other risk factors, LAVI was found to be an independent determinant of the rates of decline in RRF (β = -0.026, P =.018). Conclusions: This study shows that a higher LAVI is independently associated with a more rapid decline in RRF in patients with end-stage renal disease on peritoneal dialysis.

Original languageEnglish
Pages (from-to)421-427
Number of pages7
JournalJournal of the American Society of Echocardiography
Volume25
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

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Peritoneal Dialysis
Chronic Kidney Failure
Kidney
Linear Models
Urine Specimen Collection
Echocardiography
Regression Analysis
Mortality

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Kim, Seung Jun ; Oh, Hyung Jung ; Yoo, Dong Eun ; Shin, Dong Ho ; Lee, Mi Jung ; Park, Jung Tak ; Han, Seung Hyeok ; Yoo, Tae Hyun ; Choi, Kyu Hun ; Kang, Shin Wook. / Left atrial enlargement is associated with a rapid decline in residual renal function in ESRD patients on peritoneal dialysis. In: Journal of the American Society of Echocardiography. 2012 ; Vol. 25, No. 4. pp. 421-427.
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Left atrial enlargement is associated with a rapid decline in residual renal function in ESRD patients on peritoneal dialysis. / Kim, Seung Jun; Oh, Hyung Jung; Yoo, Dong Eun; Shin, Dong Ho; Lee, Mi Jung; Park, Jung Tak; Han, Seung Hyeok; Yoo, Tae Hyun; Choi, Kyu Hun; Kang, Shin Wook.

In: Journal of the American Society of Echocardiography, Vol. 25, No. 4, 01.04.2012, p. 421-427.

Research output: Contribution to journalArticle

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T1 - Left atrial enlargement is associated with a rapid decline in residual renal function in ESRD patients on peritoneal dialysis

AU - Kim, Seung Jun

AU - Oh, Hyung Jung

AU - Yoo, Dong Eun

AU - Shin, Dong Ho

AU - Lee, Mi Jung

AU - Park, Jung Tak

AU - Han, Seung Hyeok

AU - Yoo, Tae Hyun

AU - Choi, Kyu Hun

AU - Kang, Shin Wook

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N2 - Background: Left atrial (LA) volume index (LAVI) has been considered a stable indicator of diastolic dysfunction and an independent predictor of mortality in patients with end-stage renal disease. To date, however, little is known about the relationship between LA enlargement and the changes in residual renal function (RRF). Methods: This study was undertaken to investigate the association between LA enlargement and the decline in RRF in 121 incident peritoneal dialysis patients. Within 2 months after the initiation of peritoneal dialysis, LA enlargement was determined by echocardiography and RRF by 24-hour urine collection. Subsequently, RRF was measured every 6 months. Results: The rates of decline in RRF were significantly greater in patients with LA enlargement (LAVI > 32 mL/m 2) compared with those without LA enlargement (-0.17 ± 0.18 vs -0.07 ± 0.16 mL/min/month/1.73 m 2, P = .002). In a linear mixed model, there was a significant difference in the rates of RRF decline over time between patients with and without LA enlargement (P <.001). Pearson's correlation analysis revealed that there were significant inverse correlations between the rates of the decline in RRF and LAVI (r = -0.22, P =.018). In multiple linear regression analysis adjusted for other risk factors, LAVI was found to be an independent determinant of the rates of decline in RRF (β = -0.026, P =.018). Conclusions: This study shows that a higher LAVI is independently associated with a more rapid decline in RRF in patients with end-stage renal disease on peritoneal dialysis.

AB - Background: Left atrial (LA) volume index (LAVI) has been considered a stable indicator of diastolic dysfunction and an independent predictor of mortality in patients with end-stage renal disease. To date, however, little is known about the relationship between LA enlargement and the changes in residual renal function (RRF). Methods: This study was undertaken to investigate the association between LA enlargement and the decline in RRF in 121 incident peritoneal dialysis patients. Within 2 months after the initiation of peritoneal dialysis, LA enlargement was determined by echocardiography and RRF by 24-hour urine collection. Subsequently, RRF was measured every 6 months. Results: The rates of decline in RRF were significantly greater in patients with LA enlargement (LAVI > 32 mL/m 2) compared with those without LA enlargement (-0.17 ± 0.18 vs -0.07 ± 0.16 mL/min/month/1.73 m 2, P = .002). In a linear mixed model, there was a significant difference in the rates of RRF decline over time between patients with and without LA enlargement (P <.001). Pearson's correlation analysis revealed that there were significant inverse correlations between the rates of the decline in RRF and LAVI (r = -0.22, P =.018). In multiple linear regression analysis adjusted for other risk factors, LAVI was found to be an independent determinant of the rates of decline in RRF (β = -0.026, P =.018). Conclusions: This study shows that a higher LAVI is independently associated with a more rapid decline in RRF in patients with end-stage renal disease on peritoneal dialysis.

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