Left Atrial Volume as a Predictor of Left Ventricular Functional Recovery in Patients With Dilated Cardiomyopathy and Absence of Delayed Enhancement in Cardiac Magnetic Resonance

Jeonggeun Moon, ChiYoung Shim, Youngjin Kim, Sungha Park, seokmin kang, Namsik Chung, Jong Won Ha

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5 Citations (Scopus)

Abstract

Background Improvement of left ventricular (LV) systolic dysfunction can occur in patients with dilated cardiomyopathy (DCM), and it is more frequently observed if patients have no delayed enhancement (DE) in cardiac magnetic resonance imaging (CMR). However, even in the absence of DE, not all patients have functional recovery. We retrospectively investigated the predictors of LV functional recovery in patients with DCM who had no DE in CMR. Methods A total of 136 patients with DCM underwent CMR. Among them, 44 (29 male, age 55 ± 14 years) showed no DE and these patients composed the study population. The study patients were divided into 2 groups according to the occurrence of functional recovery defined as an increase in LV ejection fraction to a level of ≥50% and net increase in ejection fraction of 20% or more: group 1 (n = 14) with functional recovery and group 2 (n = 30) without functional recovery. Results In patients who showed functional recovery, left atrial volume index (LAVI [26 ± 8 mL/m2 vs 45 ± 18 mL/m2]) and LV end-diastolic dimension (62 ± 6 mm vs 67 ± 7 mm) were significantly smaller when compared with those without functional recovery (P < .05 for all). In Cox multiple regression analysis, LAVI was the only significant parameter associated with LV functional recovery (hazard ratio 0.932, 95% confidence interval 0.877–0.991, P = .024). LAVI < 38 mL/m2 had 100% specificity in predicting the improvement of LV systolic dysfunction. Conclusion In DCM patients who had no DE in CMR, LAVI predicts LV functional recovery with high specificity.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalJournal of Cardiac Failure
Volume22
Issue number4
DOIs
Publication statusPublished - 2016 Jan 1

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Dilated Cardiomyopathy
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Left Ventricular Dysfunction
Stroke Volume
Regression Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{60f2e8b1e7b049a885397e982fc37ee6,
title = "Left Atrial Volume as a Predictor of Left Ventricular Functional Recovery in Patients With Dilated Cardiomyopathy and Absence of Delayed Enhancement in Cardiac Magnetic Resonance",
abstract = "Background Improvement of left ventricular (LV) systolic dysfunction can occur in patients with dilated cardiomyopathy (DCM), and it is more frequently observed if patients have no delayed enhancement (DE) in cardiac magnetic resonance imaging (CMR). However, even in the absence of DE, not all patients have functional recovery. We retrospectively investigated the predictors of LV functional recovery in patients with DCM who had no DE in CMR. Methods A total of 136 patients with DCM underwent CMR. Among them, 44 (29 male, age 55 ± 14 years) showed no DE and these patients composed the study population. The study patients were divided into 2 groups according to the occurrence of functional recovery defined as an increase in LV ejection fraction to a level of ≥50{\%} and net increase in ejection fraction of 20{\%} or more: group 1 (n = 14) with functional recovery and group 2 (n = 30) without functional recovery. Results In patients who showed functional recovery, left atrial volume index (LAVI [26 ± 8 mL/m2 vs 45 ± 18 mL/m2]) and LV end-diastolic dimension (62 ± 6 mm vs 67 ± 7 mm) were significantly smaller when compared with those without functional recovery (P < .05 for all). In Cox multiple regression analysis, LAVI was the only significant parameter associated with LV functional recovery (hazard ratio 0.932, 95{\%} confidence interval 0.877–0.991, P = .024). LAVI < 38 mL/m2 had 100{\%} specificity in predicting the improvement of LV systolic dysfunction. Conclusion In DCM patients who had no DE in CMR, LAVI predicts LV functional recovery with high specificity.",
author = "Jeonggeun Moon and ChiYoung Shim and Youngjin Kim and Sungha Park and seokmin kang and Namsik Chung and Ha, {Jong Won}",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.cardfail.2015.12.011",
language = "English",
volume = "22",
pages = "265--271",
journal = "Journal of Cardiac Failure",
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publisher = "Churchill Livingstone",
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TY - JOUR

T1 - Left Atrial Volume as a Predictor of Left Ventricular Functional Recovery in Patients With Dilated Cardiomyopathy and Absence of Delayed Enhancement in Cardiac Magnetic Resonance

AU - Moon, Jeonggeun

AU - Shim, ChiYoung

AU - Kim, Youngjin

AU - Park, Sungha

AU - kang, seokmin

AU - Chung, Namsik

AU - Ha, Jong Won

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background Improvement of left ventricular (LV) systolic dysfunction can occur in patients with dilated cardiomyopathy (DCM), and it is more frequently observed if patients have no delayed enhancement (DE) in cardiac magnetic resonance imaging (CMR). However, even in the absence of DE, not all patients have functional recovery. We retrospectively investigated the predictors of LV functional recovery in patients with DCM who had no DE in CMR. Methods A total of 136 patients with DCM underwent CMR. Among them, 44 (29 male, age 55 ± 14 years) showed no DE and these patients composed the study population. The study patients were divided into 2 groups according to the occurrence of functional recovery defined as an increase in LV ejection fraction to a level of ≥50% and net increase in ejection fraction of 20% or more: group 1 (n = 14) with functional recovery and group 2 (n = 30) without functional recovery. Results In patients who showed functional recovery, left atrial volume index (LAVI [26 ± 8 mL/m2 vs 45 ± 18 mL/m2]) and LV end-diastolic dimension (62 ± 6 mm vs 67 ± 7 mm) were significantly smaller when compared with those without functional recovery (P < .05 for all). In Cox multiple regression analysis, LAVI was the only significant parameter associated with LV functional recovery (hazard ratio 0.932, 95% confidence interval 0.877–0.991, P = .024). LAVI < 38 mL/m2 had 100% specificity in predicting the improvement of LV systolic dysfunction. Conclusion In DCM patients who had no DE in CMR, LAVI predicts LV functional recovery with high specificity.

AB - Background Improvement of left ventricular (LV) systolic dysfunction can occur in patients with dilated cardiomyopathy (DCM), and it is more frequently observed if patients have no delayed enhancement (DE) in cardiac magnetic resonance imaging (CMR). However, even in the absence of DE, not all patients have functional recovery. We retrospectively investigated the predictors of LV functional recovery in patients with DCM who had no DE in CMR. Methods A total of 136 patients with DCM underwent CMR. Among them, 44 (29 male, age 55 ± 14 years) showed no DE and these patients composed the study population. The study patients were divided into 2 groups according to the occurrence of functional recovery defined as an increase in LV ejection fraction to a level of ≥50% and net increase in ejection fraction of 20% or more: group 1 (n = 14) with functional recovery and group 2 (n = 30) without functional recovery. Results In patients who showed functional recovery, left atrial volume index (LAVI [26 ± 8 mL/m2 vs 45 ± 18 mL/m2]) and LV end-diastolic dimension (62 ± 6 mm vs 67 ± 7 mm) were significantly smaller when compared with those without functional recovery (P < .05 for all). In Cox multiple regression analysis, LAVI was the only significant parameter associated with LV functional recovery (hazard ratio 0.932, 95% confidence interval 0.877–0.991, P = .024). LAVI < 38 mL/m2 had 100% specificity in predicting the improvement of LV systolic dysfunction. Conclusion In DCM patients who had no DE in CMR, LAVI predicts LV functional recovery with high specificity.

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U2 - 10.1016/j.cardfail.2015.12.011

DO - 10.1016/j.cardfail.2015.12.011

M3 - Article

C2 - 26700660

AN - SCOPUS:84970021406

VL - 22

SP - 265

EP - 271

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

IS - 4

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