Leiomyosarcoma: investigation of prognostic factors for risk-stratification model

Hyun Ju Kim, Yong Jin Cho, Soo Hee Kim, Sun Young Rha, Joong Bae Ahn, Woo Ick Yang, Young Han Lee, Jin Suck Suh, Jae Kyung Roh, Kyung Sik Kim, Young Deuk Choi, Kyoo Ho Shin, Hyo Song Kim

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background: We performed this study to define distinctive clinical features of leiomyosarcoma by assessing prognostic factors. Methods: Between 1988 and 2011, 129 leiomyosarcoma patients who underwent surgical resection with curative intent were retrospectively reviewed. Results: Of the 129 leiomyosarcoma patients, the distribution of anatomic locations was: extremity (n = 25), pelvis (n = 40), thoracic cavity (n = 11), intra-abdomen (n = 19), retroperitoneum (n = 23), and head/neck (n = 11). We classified the anatomic locations into two categories as abdominal (intra-abdomen and retroperitoneum, n = 42) and extra-abdominal (extremity, pelvis, thoracic cavity, and head/neck, n = 87). Prognosis was worse for the abdominal group than for the extra-abdominal group (median DFS 2.9 9.0 years, P = 0.04). Similarly, overall survival (OS) was also significantly worse for abdominal group (P = 0.027). Independent prognostic factors for survival were primary site (P = 0.041, hazard ratio (HR) 1.7; 95 % CI 1.2–2.8), tumor size (P = 0.038, HR 1.9;  95 % CI  1.13–3.38), margin status (P = 0.019, HR 2.1; 95 % CI 1.13–3.88), and histology grade (P = 0.01, HR 3.59; 95 % CI 1.64–7.87). We identified four different risk groups with different survival outcome: group 1 (n = 8), no adverse factors; groups 2 (n = 37) and 3 (n = 61) with one and two adverse factors, and group 4 (n = 23) with 3 or 4 adverse factors. Conclusion: Primary site, tumor size, resection margin, and histology subtype were independently associated with survival outcome. A prognostic model for leiomyosarcoma patients revealed four distinct groups of patients with good prognostic discrimination.

Original languageEnglish
Pages (from-to)1226-1232
Number of pages7
JournalInternational Journal of Clinical Oncology
Issue number6
Publication statusPublished - 2015 Dec 1

Bibliographical note

Publisher Copyright:
© 2015, Japan Society of Clinical Oncology.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hematology
  • Oncology


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