Less fibrotic burden differently affects the long-term outcomes of hepatocellular carcinoma after curative resection

Hye Won Lee, Gi Hong Choi, Do Young Kim, Young Nyun Park, Kyung Sik Kim, Jin Sub Choi, Sang Hoon Ahn, Kwang Hyub Han

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Background: The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. Objective: We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. Methods: We retrospectively examined 649 consecutive patients with HCC who underwent curative resection from 1996 to 2012; 387 (59.6%) were cirrhotic and 262 (40.4%) were noncirrhotic. Results: The mean age was 54.7 years, and 511 (78.7%) of the study participants were men. The most common cause of HCC was hepatitis B virus (n = 419, 64.6%). Noncirrhotic tumors were larger and more advanced than cirrhotic tumors. However, the noncirrhotic group showed better disease-free survival (DFS) and overall survival (OS) after resection than the cirrhotic group (median 64.0 vs. 56.0 months for OS and 48.0 vs. 31.0 months for DFS, p < 0.05). The predictors for HCC recurrence were cirrhosis, tumor number, portal vein invasion, and major surgery. Conclusions: Noncirrhotic HCC showed better DFS and OS after resection than cirrhotic HCC, although noncirrhotic HCC presented more aggressively.

Original languageEnglish
Pages (from-to)224-232
Number of pages9
JournalOncology (Switzerland)
Issue number4
Publication statusPublished - 2017 Sep 1


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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