Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease

Dong Joo Yang, Kyung Suk Lee, Chang Mann Ko, Sang Hyun Moh, Jihyeok Song, Lucia C. Hur, Young Woo Cheon, Seung Ho Yang, Yun Hee Choi, Ki Woo Kim

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5 Citations (Scopus)

Abstract

The skin responds to environmental stressors by coordinated actions of neuropeptides and their receptors. An endogenous peptide for δ-opioid receptor (DOPr), Leu-enkephalin (L-ENK), is expressed in the skin and its expression is altered in pathological conditions. Although the importance of DOPr is rapidly gaining recognition, the molecular mechanisms underlying its effects on wound healing are largely undefined. We show here that L-ENK induced activation of Erk, P90RSK, and Elk-1 and promoted the disruption of hemidesmosomes and the expression of matrix metalloprotease (MMP)-2 and MMP-9, important processes for wound healing. Treatment with Erk inhibitor blocked activation of P90RSK and Elk-1 and significantly blunted wound repair. Therefore, our results suggest that activation of Erk and its downstream effectors, P90RSK and Elk-1, are critical for DOPr-mediated skin homeostasis.

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalPeptides
Volume76
DOIs
Publication statusPublished - 2016 Feb

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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    Yang, D. J., Lee, K. S., Ko, C. M., Moh, S. H., Song, J., Hur, L. C., Cheon, Y. W., Yang, S. H., Choi, Y. H., & Kim, K. W. (2016). Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease. Peptides, 76, 57-64. https://doi.org/10.1016/j.peptides.2015.12.010