Level of vascular endothelial growth factor in aqueous humor and surgical results of Ahmed glaucoma valve implantation in patients with Neovascular glaucoma

Yong Guk Kim, Samin Hong, Christopher Seungkyu Lee, Sung Yong Kang, Gong Je Seong, Kyoung Tak Ma, chanyun kim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Purpose: To determine the associations between the levels of growth factors in aqueous humor and the surgical outcomes of Ahmed glaucoma valve implantation in patients with neovascular glaucoma (NVG). Methods: From 19 NVG eyes of 19 patients, a sample of aqueous humor was taken just before Ahmed glaucoma valve implantation. Levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, and TGF-β2 in aqueous humor aspirates were measured using a sandwich enzyme-linked immunosorbent assay method. When the postoperative intraocular pressures were ≥21mm Hg with or without antiglaucoma medications at 2 successive visits or when any other surgical interventions were needed to lower intraocular pressure, that surgery was considered a failure. After patients were classified into success versus failure groups, the levels of the growth factors between the 2 groups was compared. The cumulative probability of success according to Kaplan-Meier analysis was also determined. Results: Mean postoperative follow-up period was 40.9±19.6 months and cumulative probability of success was 43% at 57 months after surgery. Mean VEGF level in the failure group was higher than that of the success group (P=0.014). However, there was no statistical difference in the levels of TGF-β1, TGF-β2, and protein between 2 study groups (all P>0.05). Conclusions: The level of VEGF in aqueous humor was significantly higher in the failure group after the Ahmed glaucoma implantation compared with the success group. Our results imply that VEGF may play a role in determining surgical success after Ahmed valve implantation in patients with NVG.

Original languageEnglish
Pages (from-to)443-447
Number of pages5
JournalJournal of Glaucoma
Volume18
Issue number6
DOIs
Publication statusPublished - 2009 Aug 1

Fingerprint

Neovascular Glaucoma
Aqueous Humor
Transforming Growth Factors
Glaucoma
Vascular Endothelial Growth Factor A
Intraocular Pressure
Intercellular Signaling Peptides and Proteins
Kaplan-Meier Estimate
Enzyme-Linked Immunosorbent Assay
Proteins

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Kim, Yong Guk ; Hong, Samin ; Lee, Christopher Seungkyu ; Kang, Sung Yong ; Seong, Gong Je ; Ma, Kyoung Tak ; kim, chanyun. / Level of vascular endothelial growth factor in aqueous humor and surgical results of Ahmed glaucoma valve implantation in patients with Neovascular glaucoma. In: Journal of Glaucoma. 2009 ; Vol. 18, No. 6. pp. 443-447.
@article{e416009087ee46be8c51159eecb5be08,
title = "Level of vascular endothelial growth factor in aqueous humor and surgical results of Ahmed glaucoma valve implantation in patients with Neovascular glaucoma",
abstract = "Purpose: To determine the associations between the levels of growth factors in aqueous humor and the surgical outcomes of Ahmed glaucoma valve implantation in patients with neovascular glaucoma (NVG). Methods: From 19 NVG eyes of 19 patients, a sample of aqueous humor was taken just before Ahmed glaucoma valve implantation. Levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, and TGF-β2 in aqueous humor aspirates were measured using a sandwich enzyme-linked immunosorbent assay method. When the postoperative intraocular pressures were ≥21mm Hg with or without antiglaucoma medications at 2 successive visits or when any other surgical interventions were needed to lower intraocular pressure, that surgery was considered a failure. After patients were classified into success versus failure groups, the levels of the growth factors between the 2 groups was compared. The cumulative probability of success according to Kaplan-Meier analysis was also determined. Results: Mean postoperative follow-up period was 40.9±19.6 months and cumulative probability of success was 43{\%} at 57 months after surgery. Mean VEGF level in the failure group was higher than that of the success group (P=0.014). However, there was no statistical difference in the levels of TGF-β1, TGF-β2, and protein between 2 study groups (all P>0.05). Conclusions: The level of VEGF in aqueous humor was significantly higher in the failure group after the Ahmed glaucoma implantation compared with the success group. Our results imply that VEGF may play a role in determining surgical success after Ahmed valve implantation in patients with NVG.",
author = "Kim, {Yong Guk} and Samin Hong and Lee, {Christopher Seungkyu} and Kang, {Sung Yong} and Seong, {Gong Je} and Ma, {Kyoung Tak} and chanyun kim",
year = "2009",
month = "8",
day = "1",
doi = "10.1097/IJG.0b013e3181895e5c",
language = "English",
volume = "18",
pages = "443--447",
journal = "Journal of Glaucoma",
issn = "1057-0829",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

Level of vascular endothelial growth factor in aqueous humor and surgical results of Ahmed glaucoma valve implantation in patients with Neovascular glaucoma. / Kim, Yong Guk; Hong, Samin; Lee, Christopher Seungkyu; Kang, Sung Yong; Seong, Gong Je; Ma, Kyoung Tak; kim, chanyun.

In: Journal of Glaucoma, Vol. 18, No. 6, 01.08.2009, p. 443-447.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Level of vascular endothelial growth factor in aqueous humor and surgical results of Ahmed glaucoma valve implantation in patients with Neovascular glaucoma

AU - Kim, Yong Guk

AU - Hong, Samin

AU - Lee, Christopher Seungkyu

AU - Kang, Sung Yong

AU - Seong, Gong Je

AU - Ma, Kyoung Tak

AU - kim, chanyun

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Purpose: To determine the associations between the levels of growth factors in aqueous humor and the surgical outcomes of Ahmed glaucoma valve implantation in patients with neovascular glaucoma (NVG). Methods: From 19 NVG eyes of 19 patients, a sample of aqueous humor was taken just before Ahmed glaucoma valve implantation. Levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, and TGF-β2 in aqueous humor aspirates were measured using a sandwich enzyme-linked immunosorbent assay method. When the postoperative intraocular pressures were ≥21mm Hg with or without antiglaucoma medications at 2 successive visits or when any other surgical interventions were needed to lower intraocular pressure, that surgery was considered a failure. After patients were classified into success versus failure groups, the levels of the growth factors between the 2 groups was compared. The cumulative probability of success according to Kaplan-Meier analysis was also determined. Results: Mean postoperative follow-up period was 40.9±19.6 months and cumulative probability of success was 43% at 57 months after surgery. Mean VEGF level in the failure group was higher than that of the success group (P=0.014). However, there was no statistical difference in the levels of TGF-β1, TGF-β2, and protein between 2 study groups (all P>0.05). Conclusions: The level of VEGF in aqueous humor was significantly higher in the failure group after the Ahmed glaucoma implantation compared with the success group. Our results imply that VEGF may play a role in determining surgical success after Ahmed valve implantation in patients with NVG.

AB - Purpose: To determine the associations between the levels of growth factors in aqueous humor and the surgical outcomes of Ahmed glaucoma valve implantation in patients with neovascular glaucoma (NVG). Methods: From 19 NVG eyes of 19 patients, a sample of aqueous humor was taken just before Ahmed glaucoma valve implantation. Levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, and TGF-β2 in aqueous humor aspirates were measured using a sandwich enzyme-linked immunosorbent assay method. When the postoperative intraocular pressures were ≥21mm Hg with or without antiglaucoma medications at 2 successive visits or when any other surgical interventions were needed to lower intraocular pressure, that surgery was considered a failure. After patients were classified into success versus failure groups, the levels of the growth factors between the 2 groups was compared. The cumulative probability of success according to Kaplan-Meier analysis was also determined. Results: Mean postoperative follow-up period was 40.9±19.6 months and cumulative probability of success was 43% at 57 months after surgery. Mean VEGF level in the failure group was higher than that of the success group (P=0.014). However, there was no statistical difference in the levels of TGF-β1, TGF-β2, and protein between 2 study groups (all P>0.05). Conclusions: The level of VEGF in aqueous humor was significantly higher in the failure group after the Ahmed glaucoma implantation compared with the success group. Our results imply that VEGF may play a role in determining surgical success after Ahmed valve implantation in patients with NVG.

UR - http://www.scopus.com/inward/record.url?scp=70249151447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70249151447&partnerID=8YFLogxK

U2 - 10.1097/IJG.0b013e3181895e5c

DO - 10.1097/IJG.0b013e3181895e5c

M3 - Article

VL - 18

SP - 443

EP - 447

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

IS - 6

ER -